scholarly journals Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer

2020 ◽  
Vol Volume 15 ◽  
pp. 2659-2668
Author(s):  
Peng Xu ◽  
Jia Yao ◽  
Zhen Li ◽  
Meng Wang ◽  
Linghui Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Therapeutic Effect ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mesoporous Silica Nanoparticles ◽  
Chlorin E6

MUC1 Aptamer‐Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple‐Negative Breast Cancer

2020 ◽  
Vol 26 (69) ◽  
pp. 16318-16327 ◽  
Author(s):  
Gema Vivo‐Llorca ◽  
Vicente Candela‐Noguera ◽  
María Alfonso ◽  
Alba García‐Fernández ◽  
Mar Orzáez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mesoporous Silica Nanoparticles ◽  
Muc1 Aptamer

Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy

2020 ◽  
Vol 8 (10) ◽  
pp. 2939-2954 ◽  
Author(s):  
Manisha Ahir ◽  
Priyanka Upadhyay ◽  
Avijit Ghosh ◽  
Sushmita Sarker ◽  
Saurav Bhattacharya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Triple Negative Breast Cancer ◽  
Conjugated Polymer ◽  
Triple Negative ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Breast Cancer Therapy ◽  
Mesoporous Silica Nanoparticle ◽  
Efficient Delivery

Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.

scholarly journals Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

2015 ◽  
Vol 25 (18) ◽  
pp. 2646-2659 ◽  
Author(s):  
Worapol Ngamcherdtrakul ◽  
Jingga Morry ◽  
Shenda Gu ◽  
David J. Castro ◽  
Shaun M. Goodyear ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Cationic Polymer ◽  
Her2 Breast Cancer

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

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