scholarly journals Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

2018 ◽  
Vol Volume 13 ◽  
pp. 5887-5907 ◽  
Author(s):  
Yao-Xing Dou ◽  
Jiang-Tao Zhou ◽  
Tong-Tong Wang ◽  
Yan-Feng Huang ◽  
Ping Chen ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Approach

scholarly journals 5-ASA-loaded SiO2 nanoparticles-a novel drug delivery system targeting therapy on ulcerative colitis in mice

2017 ◽  
Vol 15 (3) ◽  
pp. 1117-1122 ◽  
Author(s):  
Haiying Tang ◽  
Dan Xiang ◽  
Feng Wang ◽  
Jingwei Mao ◽  
Xiaoyan Tan ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sio2 Nanoparticles ◽  
Targeting Therapy ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1412
Author(s):  
Murtada A. Oshi ◽  
Juho Lee ◽  
Jihyun Kim ◽  
Nurhasni Hasan ◽  
Eunok Im ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cyclosporine A ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Systemic Absorption ◽  
Systemic Side Effects

Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated alginate microparticles (CsAc-EAMPs) was established to minimize systemic side effects and enhance the therapeutic efficacy of CsA. Homogeneously-sized CsAs (3.1 ± 0.9 μm) were prepared by anti-solvent precipitation, followed by the fabrication of 47.1 ± 6.5 μm-sized CsAc-EAMPs via ionic gelation and ES coating. CsAc-EAMPs exhibited a high drug loading capacity (48 ± 5%) and a CsA encapsulation efficacy of 77 ± 9%. The in vitro drug release study revealed that CsA release from CsAc-EAMPs was suppressed under conditions simulating the stomach and small intestine, resulting in minimized systemic absorption and side effects. Following exposure to the simulated colon conditions, along with ES dissolution and disintegration of alginate microparticles, CsA was released from CsAc-EAMPs, exhibiting a sustained-release profile for up to 24 h after administration. Given the effective colonic delivery of CsA molecules, CsAc-EAMPs conferred enhanced anti-inflammatory activity in mouse model of dextran sulfate sodium (DSS)-induced colitis. These findings suggest that CsAc-EAMPs is a promising drug delivery system for treating UC.

scholarly journals FLOATING A NEW APPROACH FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

2020 ◽  
Vol 9 (2) ◽  
pp. 1
Author(s):  
Kusum Sharma ◽  
Asit Ranjan Sahu ◽  
Ankita Srivastava ◽  
Ruchi Shukla ◽  
Komal Rahevar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Approach ◽  
System A

scholarly journals Oral dispersible system: A new approach in drug delivery system

2016 ◽  
Vol 78 (1) ◽  
pp. 2 ◽  
Author(s):  
PA Hannan ◽  
JA Khan ◽  
A Khan ◽  
S Safiullah
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Approach ◽  
System A
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