scholarly journals Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats

2011 ◽  
pp. 2327 ◽  
Author(s):  
Siva Krishna Nalabotu ◽  
Kolli ◽  
Triest ◽  
Ma ◽  
Manne ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Intratracheal Instillation ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Hepatic Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Spleen data: Cerium oxide nanoparticles attenuate polymicrobial sepsis induced spenic damage in male Sprague Dawley rats

Data in Brief ◽  
2018 ◽  
Vol 18 ◽  
pp. 740-746 ◽  
Author(s):  
Kevin M. Rice ◽  
Venkata Vinay Kumar Bandarupalli ◽  
Nandini D.P.K. Manne ◽  
Eric R. Blough
Keyword(s):  
Cerium Oxide ◽  
Polymicrobial Sepsis ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats

2015 ◽  
Vol 43 (11) ◽  
pp. e477-e489 ◽  
Author(s):  
Nandini D. P. K. Manne ◽  
Ravikumar Arvapalli ◽  
Niraj Nepal ◽  
Srinivasarao Thulluri ◽  
Vellaisamy Selvaraj ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Therapeutic Potential ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Induction of Inflammatory Responses in Mice Treated with Cerium Oxide Nanoparticles by Intratracheal Instillation

2010 ◽  
Vol 56 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Eun-Jung Park ◽  
Wan-Seob Cho ◽  
Jayoung Jeong ◽  
Jong-heop Yi ◽  
Kyunghee Choi ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Inflammatory Responses ◽  
Intratracheal Instillation ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Safety assessment of cerium oxide nanoparticles: Combined repeated-dose toxicity with reproductive/developmental toxicity screening and biodistribution in rats

2019 ◽  
Author(s):  
Jinsoo Lee ◽  
Ji-Seong Jeong ◽  
Sang Yun Kim ◽  
Seung-Jin Lee ◽  
Young-Jun Shin ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Safety Assessment ◽  
Developmental Toxicity ◽  
Real Life ◽  
Repeated Dose ◽  
Oral Exposure ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicity Screening ◽  
Sprague Dawley

Abstract Background Cerium oxide nanoparticles (CeO 2 NPs) are widely used in various commercial applications because of their characteristic properties. CeO 2 NPs can be easily exposed to humans in real life, but the safety assessment of CeO 2 NPs has not been fully investigated. Therefore, in this study, we conducted a combined repeated-dose and reproductive/developmental toxicity screening study to investigate the potential effects on general health hazards, including reproductive/developmental functions, after repeated CeO 2 NPs oral exposure. In addition, tissues from parental animals and their pups were collected to analyze the internal accumulation of cerium. CeO 2 NPs were orally administered to Sprague-Dawley rats at doses of 0, 100, 300 and 1000 mg/kg during their pre-mating, mating, gestation and early lactation periods. Results In the general systemic and reproductive/developmental examinations, no marked toxicities were observed in any of in-life and terminal observation parameters in this study. In the biodistribution analysis, cerium was not detected in either parental or pup tissues (blood, liver, lungs and kidneys). Conclusion Repeated oral exposure of CeO 2 NPs did not induce marked toxicities affecting general systemic and reproductive/developmental functions up to the dose level of 1000 mg/kg and the CeO 2 NPs were not systemically absorbed in parental animals or their pups. This result could be used to risk assessment for human, and additional toxicity studies with CeO 2 NPs will be necessary considering various physicochemical properties and exposure probabilities of this nanoparticles.

scholarly journals The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice

2017 ◽  
Vol Volume 12 ◽  
pp. 2913-2922 ◽  
Author(s):  
Abderrahim Nemmar ◽  
Suhail Al-Salam ◽  
Sumaya Beegam ◽  
Priya Yuvaraju ◽  
Badreldin H Ali
Keyword(s):  
Cerium Oxide ◽  
Intratracheal Instillation ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles
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