scholarly journals Mitochondria-targeted delivery of doxorubicin to enhance antitumor activity with HER-2 peptide-mediated multifunctional pH-sensitive DQAsomes

2018 ◽  
Vol Volume 13 ◽  
pp. 4209-4226 ◽  
Author(s):  
Menghao Shi ◽  
Jiulong Zhang ◽  
Xiaowei Li ◽  
Shuang Pan ◽  
Jie Li ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Targeted Delivery ◽  
Ph Sensitive ◽  
Her 2

scholarly journals In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles

Biomaterials ◽  
2013 ◽  
Vol 34 (11) ◽  
pp. 2758-2772 ◽  
Author(s):  
Daniele Rubert Nogueira ◽  
Lorena Tavano ◽  
Montserrat Mitjans ◽  
Lourdes Pérez ◽  
M. Rosa Infante ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Chitosan Nanoparticles ◽  
Ph Sensitive

scholarly journals Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1422 ◽  
Author(s):  
Marcinkowska ◽  
Stanczyk ◽  
Janaszewska ◽  
Gajek ◽  
Ksiezak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Pamam Dendrimer ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Action ◽  
Her 2 ◽  
The Impact ◽  
Dendrimer Conjugates

Taxanes are considered fundamental drugs in the treatment of breast cancer, but despite the similarities, docetaxel (doc) and paclitaxel (ptx) work differently. For this reason, it is interesting to identify mechanisms of antitumor activity of PAMAM dendrimer conjugates that carry docetaxel or paclitaxel and monoclonal antibody trastuzumab, specifically targeted to cells which overexpressed HER-2. For this purpose, the impact on the level of reactive oxygen species, the mitochondrial membrane potential, cell cycle distribution and the activity of caspases-3/7, -8 and -9 of PAMAM-doc-trastuzumab and PAMAM-ptx-trastuzumab conjugates was determined and compared with free docetaxel and paclitaxel toward HER-2-positive (SKBR-3) and negative (MCF-7) human breast cancer cell lines. Moreover, apoptosis and necrosis were studied using flow cytometry and confocal microscopy, respectively. Our studies show the complexity of the potential mechanism of cytotoxic action of PAMAM-drug-trastuzumab conjugates that should be sought as a resultant of oxidative stress, mitochondrial activation of the caspase cascade and the HER-2 receptor blockade.

pH-sensitive deoxycholic acid dimer for improving doxorubicin delivery and antitumor activity in vivso

2020 ◽  
Vol 196 ◽  
pp. 111319
Author(s):  
Jiaxi Xu ◽  
Qin Fang ◽  
Longshun Yang ◽  
Jialu Gao ◽  
Yanbing Xue ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Deoxycholic Acid ◽  
Ph Sensitive ◽  
Doxorubicin Delivery

Synthesis andin vitroassessment of novel water-soluble dextran-docetaxel conjugates as potential pH sensitive system for tumor-targeted delivery

2017 ◽  
Vol 134 (43) ◽  
pp. 45457 ◽  
Author(s):  
Elahehnaz Parhizkar ◽  
Saeid Daneshamouz ◽  
Soliman Mohammadi-Samani ◽  
Amirhossein Sakhteman ◽  
Golnaz Parhizkar ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Ph Sensitive ◽  
Water Soluble

Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation

2016 ◽  
Vol 55 (39) ◽  
pp. 12035-12039 ◽  
Author(s):  
Qing-Li He ◽  
Il Minn ◽  
Qiaoling Wang ◽  
Peng Xu ◽  
Sarah A. Head ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Targeted Delivery ◽  
Glucose Conjugation

Synthesis of a New pH-Sensitive Folate–Doxorubicin Conjugate and its Antitumor Activity In Vitro

2013 ◽  
Vol 102 (2) ◽  
pp. 530-540 ◽  
Author(s):  
Wei-Liang Ye ◽  
Zeng-Hui Teng ◽  
Dao-Zhou Liu ◽  
Han Cui ◽  
Miao Liu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ph Sensitive

scholarly journals Integrin-targeted delivery into cancer cells of a Pt(iv) pro-drug through conjugation to RGD-containing peptides

2015 ◽  
Vol 44 (1) ◽  
pp. 202-212 ◽  
Author(s):  
Anna Massaguer ◽  
Alejandro González-Cantó ◽  
Esther Escribano ◽  
Silvia Barrabés ◽  
Gerard Artigas ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Selective Accumulation

Conjugation of a Pt(iv) pro-drug derivative of picoplatin to a tetrameric RGD-containing peptide leads to selective accumulation and antitumor activity in cancer cells overexpressing αVβ3 and αVβ5 integrins.

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