scholarly journals Graphene quantum dots-gated hollow mesoporous carbon nanoplatform for targeting drug delivery and synergistic chemo-photothermal therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 5991-6007 ◽  
Author(s):  
Junfeng Fang ◽  
Yanqing Liu ◽  
Yiwen Chen ◽  
Dimei Ouyang ◽  
Guangji Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Photothermal Therapy ◽  
Mesoporous Carbon ◽  
Graphene Quantum Dots

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

scholarly journals Incorporation of Graphene Quantum Dots, Iron, and Doxorubicin in/on Ferritin Nanocages for Bimodal Imaging and Drug Delivery

2020 ◽  
Vol 3 (3) ◽  
pp. 1900183 ◽  
Author(s):  
Fatemeh Nasrollahi ◽  
Barindra Sana ◽  
David Paramelle ◽  
Samad Ahadian ◽  
Ali Khademhosseini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Bimodal Imaging

Graphene Quantum Dots-Coated Bismuth Nanoparticles for Improved CT Imaging and Photothermal Performance

2018 ◽  
Vol 19 (01) ◽  
pp. 1850043 ◽  
Author(s):  
Samireh Badrigilan ◽  
Behrouz Shaabani ◽  
Nahideh Ghareh Aghaji ◽  
Asghar Mesbahi
Keyword(s):  
Quantum Dots ◽  
Photothermal Therapy ◽  
High Performance ◽  
Blood Compatibility ◽  
Graphene Quantum Dots ◽  
Ct Imaging ◽  
Bismuth Nanoparticles ◽  
Contrast Ct ◽  
Absorbance Profile

By integrating high-performance CT imaging and photothermal therapy (PTT) into one nanoprobe, an effective theranostic can be achieved for clinical cancer treatment. In this study, the graphene quantum dots (GQDs)-coated bismuth (Bi) nanoparticle (NP) as a theranostic nanoprobe is synthesized and its capabilities for computed tomography (CT) imaging and PTT are investigated. Such nanotheranostic exhibits good physiological dispersity with satisfactory blood compatibility and cytotoxicity. Most importantly, the GQDs-Bi NPs offer strong and steady absorbance profile in NIR region with excellent photostability, which can remarkably convert photo-to-thermal with the photothermal efficiency of 30.0%. Thanks to the powerful PTT effect, co-delivery of GQDs-Bi NPs/NIR laser can effectively induce HeLa cells death in vitro. Cooperatively, NPs hold X-ray attenuation coefficient for high-contrast CT imaging with the corresponding CT improvement efficacy as high as 32.7[Formula: see text]HU[Formula: see text]mg[Formula: see text]. The obtained results highlight the potential of GQDs-Bi NPs as a successful theranostic nanoagent for CT imaging and cancer photothermal therapy.

Mesoporous carbon/CuS nanocomposites for pH-dependent drug delivery and near-infrared chemo-photothermal therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (113) ◽  
pp. 93226-93233 ◽  
Author(s):  
Lei Zhang ◽  
Yecheng Li ◽  
Zexun Jin ◽  
King Ming Chan ◽  
Jimmy C. Yu
Keyword(s):  
Drug Delivery ◽  
Photothermal Therapy ◽  
Mesoporous Carbon ◽  
Near Infrared ◽  
Ph Dependent

Illustration of both pH- and NIR-controlled drug deliveries using DOX loaded MCN–CuS nanocomposites and their application in cancer chemo-photothermal therapy.

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