scholarly journals Ionically Cross-Linked Chitosan Nanoparticles for Sustained Delivery of Docetaxel: Fabrication, Post-Formulation and Acute Oral Toxicity Evaluation

2019 ◽  
Vol Volume 14 ◽  
pp. 10035-10046 ◽  
Author(s):  
Muhammad Ahmad Mahmood ◽  
Asadullah Madni ◽  
Mubashar Rehman ◽  
Muhammad Abdur Rahim ◽  
Abdul Jabar
Keyword(s):  
Chitosan Nanoparticles ◽  
Sustained Delivery ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity

scholarly journals Acute oral toxicity evaluation of Andrographis paniculata-standardized first true leaf ethanolic extract

2019 ◽  
Vol 6 ◽  
pp. 426-430 ◽  
Author(s):  
Luksamee Worasuttayangkurn ◽  
Watanyoo Nakareangrit ◽  
Jackapun Kwangjai ◽  
Pishyaporn Sritangos ◽  
Nanthanit Pholphana ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Andrographis Paniculata ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity ◽  
True Leaf

Acute Oral Toxicity Evaluation of JA-2 Solid Propellant

1993 ◽  
Vol 12 (6) ◽  
pp. 584-585
Author(s):  
L. D. Brown ◽  
D. W. Korte ◽  
J. D. Justus ◽  
C. R. Wheeler ◽  
E. W. Morgan ◽  
...  
Keyword(s):  
Solid Propellant ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity

scholarly journals Utilization of Gelling Polymer to Formulate Nanoparticles Loaded with Epalrestat-Cyclodextrin Inclusion Complex: Formulation, Characterization, In-Silico Modelling and In-Vivo Toxicity Evaluation

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4350
Author(s):  
Zunaira Alvi ◽  
Muhammad Akhtar ◽  
Nisar U. Rahman ◽  
Khaled M. Hosny ◽  
Amal M. Sindi ◽  
...  
Keyword(s):  
In Silico ◽  
Sodium Tripolyphosphate ◽  
Polymeric Nanoparticles ◽  
Chitosan Nanoparticles ◽  
Chemical Properties ◽  
Aqueous Solubility ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Cross Linker

Epalrestat (EPL) is an aldose reductase inhibitor with poor aqueous solubility that affects its therapeutic efficacy. The research study was designed to prepare epalrestat-cyclodextrins (EPL-CDs) inclusion complexes to enhance the aqueous solubility by using beta-cyclodextrin (β-CD) and sulfobutyl ether₇ β-CD (SBE7 β-CD). Furthermore, polymeric nanoparticles (PNPs) of EPL-CDs were developed using chitosan (CS) and sodium tripolyphosphate (sTPP). The EPL-CDs complexed formulations were then loaded into chitosan nanoparticles (CS NPs) and further characterized for different physico-chemical properties, thermal stability, drug-excipient compatibility and acute oral toxicity studies. In-silico molecular docking of cross-linker with SBE7 β-CD was also carried out to determine the binding site of the CDs with the cross-linker. The sizes of the prepared NPs were laid in the range of 241.5–348.4 nm, with polydispersity index (PDI) ranging from 0.302–0.578. The surface morphology of the NPs was found to be non-porous, smooth, and spherical. The cumulative percentage of drug release from EPL-CDs loaded CS NPs was found to be higher (75–88%) than that of the pure drug (25%). Acute oral toxicity on animal models showed a biochemical, histological profile with no harmful impact at the cellular level. It is concluded that epalrestat-cyclodextrin chitosan nanoparticles (EPL-CDs-CS NPs) with improved solubility are safe for oral administration since no toxicity was reported on vital organs in rabbits.

scholarly journals Acute oral toxicity evaluation of extracts of Hydrocotyle sibthorpioides in wister albino rats as per OECD 425 TG

2019 ◽  
Vol 6 ◽  
pp. 321-328 ◽  
Author(s):  
Iswar Hazarika ◽  
K.M. Geetha ◽  
P. Sivakami Sundari ◽  
Divya Madhu
Keyword(s):  
Albino Rats ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity

Acute Oral Toxicity Evaluation of Some Polyherbal Formulations in Albino Wistar Rats

2008 ◽  
Vol 4 (5) ◽  
pp. 388-392 ◽  
Author(s):  
A.J. Joshua ◽  
K.S. Goudar ◽  
A. Damodaran ◽  
N. Sameera ◽  
A. Amit
Keyword(s):  
Wistar Rats ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity

scholarly journals Acute oral toxicity evaluation of aqueous ethanolic extract of Saccharum munja Roxb. roots in albino mice as per OECD 425 TG

2017 ◽  
Vol 4 ◽  
pp. 580-585 ◽  
Author(s):  
Uzma Saleem ◽  
Sadia Amin ◽  
Bashir Ahmad ◽  
Haroon Azeem ◽  
Fareeha Anwar ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity ◽  
Aqueous Ethanolic Extract ◽  
Albino Mice ◽  
Saccharum Munja

scholarly journals Acute and Sub-Acute Oral Toxicity Evaluation of Astragalus hamosus Seedpod Ethanolic Extract in Wistar Rats

2018 ◽  
Vol 24 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Mohammadmehdi Hassanzadeh-Taheri ◽  
Mehran Hosseini ◽  
Mojtaba Salimi ◽  
Hesam Moodi ◽  
Davood Dorranpour
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity

Acute Oral Toxicity Evaluation of JA-2 Solid Propellant

1993 ◽  
Vol 12 (6) ◽  
pp. 584-585
Author(s):  
LD Brown ◽  
DW Korte ◽  
JD Justus ◽  
CR Wheeler ◽  
EW Morgan ◽  
...  
Keyword(s):  
Solid Propellant ◽  
Acute Oral Toxicity ◽  
Toxicity Evaluation ◽  
Oral Toxicity
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