scholarly journals A nano-sized blending system comprising identical triblock copolymers with different hydrophobicity for fabrication of an anticancer drug nanovehicle with high stability and solubilizing capacity

2019 ◽  
Vol Volume 14 ◽  
pp. 3629-3644 ◽  
Author(s):  
Ngoc Ha Hoang ◽  
Taehoon Sim ◽  
Chaemin Lim ◽  
Thi Ngoc Le ◽  
Sang Myung Han ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
High Stability ◽  
Triblock Copolymers ◽  
Solubilizing Capacity

Enhanced stability of crosslinked and charged unimolecular micelles from multigeometry triblock copolymers with short hydrophilic segments: dissipative particle dynamics simulation

Soft Matter ◽  
2019 ◽  
Vol 15 (4) ◽  
pp. 546-558 ◽  
Author(s):  
Jianchang Xu ◽  
Jing Zhang ◽  
Di Xiong ◽  
Wenjing Lin ◽  
Liyang Wen ◽  
...  
Keyword(s):  
High Stability ◽  
Triblock Copolymers ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
Dynamics Simulation ◽  
Supramolecular Polymers ◽  
Electrostatic Repulsion ◽  
Dissipative Particle Dynamics Simulation ◽  
Enhanced Stability

The synergetic stabilization strategy of crosslinking and electrostatic repulsion can generate unimolecular micelles with extremely high stability for various supramolecular polymers with short hydrophilic chains.

Anticancer drug discovery from filamentous fungi

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
NH Oberlies ◽  
A Sy ◽  
TN Graf ◽  
DJ Kroll ◽  
Y Nakanishi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Filamentous Fungi ◽  
Anticancer Drug ◽  
Anticancer Drug Discovery

Development of Taxol® as an anticancer drug

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DGI Kingston
Keyword(s):  
Anticancer Drug

Self-Assembly of Hydrogels From Elastin-Mimetic Block Copolymers

2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Variable Temperature ◽  
Inverse Temperature ◽  
Temperature Transition ◽  
Scanning Calorimetry ◽  
Design Synthesis ◽  
Inverse Temperature Transition ◽  
Functional Biomaterials

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.

Multiscale Simulations of Triblock Copolymers

2007 ◽  
Vol 5 (3-4) ◽  
pp. 167-179 ◽  
Author(s):  
Jan Andzelm ◽  
Frederick L. Beyer ◽  
James Snyder ◽  
Peter W. Chung
Keyword(s):  
Triblock Copolymers ◽  
Multiscale Simulations
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