scholarly journals Nitroxide-radicals–modified gold nanorods for in vivo CT/MRI-guided photothermal cancer therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 7123-7134 ◽  
Author(s):  
Luyao Xia ◽  
Chao Zhang ◽  
Min Li ◽  
Kaiyu Wang ◽  
Yushan Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Nitroxide Radicals ◽  
Mri Guided

In-vivo ultrasound and photoacoustic image- guided photothermal cancer therapy using silica-coated gold nanorods

2014 ◽  
Vol 61 (5) ◽  
pp. 891-897 ◽  
Author(s):  
Seungsoo Kim ◽  
Yun-sheng Chen ◽  
Geoffrey P. Luke ◽  
Stanislav Y. Emelianov
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Image Guided

scholarly journals Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

RSC Advances ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 1600-1610 ◽  
Author(s):  
Kostiantyn Turcheniuk ◽  
Tetiana Dumych ◽  
Rostyslav Bilyy ◽  
Volodymyr Turcheniuk ◽  
Julie Bouckaert ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Cancer Therapy ◽  
Reduced Graphene Oxide ◽  
Photon Energy ◽  
Gold Nanorods ◽  
Core Shell ◽  
Efficient Conversion ◽  
Reduced Graphene

Gold nanorods (Au NRs) are known for their efficient conversion of photon energy into heat, resulting in hyperthermia and suppression of tumor growths in vitro and in vivo.

Multidentate Polyethylene Glycol Modified Gold Nanorods for in Vivo Near-Infrared Photothermal Cancer Therapy

2014 ◽  
Vol 6 (8) ◽  
pp. 5657-5668 ◽  
Author(s):  
Xiangsheng Liu ◽  
Nan Huang ◽  
Huan Li ◽  
Haibo Wang ◽  
Qiao Jin ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cancer Therapy ◽  
Gold Nanorods ◽  
Near Infrared

Gold nanorods with a noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy

2019 ◽  
Vol 55 (90) ◽  
pp. 13506-13509 ◽  
Author(s):  
Ludan Yue ◽  
Chen Sun ◽  
Qian Cheng ◽  
Yuanfu Ding ◽  
Jianwen Wei ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cancer Therapy ◽  
Gold Nanorods ◽  
Au Nanorods ◽  
Image Guided

Cucurbit[7]uril functionalized Au nanorods allowed noncovalently tailorable surface modification for image-guided, targeted chemo-photothermal cancer therapy in vitro and in vivo.

In-vivo ultrasound and photoacoustic image- guided photothermal cancer therapy using silica-coated gold nanorods

2014 ◽  
Vol 61 (5) ◽  
pp. 891-897 ◽  
Author(s):  
Seungsoo Kim ◽  
Yun-sheng Chen ◽  
Geoffrey P. Luke ◽  
Stanislav Y. Emelianov
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Image Guided

scholarly journals Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 838
Author(s):  
Katharina A. Sterenczak ◽  
Nadine Stache ◽  
Sebastian Bohn ◽  
Stephan Allgeier ◽  
Bernd Köhler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Laser Scanning Microscopy ◽  
Sensory Nerves ◽  
Confocal Laser ◽  
Corneal Nerves ◽  
Over Time

During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged non-invasively by confocal laser scanning microscopy (CLSM) on the cellular level. Thus, in vivo CLSM imaging of structures of the corneal subbasal nerve plexus (SNP) such as sensory nerves or dendritic cells (DCs) can be a powerful tool for the assessment of corneal complications during cancer treatment. During the present study, the SNP of a breast cancer patient was analyzed over time by using large-scale in vivo CLSM in the course of paclitaxel and trastuzumab therapy. The same corneal regions could be re-identified over time. While the subbasal nerve morphology did not alter significantly, a change in dendritic cell density and an additional local burst within the first 11 weeks of therapy was detected, indicating treatment-mediated corneal inflammatory processes. Ocular structures such as nerves and dendritic cells could represent useful biomarkers for the assessment of ocular adverse effects during cancer therapy and their management, leading to a better visual prognosis.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals The Role of Herbal Bioactive Components in Mitochondria Function and Cancer Therapy

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Fangfang Tao ◽  
Yanrong Zhang ◽  
Zhiqian Zhang
Keyword(s):  
Cancer Therapy ◽  
Cancer Cell ◽  
Apoptotic Cell ◽  
Redox Status ◽  
Cancer Therapies ◽  
Bioactive Components ◽  
Atp Production

Mitochondria are highly dynamic double-membrane organelles which play a well-recognized role in ATP production, calcium homeostasis, oxidation-reduction (redox) status, apoptotic cell death, and inflammation. Dysfunction of mitochondria has long been observed in a number of human diseases, including cancer. Targeting mitochondria metabolism in tumors as a cancer therapeutic strategy has attracted much attention for researchers in recent years due to the essential role of mitochondria in cancer cell growth, apoptosis, and progression. On the other hand, a series of studies have indicated that traditional medicinal herbs, including traditional Chinese medicines (TCM), exert their potential anticancer effects as an effective adjunct treatment for alleviating the systemic side effects of conventional cancer therapies, for reducing the risk of recurrence and cancer mortality and for improving the quality of patients’ life. An amazing feature of these structurally diverse bioactive components is that majority of them target mitochondria to provoke cancer cell-specific death program. The aim of this review is to summarize the in vitro and in vivo studies about the role of these herbs, especially their bioactive compounds in the modulation of the disturbed mitochondrial function for cancer therapy.

scholarly journals Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Songtao Zhang ◽  
Longhai Jin ◽  
Jianhua Liu ◽  
Yang Liu ◽  
Tianqi Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Synergistic Effect ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Photothermal Effect ◽  
Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

Gold Nanorods Stabilized by Biocompatible and Multifunctional Zwitterionic Copolymer for Synergistic Cancer Therapy

2017 ◽  
Vol 15 (1) ◽  
pp. 164-174 ◽  
Author(s):  
Phim-on Khunsuk ◽  
Supatta Chawalitpong ◽  
Pritsana Sawutdeechaikul ◽  
Tanapat Palaga ◽  
Voravee P. Hoven
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods
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