scholarly journals The Impact of Surfactant Composition and Surface Charge of Niosomes on the Oral Absorption of Repaglinide as a BCS II Model Drug

2020 ◽  
Vol Volume 15 ◽  
pp. 8767-8781
Author(s):  
Morteza Yaghoobian ◽  
Azadeh Haeri ◽  
Noushin Bolourchian ◽  
Soraya Shahhosseni ◽  
Simin Dadashzadeh
Keyword(s):  
Surface Charge ◽  
Oral Absorption ◽  
Model Drug ◽  
Surfactant Composition ◽  
The Impact

scholarly journals Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
David Da Costa ◽  
Chloé Exbrayat-Héritier ◽  
Basile Rambaud ◽  
Simon Megy ◽  
Raphaël Terreux ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Surface Charge ◽  
Treatment Efficacy ◽  
Particle Migration ◽  
Bacterial Biofilm ◽  
Poly Lactic Acid ◽  
Retention Capacity ◽  
The Impact ◽  
Positively Charged ◽  
Antibiotic Delivery

Abstract Background After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is mostly responsible for chronic infections that current therapeutics fail to cure and it is well-established that novel strategies must be investigated. Particulate drug delivery systems are considered as a promising strategy to face issues related to antibiotic treatments in a biofilm context. Particularly, poly-lactic acid (PLA) nanoparticles present a great interest due to their ability to migrate into biofilms thanks to their submicronic size. However, questions still remain unresolved about their mode of action in biofilms depending on their surface properties. In the current study, we have investigated the impact of their surface charge, firstly on their behavior within a bacterial biofilm, and secondly on the antibiotic delivery and the treatment efficacy. Results Rifampicin-loaded PLA nanoparticles were synthetized by nanoprecipitation and characterized. A high and superficial loading of rifampicin, confirmed by an in silico simulation, enabled to deliver effective antibiotic doses with a two-phase release, appropriate for biofilm-associated treatments. These nanoparticles were functionalized with poly-l-lysine, a cationic peptide, by surface coating inducing charge reversal without altering the other physicochemical properties of these particles. Positively charged nanoparticles were able to interact stronger than negative ones with Staphylococcus aureus, under planktonic and biofilm modes of growth, leading to a slowed particle migration in the biofilm thickness and to an improved retention of these cationic particles in biofilms. While rifampicin was totally ineffective in biofilms after washing, the increased retention capacity of poly-l-lysine-coated rifampicin-loaded PLA nanoparticles has been associated with a better antibiotic efficacy than uncoated negatively charged ones. Conclusions Correlating the carrier retention capacity in biofilms with the treatment efficacy, positively charged rifampicin-loaded PLA nanoparticles are therefore proposed as an adapted and promising approach to improve antibiotic delivery in S. aureus biofilms.

The Impact of Surface Charge on the Mechanical Behavior of High-Porosity Chalk

2012 ◽  
Vol 46 (5) ◽  
pp. 1073-1090 ◽  
Author(s):  
M. Megawati ◽  
A. Hiorth ◽  
M. V. Madland
Keyword(s):  
Mechanical Behavior ◽  
Surface Charge ◽  
High Porosity ◽  
The Impact

The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption

2017 ◽  
Vol 19 (4) ◽  
pp. 1084-1090 ◽  
Author(s):  
Steven C Sutton ◽  
Richard Nause ◽  
Kuan Gandelman
Keyword(s):  
Oral Absorption ◽  
Food Effect ◽  
Gastric Ph ◽  
The Impact

scholarly journals Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 630 ◽  
Author(s):  
Katarzyna Rycerz ◽  
Krzysztof Adam Stepien ◽  
Marta Czapiewska ◽  
Basel T. Arafat ◽  
Rober Habashy ◽  
...  
Keyword(s):  
Dosage Form ◽  
Drug Loading ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Dose Titration ◽  
Step Method ◽  
Needle Size ◽  
Model Drug ◽  
Semi Solid ◽  
The Impact

Embedded three-dimensional printing (e-3DP) is an emerging method for additive manufacturing where semi-solid materials are extruded within a solidifying liquid matrix. Here, we present the first example of employing e-3DP in the pharmaceutical field and demonstrate the fabrication of bespoke chewable dosage forms with dual drug loading for potential use in pediatrics. LegoTM-like chewable bricks made of edible soft material (gelatin-based matrix) were produced by directly extruding novel printing patterns of model drug ink (embedded phase) into a liquid gelatin-based matrix (embedding phase) at an elevated temperature (70 °C) to then solidify at room temperature. Dose titration of the two model drugs (paracetamol and ibuprofen) was possible by using specially designed printing patterns of the embedded phase to produce varying doses. A linearity [R2 = 0.9804 (paracetamol) and 0.9976 (ibuprofen)] was achieved between percentage of completion of printing patterns and achieved doses using a multi-step method. The impact of embedded phase rheological behavior, the printing speed and the needle size of the embedded phase were examined. Owning to their appearance, modular nature, ease of personalizing dose and geometry, and tailoring and potential inclusion of various materials, this new dosage form concept holds a substantial promise for novel dosage forms in pediatrics.

