scholarly journals RGD-conjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating αvβ3 expression

2012 ◽  
pp. 915 ◽  
Author(s):  
Shen Fu ◽  
Xu ◽  
Luo ◽  
Li ◽  
Zhou ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Gold Nanorods ◽  
Melanoma Cancer ◽  
Alpha V Beta 3

Single-chain antibody-decorated Au nanocages@liposomal layer nanoprobes for targeted SERS imaging and remote-controlled photothermal therapy of melanoma cancer cells

2021 ◽  
Vol 124 ◽  
pp. 112086
Author(s):  
Ghazal Farahavar ◽  
Samira Sadat Abolmaali ◽  
Foroogh Nejatollahi ◽  
Amin Safaie ◽  
Sanaz Javanmardi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Melanoma Cancer ◽  
Sers Imaging

B16 Melanoma Cancer Cells with Higher Metastatic Potential are More Deformable at a Whole-Cell Level

2021 ◽  
Author(s):  
Yoshihiro Ujihara ◽  
Daichi Ono ◽  
Koki Nishitsuji ◽  
Megumi Ito ◽  
Shukei Sugita ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Metastatic Potential ◽  
B16 Melanoma ◽  
Cell Level ◽  
Whole Cell ◽  
Melanoma Cancer

scholarly journals CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Carmela Martini ◽  
Mark DeNichilo ◽  
Danielle P. King ◽  
Michaelia P. Cockshell ◽  
Brenton Ebert ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cancer Cells ◽  
Vasculogenic Mimicry ◽  
Tumor Vasculature ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Cell Surface Glycoprotein ◽  
Melanoma Cancer ◽  
In Vitro Angiogenesis

Abstract Background The formation of blood vessels within solid tumors directly contributes to cancer growth and metastasis. Until recently, tumor vasculature was thought to occur exclusively via endothelial cell (EC) lined structures (i.e. angiogenesis), but a second source of tumor vasculature arises from the cancer cells themselves, a process known as vasculogenic mimicry (VM). While it is generally understood that the function of VM vessels is the same as that of EC-lined vessels (i.e. to supply oxygen and nutrients to the proliferating cancer cells), the molecular mechanisms underpinning VM are yet to be fully elucidated. Methods Human VM-competent melanoma cell lines were examined for their VM potential using the in vitro angiogenesis assays (Matrigel), together with inhibition studies using small interfering RNA and blocking monoclonal antibodies. Invasion assays and adhesion assays were used to examine cancer cell function. Results Herein we demonstrate that CD36, a cell surface glycoprotein known to promote angiogenesis by ECs, also supports VM formation by human melanoma cancer cells. In silico analysis of CD36 expression within the melanoma cohort of The Cancer Genome Atlas suggests that melanoma patients with high expression of CD36 have a poorer clinical outcome. Using in vitro ‘angiogenesis’ assays and CD36-knockdown approaches, we reveal that CD36 supports VM formation by human melanoma cells as well as adhesion to, and invasion through, a cancer derived extracellular matrix substrate. Interestingly, thrombospondin-1 (TSP-1), a ligand for CD36 on ECs that inhibits angiogenesis, has no effect on VM formation. Further investigation revealed a role for laminin, but not collagen or fibronectin, as ligands for CD36 expressing melanoma cells. Conclusions Taken together, this study suggests that CD36 is a novel regulator of VM by melanoma cancer cells that is facilitated, at least in part, via integrin-α3 and laminin. Unlike angiogenesis, VM is not perturbed by the presence of TSP-1, thus providing new information on differences between these two processes of tumor vascularization which may be exploited to combat cancer progression.

scholarly journals Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods

2021 ◽  
pp. 2102666
Author(s):  
Fulei Zhang ◽  
Yi Hou ◽  
Minhui Zhu ◽  
Bo Deng ◽  
Mengxin Zhao ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Gold Nanorods ◽  
Surface Molecule

scholarly journals Indirect Cold Atmospheric Pressure Plasma treatment on Melanoma and Fibroblast Cells

2020 ◽  
Vol 10 (2) ◽  
pp. 2117-2125
Keyword(s):  
Plasma Treatment ◽  
Cancer Cells ◽  
Culture Medium ◽  
Atmospheric Pressure Plasma ◽  
Control Group ◽  
Fibroblast Cells ◽  
Alizarin Red ◽  
Migration Assay ◽  
Melanoma Cancer

Cold atmosphere plasma has been shown as a promising technology for certain cancer treatments. In this paper, we report indirect plasma treatment using CAP discharged in cell culture medium and study the effect of identical plasma stimulated culture medium on melanoma cancer cells and fibroblast cells cultured in vitro. The results of MTT assay, migration assay, ROS detection, and alizarin red assay show that plasma-treated medium can have a strong negative effect on melanoma cancer cells compared with the control group. However, the plasma-treated medium has a less cytotoxic effect on fibroblast cells than that on melanoma cancer cells at the same treatment. This result is attributed to the production of reactive oxygen species in the plasma-treated medium to induce apoptosis and inhibit melanoma cell proliferation and further cell metastasis. According to the results, this study shows the potential of CAP plasma treatment for anti-cancer therapy.

scholarly journals Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13432-13442 ◽  
Author(s):  
Lun Qin ◽  
Peijian Yan ◽  
Congkun Xie ◽  
Jie Huang ◽  
Zhaohui Ren ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Therapeutic System

A localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers, offers the potential for a LED-induced mild photothermal effect which enhances gene silencing effect in cancer cells.

Sign in / Sign up

Export Citation Format

Share Document