scholarly journals Hierarchically aligned fibrin nanofiber hydrogel accelerated axonal regrowth and locomotor function recovery in rat spinal cord injury

2018 ◽  
Vol Volume 13 ◽  
pp. 2883-2895 ◽  
Author(s):  
Shenglian Yao ◽  
Shukui Yu ◽  
Zheng Cao ◽  
Yongdong Yang ◽  
Xing Yu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Spinal Cord ◽  
Locomotor Function ◽  
Axonal Regrowth ◽  
Function Recovery ◽  
Cord Injury

scholarly journals The impact of myelination on axon sparing and locomotor function recovery in spinal cord injury assessed using diffusion tensor imaging

2013 ◽  
Vol 26 (11) ◽  
pp. 1484-1495 ◽  
Author(s):  
Tsang-Wei Tu ◽  
Joong H. Kim ◽  
Feng Qin Yin ◽  
Lyn B. Jakeman ◽  
Sheng-Kwei Song
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury ◽  
The Impact

scholarly journals Retraction Note to: Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury

2017 ◽  
Vol 38 (4) ◽  
pp. 707-707
Author(s):  
Bing Wang ◽  
Chen Chen ◽  
Jing-Tao Zhang ◽  
Ruo-Xian Song ◽  
Xiu-Chun Yu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury

scholarly journals Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Qing Chen ◽  
Dong Xie ◽  
Qiuju Yao ◽  
Lili Yang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Experimental Studies ◽  
High Quality ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury

Background. Disorder of locomotor function is universal in patients with spinal cord injury (SCI) and has a severe impairment on their quality of life. Metformin, the first-line antidiabetic drug, has been used to improve locomotor function in SCI rats through antioxidative mechanisms recently. Methods. A search strategy was conducted from databases, including PubMed, Web of Science, MEDLINE, and Scopus database until April 2021. The methodological quality of the animal experimental studies was assessed according to the Systematic Review Centre for Laboratory animal Experimentation’s Risk of Bias tool. The weighted mean difference was calculated with the random-effects model. Results. Seven eligible studies on SCI and metformin were reviewed. The meta-analysis indicated that SCI rats receiving metformin therapy showed a significant locomotor function recovery. Limitations and no obvious publication bias were presented in the studies. Conclusion. Metformin can promote the recovery of the locomotor function of SCI rats. However, the use of this meta-analysis was influenced due to the not high quality of studies. Consequently, more high-quality studies are necessary for preclinical studies of SCI in the future.

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