scholarly journals Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: characterization, lyophilization and in-vivo evaluation

2019 ◽  
Vol Volume 14 ◽  
pp. 4895-4909 ◽  
Author(s):  
Jahanzeb Mudassir ◽  
Yusrida Darwis ◽  
Suriani Muhamad ◽  
Arshad Ali Khan
Keyword(s):  
Polyelectrolyte Complex ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
In Vivo Evaluation ◽  
Self Assembled

In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (12) ◽  
pp. 2329-2339 ◽  
Author(s):  
Kiran Sonaje ◽  
Yu-Hsin Lin ◽  
Jyuhn-Huarng Juang ◽  
Shiaw-Pyng Wey ◽  
Chiung-Tong Chen ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin ◽  
In Vivo Evaluation ◽  
Safety And Efficacy ◽  
Self Assembled

Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model

2013 ◽  
Vol 33 (1) ◽  
pp. 376-382 ◽  
Author(s):  
Piyasi Mukhopadhyay ◽  
Kishor Sarkar ◽  
Mousumi Chakraborty ◽  
Sourav Bhattacharya ◽  
Roshnara Mishra ◽  
...  
Keyword(s):  
Animal Model ◽  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Diabetic Animal ◽  
In Vivo Studies ◽  
Oral Insulin ◽  
Self Assembled

Thiolated Eudragit nanoparticles for oral insulin delivery: Preparation, characterization and in vivo evaluation

2012 ◽  
Vol 436 (1-2) ◽  
pp. 341-350 ◽  
Author(s):  
Yan Zhang ◽  
Xiaorong Wu ◽  
Lingkuo Meng ◽  
Yu Zhang ◽  
Ruiting Ai ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin ◽  
In Vivo Evaluation

In Vivo Evaluation of Thiolated Chitosan Tablets for Oral Insulin Delivery

2014 ◽  
Vol 103 (10) ◽  
pp. 3165-3170 ◽  
Author(s):  
Gioconda Millotti ◽  
Flavia Laffleur ◽  
Glen Perera ◽  
Claudia Vigl ◽  
Karin Pickl ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan

scholarly journals In vivo oral insulin delivery via covalent organic frameworks

2021 ◽  
Author(s):  
Farah Benyettou ◽  
Nawel Kaddour ◽  
Thirumurugan Prakasam ◽  
Gobinda Das ◽  
Sudhir Kumar Sharma ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Covalent Organic Frameworks ◽  
Covalent Organic Framework ◽  
Organic Framework

We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin.

In Vivo Evaluation of a Nasal Insulin Delivery System Based on Thiolated Chitosan

2006 ◽  
Vol 95 (11) ◽  
pp. 2463-2472 ◽  
Author(s):  
Alexander H. Krauland ◽  
Verena M. Leitner ◽  
Vjera Grabovac ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan ◽  
Insulin Delivery System

scholarly journals Optimized Chitosan/Anion Polyelectrolyte Complex Based Inserts for Vaginal Delivery of Fluconazole: In Vitro/In Vivo Evaluation

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 227 ◽  
Author(s):  
Bayan Darwesh ◽  
Hibah Aldawsari ◽  
Shaimaa Badr-Eldin
Keyword(s):  
Vaginal Delivery ◽  
Polyelectrolyte Complex ◽  
Inflammatory Cells ◽  
Antifungal Drugs ◽  
Vaginal Candidiasis ◽  
Histological Evaluation ◽  
Anionic Polymer ◽  
In Vivo Evaluation

(1) Background: Fluconazole, used orally for vaginal candidiasis, has reported gastrointestinal side effects. Therefore, researchers directed towards the drug vaginal delivery. However, vaginal delivery is limited by poor retention and leakage. Thus, this work aimed at exploring chitosan/anion polyelectrolyte complex (PEC) for the formulation of fluconazole vaginal inserts with controlled release and appreciable mucoadhesion. (2) Methods: PECs were prepared and assessed for interactions. Fluconazole PEC based vaginal inserts were prepared by lyophilization using mannitol. 3151 factorial design was applied to investigate the effect of the anion type and Chitosan/anion ratio on the inserts mucoadhesion and release properties. The optimized insert [based on 5:5 chitosan: anionic polymer (sodium alginate)] release was modulated by the release retardant; Compritol® 888. The selected formulation was subjected to microbiological and histological evaluation. (3) Results: Fluconazole inserts showed satisfactory drug content, acceptable friability percentages and highest swelling indices at six hours. Statistical analysis showed significant effect of the studied factors on detachment force and release properties. Microbiological assays revealed significantly higher antifungal activity of inserts compared to fluconazole solution. Reduced inflammatory cells were confirmed by histological evaluation. (4) Conclusion: CH/Alg based vaginal insert could be a promising platform for vaginal delivery of antifungal drugs used for vaginal candidiasis treatment.

scholarly journals In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures

2016 ◽  
Vol 13 (7) ◽  
pp. 2193-2203 ◽  
Author(s):  
Rachit Shah ◽  
Jacob Petersburg ◽  
Amit C. Gangar ◽  
Adrian Fegan ◽  
Carston R. Wagner ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Self Assembled
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