scholarly journals Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment

2020 ◽  
Vol Volume 15 ◽  
pp. 4717-4737 ◽  
Author(s):  
Nabil K Alruwaili ◽  
Ameeduzzafar Zafar ◽  
Syed Sarim Imam ◽  
Khalid Saad Alharbi ◽  
Nasser Hadal Alotaibi ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Formulation Optimization ◽  
Stimulus Responsive ◽  
Hydrogel Formulation ◽  
Ocular Safety

Development and Evaluation of Nanoparticle-Loaded Hydrogel of Co-trimoxazole

1970 ◽  
Vol 9 (1) ◽  
pp. 3131-3141
Author(s):  
Prajeesh Kumar ◽  
Raj K. Narang ◽  
Shivansh Swamy
Keyword(s):  
Chitosan Nanoparticles ◽  
Entrapment Efficiency ◽  
Wound Dressings ◽  
Control Group ◽  
Sustained Drug Release ◽  
Accelerate Wound Healing ◽  
Carbopol 940 ◽  
Hydrogel Formulation ◽  
Average Size ◽  
Study Development

In this study, development of nanoparticle loaded hydrogel of Cotrimoxazole that could simultaneously deliver trimethoprim and sulfamethoxazole at the site of wound to promote and accelerate wound healing is planned. Chitosan nanoparticles loaded with Co-trimoxazole were prepared by ionic gelation method. Chitosan nanoparticles were optimized and F5 formulation was selected 5:1 Chitosan TPP ratio for this Homogenization speed was kept at 5000 rpm and an average size of 209.8 ± 34.6 was obtained, PDI was found to be 0.26 ± 0.04, the zeta potential of the nanoparticles was found to be + 24.7 ± 3.12 and the entrapment efficiency of 89.7 ± 3.1 % was seen. Hydrogel was prepared and optimized on the basis of Conc. of Carbopol 940 1.2%, viscosity 14.953 ± 0.51, pH 5.9 ± 0.04, Swelling index 250 ± 4.71 and Spreadability 34 ± 3.5. Antimicrobial study and Minimum Inhibitory Concentration (MIC) were performed and it was observed that the MIC of Co-trimoxazole was 2 µg/mL and the hydrogel formulation showed maximum zone of inhibition 3.7 ± 0.3 after 72 hours against plain drug and marketed formulation. The rate of wound contraction was calculated in percentage and at 15th day the control group had 72% ± 3.9%, Marketed formulation group had 36% ± 5.2% and the hydrogel formulation had reduced the wound size to mere 4% ± 1.3% only. Hydrogel loaded with nanoparticles of Co-trimoxazole that possessed optimum rheology and provided sustained drug release was successfully prepared. The developed hydrogel formulation was found to heal the wound 1.5 times faster than the marketed formulation thus providing us with a better alternative to other conventional wound dressings.

Chitosan Nanoparticles of Gamma-Oryzanol: Formulation, Optimization, and In vivo Evaluation of Anti-hyperlipidemic Activity

2018 ◽  
Vol 19 (4) ◽  
pp. 1894-1907 ◽  
Author(s):  
Tejal Rawal ◽  
Neha Mishra ◽  
Abhishek Jha ◽  
Apurva Bhatt ◽  
Rajeev K. Tyagi ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Evaluation ◽  
Formulation Optimization ◽  
Gamma Oryzanol

Evaluation of Alginate/Chitosan nanoparticles as antisense delivery vector: Formulation, optimization and in vitro characterization

2009 ◽  
Vol 77 (3) ◽  
pp. 599-606 ◽  
Author(s):  
Tarane Gazori ◽  
Mohammad Reza Khoshayand ◽  
Ebrahim Azizi ◽  
Parisa Yazdizade ◽  
Alireza Nomani ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Formulation Optimization ◽  
Delivery Vector ◽  
In Vitro Characterization

Toxicological evaluation of xanthan gum based hydrogel formulation in Wistar rats using single dose study

2020 ◽  
Vol 77 (2) ◽  
pp. 353-360
Author(s):  
Nadia Malik ◽  
Mahmood Ahmad ◽  
Muhammad Minhas ◽  
Ruqia Tulain ◽  
Ikrima Khalid ◽  
...  
Keyword(s):  
Single Dose ◽  
Xanthan Gum ◽  
Wistar Rats ◽  
Toxicological Evaluation ◽  
Single Dose Study ◽  
Dose Study ◽  
Hydrogel Formulation

Optimization and Physicochemical Characterization of Chitosan and Chitosan Nanoparticles Extracted from the Crayfish Procambarus clarkii Wastes

2019 ◽  
Vol 38 (2) ◽  
pp. 385 ◽  
Author(s):  
Marwa M. El-Naggar ◽  
Wael S. I. Abou-Elmagd ◽  
Ashraf Suloma ◽  
Hamza A. El-Shabaka ◽  
Magdy T. Khalil ◽  
...  
Keyword(s):  
Procambarus Clarkii ◽  
Chitosan Nanoparticles ◽  
Physicochemical Characterization
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