scholarly journals Efficacy of Oral Encochleated Amphotericin B in a Mouse Model of Cryptococcal Meningoencephalitis

mBio ◽  
2019 ◽  
Vol 10 (3) ◽  
Author(s):  
R. Lu ◽  
C. Hollingsworth ◽  
J. Qiu ◽  
A. Wang ◽  
E. Hughes ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cryptococcus Neoformans ◽  
Amphotericin B ◽  
Oral Absorption ◽  
Oral Formulation ◽  
Significant Saving ◽  
Content Type ◽  
Cryptococcal Meningoencephalitis ◽  
Cryptococcal Disease ◽  
The Impact

ABSTRACT Cryptococcus neoformans is an encapsulated yeast responsible for approximately a quarter of a million deaths worldwide annually despite therapy, and upwards of 11% of HIV/AIDS-related deaths, rivaling the impact of tuberculosis and malaria. However, the most effective antifungal agent, amphotericin B, requires intravenous delivery and has significant renal and hematopoietic toxicity, making it difficult to utilize, especially in resource-limited settings. The present studies describe a new nanoparticle crystal encapsulated formulation of amphotericin B known as encochleated amphotericin B (CAmB) that seeks to provide an oral formulation that is low in toxicity and cost. Using a 3-day delayed model of murine cryptococcal meningoencephalitis and a large inoculum of a highly virulent strain of serotype A C. neoformans, CAmB, in combination with flucytosine, was found to have efficacy equivalent to parental amphotericin B deoxycholate with flucytosine and superior to oral fluconazole without untoward toxicity. Transport of fluorescent CAmB particles to brain as well as significant brain levels of amphotericin drug was demonstrated in treated mice, and immunological profiles were similar to those of mice treated with conventional amphotericin B. Additional toxicity studies using a standardized rat model showed negligible toxicity after a 28-day treatment schedule. These studies thus offer the potential for an efficacious oral formulation of a known fungicidal drug against intrathecal cryptococcal disease. IMPORTANCE Cryptococcus neoformans is a significant global fungal pathogen that kills an estimated quarter of a million HIV-infected individuals yearly and has poor outcomes despite therapy. The most effective therapy, amphotericin B, is highly effective in killing the fungus but is available only in highly toxic, intravenous formulations that are unavailable in most of the developing world, where cryptococcal disease in most prevalent. For example, in Ethiopia, reliance on the orally available antifungal fluconazole results in high mortality, even when initiated as preemptive therapy at the time of HIV diagnosis. Thus, alternative agents could result in significant saving of lives. Toward this end, the present work describes the development of a new formulation of amphotericin B (CAmB) that encapsulates the drug as a crystal lipid nanoparticle that facilitates oral absorption and prevents toxicity. Successful oral absorption of the drug was demonstrated in a mouse model that, in combination with the antifungal flucytosine, provided efficacy equal to a parental preparation of amphotericin B plus flucytosine. These studies demonstrate the potential for CAmB in combination with flucytosine to provide an effective oral formulation of a well-known, potent fungicidal drug combination.

Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug

2017 ◽  
Vol 117 ◽  
pp. 333-345 ◽  
Author(s):  
Ajit S. Narang ◽  
Anand Balakrishnan ◽  
John Morrison ◽  
Jinjiang Li ◽  
Jennifer Wang ◽  
...  
Keyword(s):  
Gastrointestinal Motility ◽  
Oral Absorption ◽  
Model Drug

The impact of optically rectified fields on plasmonic electrocatalysis

2019 ◽  
Vol 214 ◽  
pp. 465-477 ◽  
Author(s):  
Darby A. Nelson ◽  
Zachary D. Schultz
Keyword(s):  
Surface Charge ◽  
Optical Rectification ◽  
Electrochemical Reactivity ◽  
Plasmon Resonances ◽  
Altered Surface ◽  
The Impact

Optical rectification of plasmon resonances is shown to induce areas of altered surface charge that affect electrochemical reactivity.

The impact of nano-coating on surface charge accumulation of epoxy resin insulator: characteristic and mechanism

2018 ◽  
Vol 51 (24) ◽  
pp. 245303 ◽  
Author(s):  
Bo Qi ◽  
Chunjia Gao ◽  
Yuzhen Lv ◽  
Chengrong Li ◽  
Youping Tu ◽  
...  
Keyword(s):  
Surface Charge ◽  
Epoxy Resin ◽  
Charge Accumulation ◽  
Nano Coating ◽  
The Impact
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