scholarly journals Facilitated and Controlled Strontium Ranelate Delivery Using GCS-HA Nanocarriers Embedded into PEGDA Coupled with Decortication Driven Spinal Regeneration

2021 ◽  
Vol Volume 16 ◽  
pp. 4209-4224
Author(s):  
Chih-Wei Chiang ◽  
Chih-Hwa Chen ◽  
Yankuba B Manga ◽  
Shao-Chan Huang ◽  
Kun-Mao Chao ◽  
...  
Keyword(s):  
Strontium Ranelate

scholarly journals Cumulative Effects Of Strontium Ranelate and Impact Exercise On Bone Mass In Ovariectomized Rats

2021 ◽  
Vol 22 (6) ◽  
pp. 3040
Author(s):  
Priscilla Aveline ◽  
Annabelle Cesaro ◽  
Marija Mazor ◽  
Thomas M. Best ◽  
Eric Lespessailles ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Fat Mass ◽  
Lipid Content ◽  
Strontium Ranelate ◽  
Bending Test ◽  
Ovariectomized Rats ◽  
Whole Body ◽  
Left Femur ◽  
Osteocyte Apoptosis ◽  
Ovx Rats

OBJECTIVE: To explore the effect of physical exercise (EXE), strontium ranelate (SR), or their combination on bone status in ovariectomized (OVX) rats. DESIGN: Sixty female Wistar rats were randomized to one of five groups: sham (Sh), OVX (O), OVX+EXE (OE), OVX+SR (OSR), and OVX+EXE+SR (OESR). Animals in EXE groups were subjected to 10 drops per day (45 cm in height); rats in SR groups received 625 mg/kg/day of SR, 5 days/week for 8 weeks. Bone mineral density (BMD) and bone mineral content (BMC, dual-energy X-ray absorptiometry (DXA)), mechanical strength of the left femur (three-point bending test), and femur microarchitecture of (micro-computed tomography imaging, microCT) analyses were performed to characterize biomechanical and trabecular/cortical structure. Bone remodeling, osteocyte apoptosis, and lipid content were evaluated by ELISA and immunofluorescence tests. RESULTS: In OVX rats, whole-body BMD, trabecular parameters, and osteocalcin (OCN) levels decreased, while weight, lean/fat mass, osteocyte apoptosis, and lipid content all increased. EXE after ovariectomy improved BMD and BMC, trabecular parameters, cross-sectional area (CSA), moment of inertia, and OCN levels while decreasing osteocyte apoptosis and lipid content. SR treatment increased BMD and BMC, trabecular parameters, CSA, stiffness, OCN, and alkaline phosphatase (ALP) levels. Furthermore, fat mass, N-telopeptide (NTX) level, osteocyte apoptosis, and lipid content significantly decreased. The combination of both EXE and SR improved bone parameters compared with EXE or SR alone. CONCLUSION: EXE and SR had positive and synergistic effects on bone formation and resorption.

scholarly journals Could Strontium Ranelate Have a Synergistic Role in the Treatment of Osteoporosis?

2009 ◽  
Vol 24 (8) ◽  
pp. 1354-1357 ◽  
Author(s):  
Glen M Blake ◽  
Juliet E Compston ◽  
Ignac Fogelman
Keyword(s):  
Strontium Ranelate ◽  
Treatment Of Osteoporosis

scholarly journals Sequential treatment with teriparatide and strontium ranelate in a postmenopausal woman with atypical femoral fractures after long-term bisphosphonate administration

HORMONES ◽  
2013 ◽  
Vol 12 (4) ◽  
pp. 591-597 ◽  
Author(s):  
Kalliopi Lampropoulou-Adamidou ◽  
Symeon Tournis ◽  
Alexia Balanika ◽  
Ioulia Antoniou ◽  
Ioannis Stathopoulos ◽  
...  
Keyword(s):  
Postmenopausal Woman ◽  
Strontium Ranelate ◽  
Femoral Fractures ◽  
Sequential Treatment ◽  
Atypical Femoral Fractures
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