scholarly journals Cinnamaldehyde and Doxorubicin Co-Loaded Graphene Oxide Wrapped Mesoporous Silica Nanoparticles for Enhanced MCF-7 Cell Apoptosis

2020 ◽  
Vol Volume 15 ◽  
pp. 10285-10304
Author(s):  
Kai Dong ◽  
Zhuang-Zhuang Zhao ◽  
Jian Kang ◽  
Lei-Ruo Lin ◽  
Wen-Ting Chen ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Apoptosis ◽  
Mesoporous Silica Nanoparticles ◽  
Mcf 7

scholarly journals A flexible smart membrane consisting of GO composite fibres and upconversion MSNs for microRNA detection

2019 ◽  
Vol 55 (62) ◽  
pp. 9104-9107 ◽  
Author(s):  
Tongxu Gu ◽  
Zhaohui Ren ◽  
Xiang Li ◽  
Jie Huang ◽  
Gaorong Han
Keyword(s):  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Dna Probes ◽  
Single Stranded Dna ◽  
Microrna Detection ◽  
Flexible Polyurethane

We have developed a photoluminescent membrane for microRNA detection, consisting of mesoporous silica nanoparticles (CaF2:Yb/Ho@MSNs) attached, via single stranded DNA probes, to flexible polyurethane fibres coated with graphene oxide (GO).

Reduced graphene oxide gated mesoporous silica nanoparticles as a versatile chemo-photothermal therapy system through pH controllable release

2015 ◽  
Vol 3 (30) ◽  
pp. 6377-6384 ◽  
Author(s):  
Ting Ting Wang ◽  
Jing Lan ◽  
Yue Zhang ◽  
Zhu Lian Wu ◽  
Chun Mei Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Reduced Graphene Oxide ◽  
Photothermal Therapy ◽  
Mesoporous Silica Nanoparticles ◽  
Reduced Graphene ◽  
Controllable Release ◽  
Acidic Environments

A multifunctional drug delivery system involving coupling photothermal therapy and chemotherapy together was developed, which based on the combination of rGO and MSNs, wherein the cargo molecules could be released in acidic environments due to the cleavage of the CN bond of Schiff bases.

scholarly journals An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6304-6310 ◽  
Author(s):  
Yuxia Tang ◽  
Hao Hu ◽  
Molly Gu Zhang ◽  
Jibin Song ◽  
Liming Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

scholarly journals Understanding the driving forces of camptothecin interactions on the surface of nanocomposites based on graphene oxide decorated with silica nanoparticles

2020 ◽  
Vol 2 (3) ◽  
pp. 1290-1300 ◽  
Author(s):  
Leandro C. Fonseca ◽  
Marcelo de Sousa ◽  
Djalma L. S. Maia ◽  
Luis Visani de Luna ◽  
Oswaldo L. Alves
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Driving Forces ◽  
Mesoporous Silica Nanoparticles ◽  
Antitumor Drug ◽  
Release Studies

Novel nanocomposites based on graphene oxide decorated with mesoporous silica nanoparticles comprising adsorbed camptothecin antitumor drug and their drug release studies.

scholarly journals Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2749 ◽  
Author(s):  
Abeer Beagan ◽  
Shatha Lahmadi ◽  
Ahlam Alghamdi ◽  
Majed Halwani ◽  
Mohammed Almeataq ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Drug Concentrations ◽  
Cytotoxicity Studies ◽  
Hollow Mesoporous Silica ◽  
Mcf 7

This work presents the synthesis of pH-responsive poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes anchored on hollow mesoporous silica nanoparticles (HMSN-PDEAEMA) via a surface-initiated ARGET ATRP technique. The average size of HMSNs was ca. 340 nm, with a 90 nm mesoporous silica shell. The dry thickness of grafted PDEAEMA brushes was estimated to be ca 30 nm, as estimated by SEM and TEM. The halogen group on the surface of PDEAMA brushes was successfully derivatized with glucosamine, as confirmed by XPS. The effect of pH on the size of the hybrid nanoparticles was investigated by DLS. The size of fabricated nanoparticle decreased from ca. 950 nm in acidic media to ca. 500 nm in basic media due to the deprotonation of tertiary amine in the PDEAEMA. The PDEAEMA modified HMSNs nanocarrier was efficiently loaded with doxorubicin (DOX) with a loading capacity of ca. 64%. DOX was released in a relatively controlled pH-triggered manner from hybrid nanoparticles. The cytotoxicity studies demonstrated that DOX@HMSN-PDEAEMA-Glucosamine showed a strong ability to kill breast cancer cells (MCF-7 and MCF-7/ADR) at low drug concentrations, in comparison to free DOX.

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