scholarly journals Tumour-Targeted and Redox-Responsive Mesoporous Silica Nanoparticles for Controlled Release of Doxorubicin and an siRNA Against Metastatic Breast Cancer

2021 ◽  
Vol Volume 16 ◽  
pp. 1961-1976
Author(s):  
Jialang Zhuang ◽  
Siqi Chen ◽  
Ye Hu ◽  
Fan Yang ◽  
Qin Huo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Metastatic Breast ◽  
Redox Responsive

scholarly journals A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles

RSC Advances ◽  
2017 ◽  
Vol 7 (57) ◽  
pp. 35704-35710 ◽  
Author(s):  
Hongnan Qu ◽  
Liangrong Yang ◽  
Jiemiao Yu ◽  
Tingting Dong ◽  
Meng Rong ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Sustained Release ◽  
Silica Nanoparticles ◽  
Au Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release System ◽  
Redox Responsive ◽  
Controlled Release System

A redox responsive controlled and sustained release system based on the host–guest interaction between ferrocene and β-cyclodextrin was developed.

P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release

2015 ◽  
Vol 26 (10) ◽  
pp. 1203-1208 ◽  
Author(s):  
Yu-Jie Chang ◽  
Xi-Zhen Liu ◽  
Qing Zhao ◽  
Xiao-Hai Yang ◽  
Ke-Min Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo

Langmuir ◽  
2014 ◽  
Vol 30 (26) ◽  
pp. 7867-7877 ◽  
Author(s):  
Liangliang Dai ◽  
Jinghua Li ◽  
Beilu Zhang ◽  
Junjie Liu ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Redox Responsive

scholarly journals Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

2015 ◽  
Vol 25 (18) ◽  
pp. 2646-2659 ◽  
Author(s):  
Worapol Ngamcherdtrakul ◽  
Jingga Morry ◽  
Shenda Gu ◽  
David J. Castro ◽  
Shaun M. Goodyear ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Cationic Polymer ◽  
Her2 Breast Cancer

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

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