scholarly journals p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides

2021 ◽  
Vol Volume 16 ◽  
pp. 283-296
Author(s):  
Yunhan Zhang ◽  
Meihui Xia ◽  
Zizhen Zhou ◽  
Xiaoqing Hu ◽  
Jiabin Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Human Serum ◽  
Cancer Cells ◽  
Iron Oxides ◽  
Ovarian Cancer Cells ◽  
Superparamagnetic Iron Oxides

Design of fluorophore-loaded human serum albumin nanoparticles for specific targeting of NIH:OVCAR3 ovarian cancer cells

2020 ◽  
Vol 31 (31) ◽  
pp. 315102 ◽  
Author(s):  
Raluca Borlan ◽  
Andra-Sorina Tatar ◽  
Olga Soritau ◽  
Dana Maniu ◽  
Gabriel Marc ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Specific Targeting ◽  
Albumin Nanoparticles

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects

Lupeol Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/ Mammalian Target of Rapamycin Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 206-210
Author(s):  
Feng Chen ◽  
Bei Zhang
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Protein Kinase ◽  
Cell Viability ◽  
Cancer Cells ◽  
Protein Kinase B ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Ovarian Cancer Cells ◽  
Phosphoinositide 3 Kinase

Lupeol exhibits multiple pharmacological activities including, anticancerous, anti-inflammatory, and antioxidant. The aim of this study was to explore the anticancerous activity of lupeol on ovarian cancer cells and examine its mechanism of action. To this end, increasing concentrations of lupeol on cell viability, cell cycle, and apoptosis in Caov-3 cells were evaluated. Lupeol inhibited cell viability, induced G1 phase arrest in cell cycle, increased cell apoptosis, and inhibited the ratio of phospho-Akt/protein kinase B and phospho-mammalian target of rapamycin/mammalian target of rapamycin. In conclusion, these data suggest that lupeol may play a therapeutic role in ovarian cancer.

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