scholarly journals Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol‐Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities

2021 ◽  
Vol Volume 16 ◽  
pp. 2461-2475
Author(s):  
Jie Hu ◽  
Juan Luo ◽  
Meiling Zhang ◽  
Jiashu Wu ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Carbon Dots ◽  
Antioxidant Activities ◽  
Protective Effects ◽  
Anti Inflammatory

scholarly journals The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3064 ◽  
Author(s):  
Yuzhu He ◽  
Byung-gook Kim ◽  
Hye-Eun Kim ◽  
Qiaochu Sun ◽  
Shuhan Shi ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Protective Role ◽  
Related Factor ◽  
Nuclear Factor ◽  
Hacat Cells ◽  
Protective Effects ◽  
Hydroxycinnamic Acid Amides ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Human epidermis mainly comprises keratinocytes whose inflammation causes skin problems. This study investigated the protective effects of FS on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. The mechanism was investigated by analyzing cell viability, PGE2 levels, cell apoptosis, nuclear factor erythroid 2-related factor 2 (Nrf2) translocation, and TLR4/NF-κB pathway. The anti-inflammatory effects of FS were assessed by inhibiting the inflammation via down-regulating the TLR4/NF-κB pathway. Additionally, FS promoted Nrf2 translocation to the nucleus, indicating that FS showed anti-oxidative activities. Furthermore, the antioxidative and anti-inflammatory effects of FS were found to benefit each other, but were independent. Thus, FS can be used as a component to manage epidermal inflammation due to its anti-inflammatory and anti-oxidative properties.

scholarly journals Heme Oxygenase-1, a Key Enzyme for the Cytoprotective Actions of Halophenols by Upregulating Nrf2 Expression via Activating Erk1/2 and PI3K/Akt in EA.hy926 Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Xiu E. Feng ◽  
Tai Gang Liang ◽  
Jie Gao ◽  
De Peng Kong ◽  
Rui Ge ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Antioxidant Activities ◽  
Heme Oxygenase 1 ◽  
Protective Effects ◽  
Key Enzyme ◽  
Ea.Hy926 Cells ◽  
Anti Inflammatory ◽  
Mechanistic Basis

Increasing evidence has demonstrated that heme oxygenase-1 (HO-1) is a key enzyme triggered by cellular stress, exhibiting cytoprotective, antioxidant, and anti-inflammatory abilities. Previously, we prepared a series of novel active halophenols possessing strong antioxidant activities in vitro and in vivo. In the present study, we demonstrated that these halophenols exhibited significant protective effects against H2O2-induced injury in EA.hy926 cells by inhibition of apoptosis and ROS and TNF-αproduction, as well as induction of the upregulation of HO-1, the magnitude of which correlated with their cytoprotective actions. Further experiments which aimed to determine the mechanistic basis of these actions indicated that the halophenols induced the activation of Nrf2, Erk1/2, and PI3K/Akt without obvious effects on the phosphorylation of p38, JNK, or the expression of PKC-δ. This was validated with the use of PD98059 and Wortmannin, specific inhibitors of Erk1/2 and PI3K, respectively. Overall, our study is the first to demonstrate that the cytoprotective actions of halophenols involve their antiapoptotic, antioxidant, and anti-inflammatory abilities, which are mediated by the upregulation of Nrf2-dependent HO-1 expression and reductions in ROS and TNF-αgeneration via the activation of Erk1/2 and PI3K/Akt in EA.hy926 cells. HO-1 may thus be an important potential target for further research into the cytoprotective actions of halophenols.

scholarly journals Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Jiawei Liu ◽  
Huijiao Lin ◽  
Liwei Yuan ◽  
Dan Wang ◽  
Chunmei Wang ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Signaling Pathway ◽  
Interleukin 2 ◽  
Gastrointestinal Diseases ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Gastric Ulcers ◽  
Protective Effects ◽  
Gastric Tissue ◽  
Anti Inflammatory

Gastric ulcer is one of the most common gastrointestinal diseases. Anwulignan (AN) is a major active component of Schisandra sphenanthera Rehd. This study was designed to evaluate the protective effect of AN against the acute gastric ulcer induced by HCl/ethanol in mice. The mice were given HCl/ethanol by gavage to establish an acute gastric ulcer model. Then, the serum and gastric tissue samples were taken for biochemical analyses. The results showed that the pretreatment with AN could significantly reduce the gastric ulcer index (GUI) and increase the ulcer inhibition rate, indicating that AN can protect against gastric ulcers. AN showed its antioxidant roles by decreasing the content of reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) and increasing the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and anti-inflammatory roles by decreasing the content of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and myeloperoxidase (MPO) and increasing the content of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10), prostaglandin E2 (PGE2), and nitric oxide (NO) in both serum and gastric tissue. Furthermore, AN also activated the NRF2/ARE signaling pathway and inhibited the MAPK/NF-κB signaling pathway. AN improves the acute gastric ulcer induced by HCl/ethanol in mice, which may be mainly through its antioxidant capacity and anti-inflammatory effect.

scholarly journals Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 451 ◽  
Author(s):  
Azahara Rodríguez-Luna ◽  
Javier Ávila-Román ◽  
Helena Oliveira ◽  
Virginia Motilva ◽  
Elena Talero
Keyword(s):  
Natural Products ◽  
Rosmarinic Acid ◽  
Antioxidant Activities ◽  
Skin Inflammation ◽  
Protective Effects ◽  
Hacat Keratinocytes ◽  
Antioxidant Genes ◽  
Genes Expression ◽  
Anti Inflammatory ◽  
Induced Apoptosis

Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin pathologies or cancer because it encourages oxidative condition and skin inflammation. In this sense, strategies for its prevention are currently being evaluated. Natural products such as carotenoids or polyphenols, which are abundant in the marine environment, have been used in the prevention of oxidative stress due to their demonstrated antioxidant activities. Nevertheless, the anti-inflammatory activity and its implication in photo-prevention have not been extensively studied. Thus, we aimed to evaluate the combination of fucoxanthin (FX) and rosmarinic acid (RA) on cell viability, apoptosis induction, inflammasome regulation, and anti-oxidative response activation in UVB-irradiated HaCaT keratinocytes. We demonstrated for the first time that the combination of FX and RA (5 µM RA plus 5 μM FX, designated as M2) improved antioxidant and anti-inflammatory profiles in comparison to compounds assayed individually, by reducing UVB-induced apoptosis and the consequent ROS production. Furthermore, the M2 combination modulated the inflammatory response through down-regulation of inflammasome components such as NLRP3, ASC, and Caspase-1, and the interleukin (IL)-1β production. In addition, Nrf2 and HO-1 antioxidant genes expression increased in UVB-exposed HaCaT cells pre-treated with M2. These results suggest that this combination of natural products exerts photo-protective effects by down-regulating NRLP3-inflammasome and increasing Nrf2 signalling pathway.

Schisantherin-A Alleviates Lipopolysaccharide-Induced Inflammation and Apoptosis in WI-38 Cells

2021 ◽  
Vol 19 (4) ◽  
pp. 421-426
Author(s):  
Shan Liu ◽  
Banghao Lu
Keyword(s):  
Protein Kinase ◽  
Antioxidant Activities ◽  
Kidney Injury ◽  
Mitogen Activated Protein Kinase ◽  
Protective Effects ◽  
Extracellular Signal ◽  
Acute Pneumonia ◽  
Mitogen Activated Protein ◽  
Anti Inflammatory ◽  
Schisantherin A

Schisantherin A, a dibenzocyclooctadiene lignan, isolated from the fruit of Schisandra sphenanthera has been widely used to exert anti-inflammatory or antioxidant activities in sepsis associated acute kidney injury and lipopolysaccharide associated acute respiratory distress syndrome. However, the protective effects of Schisantherin A against acute pneumonia in lipopolysaccharide-induced WI-38 remain to be explored. To this end, WI-38 cells were treated with lipopolysaccharide to establish an acute pneumonia model and evaluate the effect of Schisantherin A. The data show an increase in apoptosis and decrease in cell viability by lipopolysaccharide treatment that was reversed by Schisantherin A. Also, Schisantherin A dose dependently attenuated lipopolysaccharide-induced increase in proinflammatory cytokines. Lastly, expression of p65, p38 proteins, extracellular-signal-regulated kinase, and Jun N-terminal protein kinase phosphorylation were upregulated by lipopolysaccharide and decreased by Schisantherin A. In conclusion, Schisantherin A demonstrates anti-inflammatory and antiapoptotic roles in lipopolysaccharide induced WI-38 cells through inactivation of nuclear factor-kappa B/mitogen activated protein kinase pathway.

Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms

2016 ◽  
Vol 7 (1) ◽  
pp. 398-408 ◽  
Author(s):  
Paulrayer Antonisamy ◽  
Mariadhas Valan Arasu ◽  
Muniappan Dhanasekaran ◽  
Ki Choon Choi ◽  
Adithan Aravinthan ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protective Effects ◽  
Gastroprotective Activity ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

The gastroprotective activity of trigonelline against indomethacin-induced ulcer and the role of anti-oxidant, anti-inflammatory and anti-apoptotic mechanisms have been explored.

scholarly journals Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 176
Author(s):  
Mohamed Nabil ◽  
Mohamed A. El Raey ◽  
Walied Abdo ◽  
Mohamed A. O. Abdelfattah ◽  
Assem M. El-Shazly ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
In Vivo Studies ◽  
Gastric Ulcers ◽  
Potential Candidate ◽  
Protective Effects ◽  
Ulcer Model ◽  
Anti Inflammatory

We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work, we explored the gastroprotective effects of the leaf extract in an indomethacin-induced ulcer model and the mechanisms involved. The rats being pretreated with the tested extract (100 and 200 mg kg−1) significantly prevented gastric lesions by 87.4% and 92.3%, respectively, and they had no structural derangements in the gastric mucosa. The extract significantly reduced the elevated levels of IKκB, NF-κB, TNF-α, IL-6, iNOS, and lipid peroxidation; increased the reduced level of glutathione peroxidase (GPx) activity; and reduced glutathione (GSH) in the indomethacin-induced ulcer model. The protective activities of the extract were similar in most aspects to those exerted by the known anti-ulcer drug famotidine. These activities might be attributed to the anti-inflammatory and antioxidant activities, and the reduction of iNOS levels. In conclusion, Albizia anthelmintica is a potential candidate for management of gastric ulcers with antioxidant properties.

Anti-Inflammatory and Barrier-Protective Effects of Berberine

2011 ◽  
Vol 49 (10) ◽  
Author(s):  
Lena John ◽  
Anja Fromm ◽  
Michael Fromm ◽  
Jörg-Dieter Schulzke ◽  
Maren Amasheh
Keyword(s):  
Protective Effects ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document