scholarly journals Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species

2012 ◽  
pp. 845 ◽  
Author(s):  
Maqusood Ahamed ◽  
Javed Akhtar ◽  
Kumar ◽  
Majeed Khan ◽  
Ahmad ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zinc Oxide ◽  
Cancer Cells ◽  
Zinc Oxide Nanoparticles ◽  
Human Cancer ◽  
Reactive Oxygen ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Human Cancer Cells

Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

2018 ◽  
Vol 6 (30) ◽  
pp. 4852-4871 ◽  
Author(s):  
Padmanaban Sivakumar ◽  
Minjong Lee ◽  
Yoon-Seok Kim ◽  
Min Suk Shim
Keyword(s):  
Reactive Oxygen Species ◽  
Zinc Oxide ◽  
Cancer Cells ◽  
Zinc Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Light Irradiation ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Anticancer Activities ◽  
Zno Nps

Zinc oxide nanoparticles (ZnO NPs) generate reactive oxygen species and thus induce phototoxicity against bacteria and cancer cells due to their photocatalytic effects under light irradiation. This review introduces and discusses recent research regarding the utilization of ZnO NPs for light-triggered antibacterial and anticancer activities.

scholarly journals The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1161 ◽  
Author(s):  
Magdalena Cal ◽  
Irwin Matyjaszczyk ◽  
Ireneusz Litwin ◽  
Daria Augustyniak ◽  
Rafał Ogórek ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Cancer Cells ◽  
Human Cancer ◽  
Reactive Oxygen ◽  
Atp Depletion ◽  
Mitochondrial Enzymes ◽  
Oxygen Species ◽  
Human Cancer Cells ◽  
The Impact

3-bromopyruvate (3-BP) is a small molecule with anticancer and antimicrobial activities. 3-BP is taken up selectively by cancer cells’ mono-carboxylate transporters (MCTs), which are highly overexpressed by many cancers. When 3-BP enters cancer cells it inactivates several glycolytic and mitochondrial enzymes, leading to ATP depletion and the generation of reactive oxygen species. While mechanisms of 3-BP uptake and its influence on cell metabolism are well understood, the impact of 3-BP at certain concentrations on DNA integrity has never been investigated in detail. Here we have collected several lines of evidence suggesting that 3-BP induces DNA damage probably as a result of ROS generation, in both yeast and human cancer cells, when its concentration is sufficiently low and most cells are still viable. We also demonstrate that in yeast 3-BP treatment leads to generation of DNA double-strand breaks only in S-phase of the cell cycle, possibly as a result of oxidative DNA damage. This leads to DNA damage, checkpoint activation and focal accumulation of the DNA response proteins. Interestingly, in human cancer cells exposure to 3-BP also induces DNA breaks that trigger H2A.X phosphorylation. Our current data shed new light on the mechanisms by which a sufficiently low concentration of 3-BP can induce cytotoxicity at the DNA level, a finding that might be important for the future design of anticancer therapies.

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