scholarly journals Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus

2018 ◽  
Vol Volume 13 ◽  
pp. 6829-6837 ◽  
Author(s):  
Jun Xu ◽  
Lijun Cao ◽  
Yuan Suo ◽  
Xiaoqin Xu ◽  
Hui Sun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cox 2 ◽  
Microcirculation Dysfunction ◽  
Mesenteric Microcirculation

scholarly journals Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies

2018 ◽  
Vol 19 (11) ◽  
pp. 3665 ◽  
Author(s):  
Nada Sallam ◽  
Victoria Palmgren ◽  
Radha Singh ◽  
Cini John ◽  
Jennifer Thompson
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Gestational Diabetes ◽  
Vascular Dysfunction ◽  
Endothelial Activation ◽  
Intrauterine Environment ◽  
Cox 2 ◽  
Diabetic Mothers

With the rising global tide of obesity, gestational diabetes mellitus (GDM) burgeoned into one of the most common antenatal disorders worldwide. Macrosomic babies born to diabetic mothers are more likely to develop risk factors for cardiovascular disease (CVD) before they reach adulthood. Rodent studies in offspring born to hyperglycemic pregnancies show vascular dysfunction characterized by impaired nitric oxide (NO)-mediated vasodilation and increased production of contractile prostanoids by cyclooxygenase 2 (COX-2). Vascular dysfunction is a key pathogenic event in the progression of diabetes-related vascular disease, primarily attributable to glucotoxicity. Therefore, glucose-induced vascular injury may stem directly from the hyperglycemic intrauterine environment of GDM pregnancy, as evinced by studies showing endothelial activation and inflammation at birth or in childhood in offspring born to GDM mothers. This review discusses potential mechanisms by which intrauterine hyperglycemia programs dysfunction in the developing vasculature.

scholarly journals Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Cecilia Tufiño ◽  
Cleva Villanueva-López ◽  
Maximiliano Ibarra-Barajas ◽  
Ismael Bracho-Valdés ◽  
Rosa Amalia Bobadilla-Lugo
Keyword(s):  
Diabetes Mellitus ◽  
Angiotensin Ii ◽  
Gestational Diabetes ◽  
Protein Expression ◽  
Gestational Diabetes Mellitus ◽  
Early Stage ◽  
Compensatory Mechanism ◽  
Functional Changes ◽  
Cox 2 ◽  
Cox 1

Diabetic conditions increase vascular reactivity to angiotensin II in several studies but there are scarce reports on cardiovascular effects of hypercaloric diet (HD) induced gestational diabetes mellitus (GDM), so the objective of this work was to determine the effects of HD induced GDM on vascular responses. Angiotensin II as well as phenylephrine induced vascular contraction was tested in isolated aorta rings with and without endothelium from rats fed for 7 weeks (4 before and 3 weeks during pregnancy) with standard (SD) or hypercaloric (HD) diet. Also, protein expression of AT1R, AT2R, COX-1, COX-2, NOS-1, and NOS-3 and plasma glucose, insulin, and angiotensin II levels were measured. GDM impaired vasoconstrictor response(P<0.05versus SD) in intact (e+) but not in endothelium-free (e−) vessels. Losartan reduced GDM but not SD e− vasoconstriction(P<0.01versus SD). AT1R, AT2R, and COX-1 and COX-2 protein expression were significantly increased in GDM vessels(P<0.05versus SD). Results suggest an increased participation of endothelium vasodilator mediators, probably prostaglandins, as well as of AT2vasodilator receptors as a compensatory mechanism for vasoconstrictor changes generated by experimental GDM. Considering the short term of rat pregnancy findings can reflect early stage GDM adaptations.

scholarly journals Activity of Caprine CSN1S2 Protein Reducing the COX-2 and IL-17 Expression of Aorta Tissue in Type 2 Diabetes Mellitus Rat

2018 ◽  
Vol 50 (3) ◽  
pp. 332-345 ◽  
Author(s):  
Yoga Tribakti Rachmad ◽  
◽  
Titin Andri Wihastuti ◽  
Katsuhiro Miyajima ◽  
Fatchiyah Fatchiyah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cox 2

scholarly journals Opposing effects of IL-1β/COX-2/PGE2 pathway loop on islets in type 2 diabetes mellitus

2019 ◽  
Vol 66 (8) ◽  
pp. 691-699 ◽  
Author(s):  
Guanqiao Wang ◽  
Rui Liang ◽  
Tengli Liu ◽  
Le Wang ◽  
Jiaqi Zou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cox 2 ◽  
Opposing Effects

scholarly journals Phytol Reduces Oxidative Stress and Cyclooxygenase-2 Expression in Kidney of Diabetic Wistar Rats

2018 ◽  
Vol 04 ◽  
pp. 16
Author(s):  
Adeyomoye Olorunsola Israel ◽  
Adewoye Elsie Olufunke ◽  
◽  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Normal Control ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Kidney Tissue ◽  
Diabetic Rats ◽  
Cyclooxygenase 2 ◽  
Sod Activity ◽  
Cox 2

Diabetes mellitus is characterized by hyperglycemia, which induces oxidative stress and inflammation. The role of Phytol in oxidative stress and inflammation was investigated in diabetic rats. Fifteen Wistar rats were divided into five groups (n = 5). Groups 1, 2, and 3 served as normal control, diabetic untreated, and diabetic treated with 250 mg/kg Phytol, respectively. Rats were treated for 28 days with Phytol, and then blood samples were collected under sodium thiopental (30 mg/kg i.p) anesthesia for assay. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined using commercially available Randox kits. Cyclooxygenase-2 (COX-2) expressions in kidney samples were determined using immunostaining procedure. Statistical analysis was done using one-way analysis of variance and level of statistical significance taken at p < 0.05. Results showed a significant increase (p < 0.05) in CAT and GPx activities in diabetic treated with 250 mg/kg Phytol when compared with diabetic untreated with Phytol. SOD activity significantly decreased in diabetic untreated and diabetic treated with 250 mg/kg Phytol when compared with normal control. COX-2 was significantly expressed in diabetic untreated when compared with normal control and diabetic treated with 250 mg/kg Phytol. Oral administration of Phytol reduces oxidative stress damage and inflammation of kidney tissue caused by hyperglycemia in diabetes mellitus.

Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus

1998 ◽  
Vol 39 (5) ◽  
pp. 663-668 ◽  
Author(s):  
Harry N. Bawden ◽  
Aidan Stokes ◽  
Carol S. Camfield ◽  
Peter R. Camfield ◽  
Sonia Salisbury
Keyword(s):  
Diabetes Mellitus ◽  
Peer Relationship ◽  
Tourette’S Disorder ◽  
Relationship Problems ◽  
Tourette's Disorder

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Kaposis sarcoma and diabetes mellitus

1971 ◽  
Vol 104 (4) ◽  
pp. 442-444 ◽  
Author(s):  
R. Tankel
Keyword(s):  
Diabetes Mellitus
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