scholarly journals Multifunctional organic–inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery

2017 ◽  
Vol Volume 12 ◽  
pp. 1607-1620 ◽  
Author(s):  
Huibo Chi ◽  
Yan Gu ◽  
Tingting Xu ◽  
Feng Cao
Keyword(s):  
Drug Delivery ◽  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Ocular Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Chitosan Derivative ◽  
Uptake Mechanism ◽  
Inorganic Hybrid ◽  
Double Hydroxide ◽  
Cellular Uptake Mechanism

CELLULAR UPTAKE BEHAVIOR OF FLUORESCEIN: INTERCALATED LAYERED DOUBLE HYDROXIDE

2012 ◽  
Vol 05 (02) ◽  
pp. 1260003 ◽  
Author(s):  
MIYUKI TANAKA ◽  
SUMIO AISAWA ◽  
HIDETOSHI HIRAHARA ◽  
EIICHI NARITA ◽  
SHU YIN ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrothermal Treatment ◽  
Layered Double Hydroxide ◽  
Mammalian Cell ◽  
Cellular Uptake ◽  
L929 Cell ◽  
Low Cytotoxicity ◽  
High Fluorescence ◽  
Double Hydroxide

In order to define the ability of layered double hydroxide (LDH) as materials for drug delivery, fluorescein (Fluo) anion intercalated LDH (Fluo/LDH) was synthesized by hydrothermal treatment and observed the cellular uptake of the Fluo/LDH for mammalian cell (L929). The synthesized Fluo/LDH showed a LDH structure, high fluorescence and low cytotoxicity. According to the fluorescence, confocal and TEM images of cells, the Fluo/LDH seemed to be internalized into the L929 cell by cellular endocytosis and dissolved inside the cell to exhibit the fluorescence of cellular cytoplasm.

Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake

2015 ◽  
Vol 3 (16) ◽  
pp. 3331-3339 ◽  
Author(s):  
Zi Gu ◽  
Huali Zuo ◽  
Li Li ◽  
Aihua Wu ◽  
Zhi Ping Xu
Keyword(s):  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
New Strategy ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

We introduced a new strategy of albumin pre-coating to effectively stabilise layered double hydroxide (LDH) nanoparticles for biomedical applications.

Cellular uptake and gene delivery using layered double hydroxide nanoparticles

2013 ◽  
Vol 1 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Shuangde Li ◽  
Jinghuan Li ◽  
Chengle J. Wang ◽  
Qiang Wang ◽  
M. Zameel Cader ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

scholarly journals The Impact of Magnesium–Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent

2019 ◽  
Vol 20 (15) ◽  
pp. 3764 ◽  
Author(s):  
Mona Ebadi ◽  
Kalaivani Buskaran ◽  
Bullo Saifullah ◽  
Sharida Fakurazi ◽  
Mohd Zobir Hussein
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
The Body ◽  
Normal Fibroblast ◽  
Cellular Environment ◽  
Double Hydroxide ◽  
The Impact

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanoparticles was supported by various physico-chemical analyses. In addition, the drug content, kinetics, and mechanism of drug release also were studied. 5-fluorouracil (5FU) was found to be released in a controlled manner from the nanoparticles at pH = 4.8 (representing the cancerous cellular environment) and pH = 7.4 (representing the blood environment), governed by pseudo-second-order kinetics. The cytotoxicity study revealed that the anticancer delivery system of FPVA-FU-MLDH nanoparticles showed much better anticancer activity than the free drug, 5FU, against liver cancer and HepG2 cells, and at the same time, it was found to be less toxic to the normal fibroblast 3T3 cells.

CaAl-layered double hydroxide as a drug delivery system: effects on solubility and toxicity of the antiretroviral efavirenz

2016 ◽  
Vol 85 (3-4) ◽  
pp. 281-288 ◽  
Author(s):  
Danilo Augusto Ferreira Fontes ◽  
Magaly Andreza Marques de Lyra ◽  
Jeyce Kelle Ferreira de Andrade ◽  
Giovanna Christinne Rocha de Medeiros Schver ◽  
Larissa Araújo Rolim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Double Hydroxide
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