scholarly journals Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model

2017 ◽  
Vol Volume 12 ◽  
pp. 1385-1399 ◽  
Author(s):  
WG Singleton ◽  
AM Collins ◽  
AS Bienemann ◽  
CL Killick-Cole ◽  
HR Haynes ◽  
...  
Keyword(s):  
Convection Enhanced Delivery ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Glioma Model

scholarly journals PCM-17INTRATUMOURAL CONVECTION ENHANCED DELIVERY OF LBH589 (PANOBINOSTAT) LOADED PLURONIC-P407 NANO-MICELLES IS ASSOCIATED WITH ENHANCED SURVIVAL AND ANTI-TUMOUR RESPONSE IN THE ORTHOTOPIC F98/FISCHER 344 RAT GLIOMA MODEL

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii142.4-iii143
Author(s):  
William G.B. Singleton ◽  
Alison S. Bienemann ◽  
Clare L. Killick-Cole ◽  
Andrew M. Collins ◽  
Harry R. Haynes ◽  
...  
Keyword(s):  
Tumour Response ◽  
Convection Enhanced Delivery ◽  
Rat Glioma ◽  
Fischer 344 ◽  
Fischer 344 Rat ◽  
Glioma Model

scholarly journals OKN-007 decreases free radical levels in a preclinical F98 rat glioma model

2015 ◽  
Vol 87 ◽  
pp. 157-168 ◽  
Author(s):  
Patricia Coutinho de Souza ◽  
Nataliya Smith ◽  
Oluwatomisin Atolagbe ◽  
Jadith Ziegler ◽  
Charity Njoku ◽  
...  
Keyword(s):  
Free Radical ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Glioma Model

Utility of the F98 Rat Glioma Model for Photodynamic Therapy

2007 ◽  
Vol 26 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Steen J. Madsen ◽  
Khishigzaya Kharkhuu ◽  
Henry Hirschberg
Keyword(s):  
Photodynamic Therapy ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Glioma Model

scholarly journals P11.40 Development of an implantable multifunctional biodevice (GlioGel) in the treatment of recurrent glioblastoma

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii52-iii52
Author(s):  
L Déry ◽  
G Charest ◽  
M Akbari ◽  
D Fortin
Keyword(s):  
Tumor Cells ◽  
Median Survival ◽  
Complete Removal ◽  
Recurrent Glioblastoma ◽  
Control Group ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Glioma Model

Abstract BACKGROUND Glioblastoma (GBM) is a devastating disease with a median survival of 14–16 months. This poor prognosis can be explained by 3 factors. First, the infiltrative nature of the disease prohibits a complete removal of the tumor. Second, some of the tumor cells are brain tumor stem cells, which are highly migratory and highly resistant to treatments. Finally, the presence of the blood-brain barrier prohibits entry of therapeutics. This situation implies that new treatment approaches must be directed toward the infiltrated brain surrounding the resection cavity. To bypass this problem and improve the potency of adjuvant treatment, we have designed a new “GlioGel-device” that will have the ability to: 1- attract the migrating tumor cells into or nearby the device, and 2- subsequently deliver chemotherapy to the locally pooled tumor cells and 3- irradiate these cells with radioisotopes embedded in the GlioGel. MATERIAL AND METHODS In vitro proof of principle of chemoattraction was investigated by agarose drops method releasing chemokines molecules (CCL2, CCL11, CXCL10) with F98 and U87MG GBM cells. In vivo experiments evaluated the efficiency of chemokines and doxorubicin released by the implanted GlioGel on the tumor behaviour in our Fischer-F98 rat glioma model. An histology of tumour behaviour exposed to chemokines and survival of GBM rats treated with doxorubicin were analysed. RESULTS In vitro preliminary results for chemoattraction assays show that up to 2 times more cells invade the gel when it releases chemoattractant compared to PBS. The In vivo chemotherapy experiments with a fast, medium and slow release of doxorubicin from the GlioGel show that a local dose that represent a 1300-fold smaller dose than a normal intravenous systemic dose gave a significant reduction in tumour growth (median survival) compared to a control group. We investigated the effect provided by the GlioGel impregnated with chemokines on tumor cells migration, after implantation in the Fischer-F98 rat glioma model. CONCLUSION This preliminary study shows the ability of GlioGel releasing chemokines and doxorubicin to respectively attract and kill orthotopic glioblastoma cells. These encouraging results will be completed with a combination of short-range (high LET) radiation by embedded radioisotope into the GlioGel aiming for synergistic combination to eradicate as much tumour cells as possible, while limiting systemic side effects.

scholarly journals OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model

2015 ◽  
Vol 42 (6) ◽  
pp. 1582-1591 ◽  
Author(s):  
Patricia Coutinho de Souza ◽  
Krithika Balasubramanian ◽  
Charity Njoku ◽  
Natalyia Smith ◽  
David L. Gillespie ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Tumor Necrosis ◽  
Tumor Cell Proliferation ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Glioma Model

Radiation therapy combined with intracerebral convection-enhanced delivery of cisplatin or carboplatin for treatment of the F98 rat glioma

2020 ◽  
Vol 149 (2) ◽  
pp. 193-208
Author(s):  
Hélène Elleaume ◽  
Rolf F. Barth ◽  
Julia Rousseau ◽  
Laure Bobyk ◽  
Jacques Balosso ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Convection Enhanced Delivery ◽  
Rat Glioma ◽  
F98 Rat Glioma

Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model

2005 ◽  
Vol 63 (1) ◽  
pp. 247-252 ◽  
Author(s):  
Tomoko Ozawa ◽  
Javed Afzal ◽  
Kathleen R. Lamborn ◽  
Andrew W. Bollen ◽  
William F. Bauer ◽  
...  
Keyword(s):  
Convection Enhanced Delivery ◽  
Rat Glioma ◽  
Glioma Model

scholarly journals Cluster versus ROI analysis to assess combined antiangiogenic therapy and radiotherapy in the F98 rat-glioma model

2018 ◽  
Vol 31 (8) ◽  
pp. e3933 ◽  
Author(s):  
Nicolas Coquery ◽  
Raphael Serduc ◽  
Chantal Rémy ◽  
Emmanuel Luc Barbier ◽  
Benjamin Lemasson
Keyword(s):  
Antiangiogenic Therapy ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Glioma Model
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