scholarly journals Investigating Halloysite Nanotubes as a Potential Platform for Oral Modified Delivery of Different BCS Class Drugs: Characterization, Optimization, and Evaluation of Drug Release Kinetics

2021 ◽  
Vol Volume 16 ◽  
pp. 1725-1741
Author(s):  
Tazeen Husain ◽  
Muhammad Harris Shoaib ◽  
Farrukh Rafiq Ahmed ◽  
Rabia Ismail Yousuf ◽  
Sadaf Farooqi ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Halloysite Nanotubes ◽  
Drug Release Kinetics

scholarly journals Improvement of Drug Release and Compatibility between Hydrophilic Drugs and Hydrophobic Nanofibrous Composites

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5344
Author(s):  
Hazim J. Haroosh ◽  
Yu Dong ◽  
Shaimaa Jasim ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Halloysite Nanotubes ◽  
Polymer Processing ◽  
Hydrophilic Drugs ◽  
Drug Release Kinetics ◽  
Flexible Polymer ◽  
The Impact

Electrospinning is a flexible polymer processing method to produce nanofibres, which can be applied in the biomedical field. The current study aims to develop new electrospun hybrid nanocomposite systems to benefit the sustained release of hydrophilic drugs with hydrophobic polymers. In particular, electrospun hybrid materials consisting of polylactic acid (PLA):poly(ε-caprolactone) (PCL) blends, as well as PLA:PCL/halloysite nanotubes-3-aminopropyltriethoxysilane (HNT-ASP) nanocomposites were developed in order to achieve sustained release of hydrophilic drug tetracycline hydrochloride (TCH) using hydrophobic PLA:PCL nanocomposite membranes as a drug carrier. The impact of interaction between two commonly used drugs, namely TCH and indomethacin (IMC) and PLA:PCL blends on the drug release was examined. The drug release kinetics by fitting the experimental release data with five mathematical models for drug delivery were clearly demonstrated. The average nanofiber diameters were found to be significantly reduced when increasing the TCH concentration due to increasing solution electrical conductivity in contrast to the presence of IMC. The addition of both TCH and IMC drugs to PLA:PCL blends reduced the crystallinity level, glass transition temperature (Tg) and melting temperature (Tm) of PCL within the blends. The decrease in drug release and the impairment elimination for the interaction between polymer blends and drugs was accomplished by mobilising TCH into HNT-ASP for their embedding effect into PLA:PCL nanofibres. The typical characteristic was clearly identified with excellent agreement between our experimental data obtained and Ritger–Peppas model and Zeng model in drug release kinetics. The biodegradation behaviour of nanofibre membranes indicated the effective incorporation of TCH onto HNT-ASP.

Drug release kinetics from biodegradable UV-transparent hollow calcium-phosphate glass fibers

2017 ◽  
Vol 191 ◽  
pp. 116-118 ◽  
Author(s):  
Edoardo Ceci-Ginistrelli ◽  
Carlotta Pontremoli ◽  
Diego Pugliese ◽  
Nadia Barbero ◽  
Nadia G. Boetti ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Phosphate Glass ◽  
Release Kinetics ◽  
Glass Fibers ◽  
Drug Release Kinetics

scholarly journals Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

2021 ◽  
Vol 20 (4) ◽  
pp. 565-576
Author(s):  
Nour Al Sawaftah ◽  
Vinod Paul ◽  
Nahid Awad ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cancer Drug ◽  
Drug Release Kinetics ◽  
Anti Cancer

scholarly journals Tuneable spheroidal hydrogel particles for cell and drug encapsulation

Soft Matter ◽  
2018 ◽  
Vol 14 (27) ◽  
pp. 5622-5627 ◽  
Author(s):  
Isabel M. Bjørge ◽  
Ana M. S. Costa ◽  
A. Sofia Silva ◽  
João P. O. Vidal ◽  
J. Miguel Nóbrega ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cell Encapsulation ◽  
Drug Encapsulation ◽  
Drug Release Kinetics ◽  
Hydrogel Particles ◽  
The Impact

Straight-forward production of spheroidal particles allows the assessment of the impact of geometry on cell encapsulation viability and drug release kinetics.

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