scholarly journals A Dual pH-Responsive DOX-Encapsulated Liposome Combined with Glucose Administration Enhanced Therapeutic Efficacy of Chemotherapy for Cancer

2021 ◽  
Vol Volume 16 ◽  
pp. 3185-3199
Author(s):  
Luoping Zhai ◽  
Chuangwei Luo ◽  
Hannan Gao ◽  
Shuaifan Du ◽  
Jiyun Shi ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Ph Responsive ◽  
Glucose Administration

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

Albumin enhances PTX delivery ability of dextran NPs and therapeutic efficacy of PTX for colorectal cancer

2019 ◽  
Vol 7 (22) ◽  
pp. 3537-3545 ◽  
Author(s):  
Xinyu Zhang ◽  
Ruhe Zhang ◽  
Jun Huang ◽  
Moucheng Luo ◽  
Xuewen Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Ph Responsive

The nanoassemblies of Dex6k–BSA–PTX and the pH-responsive drug release for anti-tumor applications in vivo.

pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects

2021 ◽  
Vol 332 ◽  
pp. 529-538
Author(s):  
Lindomar J.C. Albuquerque ◽  
Vladimir Sincari ◽  
Alessandro Jäger ◽  
Jan Kucka ◽  
Jana Humajova ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Ph Responsive

Combined pH-responsive chemotherapy and glutathione-triggered photosensitization to overcome drug-resistant hepatocellular carcinoma — a SPP/JPP Young Investigator Award paper

2020 ◽  
Vol 24 (11n12) ◽  
pp. 1387-1401
Author(s):  
Di Gao ◽  
Pui-Chi Lo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Efficacy ◽  
Hepg2 Cells ◽  
Polymeric Micelles ◽  
Red Light ◽  
Spherical Shape ◽  
Therapeutic Modality ◽  
Ph Responsive ◽  
Therapeutic Modalities ◽  
Apoptosis And Necrosis

Doxorubicin (DOX) resistance, which results in a reduced accumulation of DOX in the nucleus and hence decreased DNA damage, is a major challenge for chemotherapy against hepatocellular carcinoma. In this paper, we combined chemotherapy with photodynamic therapy (PDT) to combat DOX-resistant human hepatocellular carcinoma cells. We have prepared the polymeric micelles conjugating with DOX and zinc(II) phthalocyanine (ZnPc) through a pH-responsive hydrazone linker and a glutathione (GSH)-responsive disulfide linker, respectively. The polymeric micelles (DOX-ZnPc-micelles) exhibited a spherical shape with a size of about 98 nm diameter and showed excellent stability in aqueous solution. Due to the self-quenching of the ZnPc inside the micelles, DOX-ZnPc-micelles did not emit fluorescence upon red light irradiation. Drug release experiments verified that DOX and ZnPc could be released under acidic conditions and reducing environments, respectively. A higher concentration of DOX was internalized into DOX-resistant R-HepG2 cells through the delivery of polymeric micelles when compared with the free DOX, hence DOX-ZnPc-micelles exhibited a significant enhancement in anticancer activity. The IC[Formula: see text] value of DOX against R-HepG2 cells was found to be 21 [Formula: see text]M when combined with PDT and it was 5-fold less than that of a single treatment of DOX (102 [Formula: see text]M). The DOX-ZnPc-micelles could induce cell apoptosis and necrosis on R-HepG2 cells by combined therapeutic modalities, while these micelles induced only apoptosis on HepG2 cells. We have demonstrated that utilization of polymeric micelles can significantly enhance the cellular uptake and cytotoxicity of DOX against R-HepG2 cells when compared with free DOX. Moreover, PDT can act as an adjuvant therapeutic modality and combine with chemotherapy to further improve therapeutic efficacy. Overall speaking, DOX-ZnPc-micelles can overcome DOX resistance and induce a synergistic therapeutic effect against DOX-resistant R-HepG2 cells, hence improving the therapeutic efficacy when compared with monotherapy.

Photographic evaluation of therapeutic efficacy

1968 ◽  
Vol 97 (3) ◽  
pp. 258-261
Author(s):  
H. M. Robinson
Keyword(s):  
Therapeutic Efficacy

Therapeutic efficacy of some extracts of hot pepper fruits (Capsicum annuum) and Sumac seeds (Rhus coriaria) on the growth of some isolated dermatophytes species

2018 ◽  
Vol 1 (3) ◽  
pp. 52-62
Author(s):  
Sara Omran ◽  
Abdulghani Alsamarai ◽  
Firas Razzzaq
Keyword(s):  
Antifungal Activity ◽  
Fungal Infection ◽  
Aqueous Extract ◽  
Plant Extracts ◽  
Therapeutic Efficacy ◽  
Diffusion Method ◽  
Quantitative Detection ◽  
Hot Pepper ◽  
Alcoholic Extract ◽  
Dermatology Clinic

Background: Fungal infections are one of the common skin diseases with difficulty in their treatment approach. The present efficient drugs for fungal infection are limited. Aim: To determine the therapeutic efficacy of plant extracts as alternative antifungal agents. Materials and methods: 100 clinical samples [68 from female and 32 from male] were collected during the period from March to July 2017 from subjects attending Dermatology Clinic in Salah Uldean General Hospital. Fungal infection was diagnosed with using KOH wet preparation. Fungal species identified by using conventional approach. The active ingredients existing in the plant extracts were detected and analyzed through qualitative and quantitative detection technique of chemical compounds using a high performance liquid chromatographic device (HPLC). Agar diffusion method was used to determine antifungal activity of plant extracts. Results: Direct microscopic examination showed that there were (75%) positive samples, while culture shows (67%) positive samples. The isolated dermatophytes belong to Epidermophyoton, Microsporum, and Trichophyton genus. The predominant dermatophytes were T. rubrum (25%) species. The highest frequency of infection was in the age group of 11-20 years. The sensitivity of the tested fungi to the aqueous and alcoholic plant extracts varies. Alcoholic extract of the hot pepper plant was more effective as antifungal than the aqueous extract of the same plant. However, aqueous hot pepper extracts was more effective against T. mentagrophyte than that of alcoholic extract. Additionally, alcoholic Sumac extract shows higher efficacy that aqueous extract. Conclusion: Hot pepper and Sumac extracts show antifungal activity against Microsporum canis, Trichophyton rubrum and T. mentagrophyte.

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