scholarly journals G1-S4 or G2-S16 carbosilan dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity

2019 ◽  
Vol Volume 14 ◽  
pp. 2371-2381 ◽  
Author(s):  
Rafael Ceña-Diez ◽  
Alba Martin-Moreno ◽  
F Javier de la Mata ◽  
Rafael Gómez-Ramirez ◽  
Eduardo Muñoz ◽  
...  
Keyword(s):  
Platycodin D ◽  
Vaginal Microbicide ◽  
Contraceptive Activity ◽  
Microbicide Candidate

scholarly journals Preclinical assessments of vaginal microbicide candidate safety and efficacy

2015 ◽  
Vol 92 ◽  
pp. 27-38 ◽  
Author(s):  
José A. Fernández-Romero ◽  
Natalia Teleshova ◽  
Thomas M. Zydowsky ◽  
Melissa Robbiani
Keyword(s):  
Safety And Efficacy ◽  
Vaginal Microbicide ◽  
Microbicide Candidate

scholarly journals Evaluation of the Spermicidal and Contraceptive Activity of Platycodin D, a Saponin from Platycodon grandiflorum

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e82068 ◽  
Author(s):  
Zongliang Lu ◽  
Leiguang Wang ◽  
Rui Zhou ◽  
Yi Qiu ◽  
Liuna Yang ◽  
...  
Keyword(s):  
Platycodon Grandiflorum ◽  
Platycodin D ◽  
Contraceptive Activity

Safety and acceptability of a vaginal microbicide

2009 ◽  
Author(s):  
Sharon Hillier ◽  
Jessica Justman ◽  
Smita N. Joshi ◽  
Craig Hoesley
Keyword(s):  
Vaginal Microbicide

scholarly journals A candidate gene identified in converting platycoside E to platycodin D from Platycodon grandiflorus by transcriptome and main metabolites analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinglong Su ◽  
Yingying Liu ◽  
Lu Han ◽  
Zhaojian Wang ◽  
Mengyang Cao ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Orthogonal Experiment ◽  
Triterpenoid Saponin ◽  
Gene Encoding ◽  
Triterpenoid Saponins ◽  
Platycodin D ◽  
Polysaccharide Content ◽  
Saponin Biosynthesis ◽  
Polysaccharide Synthesis ◽  
Experimental Use

AbstractPlatycodin D and platycoside E are two triterpenoid saponins in Platycodon grandiflorus, differing only by two glycosyl groups structurally. Studies have shown β-Glucosidase from bacteria can convert platycoside E to platycodin D, indicating the potential existence of similar enzymes in P. grandiflorus. An L9(34) orthogonal experiment was performed to establish a protocol for calli induction as follows: the optimal explant is stems with nodes and the optimum medium formula is MS + NAA 1.0 mg/L + 6-BA 0.5 mg/L to obtain callus for experimental use. The platycodin D, platycoside E and total polysaccharides content between callus and plant organs varied wildly. Platycodin D and total polysaccharide content of calli was found higher than that of leaves. While, platycoside E and total polysaccharide content of calli was found lower than that of leaves. Associating platycodin D and platycoside E content with the expression level of genes involved in triterpenoid saponin biosynthesis between calli and leaves, three contigs were screened as putative sequences of β-Glucosidase gene converting platycoside E to platycodin D. Besides, we inferred that some transcription factors can regulate the expression of key enzymes involved in triterpernoid saponins and polysaccharides biosynthesis pathway of P. grandiflorus. Totally, a candidate gene encoding enzyme involved in converting platycoside E to platycodin D, and putative genes involved in polysaccharide synthesis in P. grandiflorus had been identified. This study will help uncover the molecular mechanism of triterpenoid saponins biosynthesis in P. grandiflorus.

In vitro and in vivo evaluation of a water‐in‐oil microemulsion of platycodin D

2021 ◽  
Author(s):  
Jinyang Shen ◽  
Yuexia Zhu ◽  
Bingxue Zhou ◽  
Li Kong ◽  
Ye Jin ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Platycodin D

scholarly journals Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation

2021 ◽  
Author(s):  
Sol Ji Lee ◽  
Yu‐Jeong Choi ◽  
Hyo In Kim ◽  
Hyo Eun Moon ◽  
Sun Ha Paek ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioblastoma Cell ◽  
Platycodin D

scholarly journals P3.364 Does Tenofovir Gel - or Do Other Vaginal Microbicide Products - Affect Detection of Biomarkers of Semen Exposure?

2013 ◽  
Vol 89 (Suppl 1) ◽  
pp. A263.1-A263
Author(s):  
M C Snead ◽  
A P Kourtis ◽  
J H Melendez ◽  
C M Black ◽  
C K Mauck ◽  
...  
Keyword(s):  
Vaginal Microbicide ◽  
Affect Detection ◽  
Tenofovir Gel ◽  
Detection Of Biomarkers

scholarly journals Anti-Inflammatory Activities of Compounds Isolated from the Rhizome of Anemarrhena asphodeloides

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2631 ◽  
Author(s):  
Zeyuan Wang ◽  
Jianfeng Cai ◽  
Qing Fu ◽  
Lingping Cheng ◽  
Lehao Wu ◽  
...  
Keyword(s):  
Nuclear Factor Κb ◽  
Microglial Cells ◽  
No Production ◽  
Dependent Manner ◽  
Platycodin D ◽  
Protein Levels ◽  
Chemical Structures ◽  
Ic50 Values ◽  
Anti Inflammatory ◽  
Anemarrhena Asphodeloides

Fifteen unreported compounds in Anemarrhena asphodeloides, iriflophene (3), hostaplantagineoside C (7), tuberoside G (8), spicatoside B (9), platycodin D (14), platycoside A (15), platycodin D2 (16), polygalacin D2 (17), platycodin D3 (18), isovitexin (20), vitexin (21), 3,4-dihydroxyallylbenzene-3-O-α-l-rhamnopyranosyl(1→6)-β-d-glucopyranoside (22), iryptophan (24), adenosine (25), α-d-Glucose monoallyl ether (26), together with eleven known compounds (1, 2, 4–6, 10–13, 19 and 23), were isolated from the rhizomes of Anemarrhena asphodeloides. The chemical structures of these compounds were characterized using HRMS and NMR. The anti-inflammatory activities of the compounds were evaluated by investigating their ability to inhibit LPS-induced NO production in N9 microglial cells. Timosaponin BIII (TBIII) and trans-hinokiresinol (t-HL) exhibited significant inhibitory effects on the NO production in a dose-dependent manner with IC50 values of 11.91 and 39.08 μM, respectively. Immunoblotting demonstrated that TBIII and t-HL suppressed NO production by inhibiting the expressions of iNOS in LPS-stimulated N9 microglial cells. Further results revealed that pretreatment of N9 microglial cells with TBIII and t-HL attenuated the LPS-induced expression tumor necrosis factor (TNF)-α and interleukin-6 (IL-6) at mRNAs and protein levels. Moreover, the activation of nuclear factor-κB (NF-κB) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways were inhibited by TBIII and t-HL, respectively. Our findings indicate that the therapeutic implication of TBIII and t-HL for neurogenerative disease associated with neuroinflammation.

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