scholarly journals Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies

2020 ◽  
Vol Volume 15 ◽  
pp. 8921-8931 ◽  
Author(s):  
Amira Yousry Farrah ◽  
Abdulaziz M Al-mahallawi ◽  
Emad B Bashir ◽  
Demiana I Nesseem
Keyword(s):  
Ex Vivo ◽  
Topical Delivery ◽  
Stability Assessment ◽  
Transport Studies ◽  
In Vitro Characterization

Corrigendum to: Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment

2021 ◽  
Vol 9 (3) ◽  
pp. 245-245
Author(s):  
Shivani Verma ◽  
Puneet Utreja
Keyword(s):  
Transdermal Delivery ◽  
Ex Vivo ◽  
In Vitro Characterization ◽  
Research Scholar ◽  
Development In Vitro ◽  
Econazole Nitrate

The authors wish to add words “Research Scholar” and “Research Supervisor” to their affiliations [1]. The original article can be found online at https://doi.org/10.2174/2211738506666180813122102

Voriconazole loaded nanostructured lipid carriers based topical delivery system: QbD based designing, characterization, in-vitro and ex-vivo evaluation

2019 ◽  
Vol 52 ◽  
pp. 303-315 ◽  
Author(s):  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Gautam Singhvi ◽  
Prachi Manchanda ◽  
Neha Hans ◽  
...  
Keyword(s):  
Delivery System ◽  
Ex Vivo ◽  
Topical Delivery ◽  
Nanostructured Lipid Carriers

Development of ethosomal gel of ranolazine for improved topical delivery: In vitro and ex vivo evaluation

2017 ◽  
Vol 225 ◽  
pp. 475-481 ◽  
Author(s):  
Deepak Bisht ◽  
Devina Verma ◽  
Mohd. Aamir Mirza ◽  
Md. Khalid Anwer ◽  
Zeenat Iqbal
Keyword(s):  
Ex Vivo ◽  
Topical Delivery

scholarly journals Fabrication of Transgelosomes for Enhancing the Ocular Delivery of Acetazolamide: Statistical Optimization, In Vitro Characterization, and In Vivo Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 465 ◽  
Author(s):  
Eman A. Mazyed ◽  
Abdelaziz E. Abdelaziz
Keyword(s):  
Ex Vivo ◽  
Entrapment Efficiency ◽  
Tween 80 ◽  
Ocular Delivery ◽  
Ethanol Injection ◽  
In Vitro Characterization ◽  
Span 60 ◽  
In Vivo Characterization

Acetazolamide (ACZ) is a potent carbonic anhydrase inhibitor that is used for the treatment of glaucoma. Its oral administration causes various undesirable side effects. This study aimed to formulate transgelosomes (TGS) for enhancing the ocular delivery of ACZ. ACZ-loaded transfersomes were formulated by the ethanol injection method, using phosphatidylcholine (PC) and different edge activators, including Tween 80, Span 60, and Cremophor RH 40. The effects of the ratio of lipid to surfactant and type of surfactant on % drug released after 8 h (Q8h) and entrapment efficiency (EE%) were investigated by using Design-Expert software. The optimized formula was formulated as TGS, using poloxamers as gelling agents. In vitro and in vivo characterization of ACZ-loaded TGS was performed. According to optimization study, F8 had the highest desirability value and was chosen as the optimized formula for preparing TGS. F8 appeared as spherical elastic nanovesicles with Q8h of 93.01 ± 3.76% and EE% of 84.44 ± 2.82. Compared to a free drug, TGS exhibited more prolonged drug release of 71.28 ± 0.46% after 8 h, higher ex vivo permeation of 66.82 ± 1.11% after 8 h and a significant lowering of intraocular pressure (IOP) for 24 h. Therefore, TGS provided a promising technique for improving the corneal delivery of ACZ.

Do nanoparticles pass the intestinal barrier? Transport studies in vitro and ex vivo

2017 ◽  
Vol 280 ◽  
pp. S188
Author(s):  
Michelle Hesler ◽  
Florian Meier ◽  
Yvonne Kohl
Keyword(s):  
Ex Vivo ◽  
Intestinal Barrier ◽  
Transport Studies
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