scholarly journals Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma

2016 ◽  
Vol Volume 11 ◽  
pp. 4373-4380 ◽  
Author(s):  
ZiLing Sun ◽  
Hui Li ◽  
Jian Tian ◽  
Anqing Wu ◽  
Jiamin Wang ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Silk Fibroin ◽  
Silk Fibroin Nanoparticles ◽  
Self Assembled

scholarly journals Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis

2021 ◽  
pp. 120935
Author(s):  
Patricia Diez-Echave ◽  
Antonio Jesús Ruiz-Malagón ◽  
José Alberto Molina-Tijeras ◽  
Laura Hidalgo-García ◽  
Teresa Vezza ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Silk Fibroin Nanoparticles ◽  
Immunomodulatory Properties

scholarly journals Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1626-1636
Author(s):  
Afrasim Moin ◽  
Shahid Ud Din Wani ◽  
Riyaz Ali Osmani ◽  
Amr S. Abu Lila ◽  
El-Sayed Khafagy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silk Fibroin ◽  
Toxicity Assessment ◽  
Cellular Toxicity ◽  
Silk Fibroin Nanoparticles

Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy

2017 ◽  
Vol 9 (37) ◽  
pp. 31600-31611 ◽  
Author(s):  
Fatemeh Mottaghitalab ◽  
Melika Kiani ◽  
Mehdi Farokhi ◽  
Subhas C. Kundu ◽  
Rui L. Reis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Silk Fibroin ◽  
Delivery System ◽  
Targeted Delivery ◽  
Silk Fibroin Nanoparticles ◽  
Lung Cancer Therapy ◽  
Targeted Delivery System

Bioconjugation of Neutral Protease on Silk Fibroin Nanoparticles and Application in the Controllable Hydrolysis of Sericin

2011 ◽  
Vol 59 (18) ◽  
pp. 10298-10302 ◽  
Author(s):  
Lin Zhu ◽  
Ren-Ping Hu ◽  
Hai-Yan Wang ◽  
Yuan-Jing Wang ◽  
Yu-Qing Zhang
Keyword(s):  
Silk Fibroin ◽  
Neutral Protease ◽  
Silk Fibroin Nanoparticles ◽  
Hydrolysis Of

Nucleation of hydroxyapatite crystals by self-assembled Bombyx mori silk fibroin

2013 ◽  
Vol 51 (9) ◽  
pp. 742-748 ◽  
Author(s):  
Mingying Yang ◽  
Wen He ◽  
Yajun Shuai ◽  
Sijia Min ◽  
Liangjun Zhu
Keyword(s):  
Bombyx Mori ◽  
Silk Fibroin ◽  
Bombyx Mori Silk ◽  
Self Assembled ◽  
Hydroxyapatite Crystals

scholarly journals Silk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 364-375 ◽  
Author(s):  
He-Lin Xu ◽  
De-Li ZhuGe ◽  
Pian-Pian Chen ◽  
Meng-Qi Tong ◽  
Meng-Ting Lin ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Silk Fibroin ◽  
Thermal Therapy ◽  
Silk Fibroin Nanoparticles

scholarly journals Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 718 ◽  
Author(s):  
Marta G. Fuster ◽  
Guzmán Carissimi ◽  
Mercedes G. Montalbán ◽  
Gloria Víllora
Keyword(s):  
Silk Fibroin ◽  
Drug Loading ◽  
Drug Release Profile ◽  
Solubility In Water ◽  
Diphenyltetrazolium Bromide ◽  
Wide Range ◽  
Silk Fibroin Nanoparticles ◽  
Ea.Hy926 Cells ◽  
Cytotoxicity Effects

Naringenin (NAR), a flavonoid present in a variety of fruits, vegetables and herbs, exhibits a wide range of pharmacological effects, including anticancer activity. Nevertheless, its application in cancer therapy is limited due to its low bioavailability at the tumour site because of its poor solubility in water and slow dissolution rate. To improve the therapeutic efficacy of NAR, emergent research is looking into using nanocarriers. Silk fibroin (SF), from the Bombyx mori silkworm, is a biocompatible and biodegradable polymer with excellent mechanical properties and an amphiphilic chemistry that make it a promising candidate as a controlled release drug system. The aim of this work is to synthesize naringenin-loaded silk fibroin nanoparticles (NAR-SFNs) by dissolving the SF in the ionic liquid 1-ethyl-3-methylimidazolium acetate, using high-power ultrasounds and rapid desolvation in methanol followed by the adsorption of NAR. The NAR-SFNs were characterized by dynamic light scattering, Fourier transform infrared spectroscopy and thermogravimetric analysis. The drug loading content and encapsulation efficiency were calculated. The drug release profile best fitted a first order equation. The cytotoxicity effects of free NAR, bare silk fibroin nanoparticles (SFNs) and NAR-SFNs were assessed on HeLa and EA.hy926 cells via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results demonstrated the higher in vitro anticancer potential of synthesized NAR-SFNs than that of free NAR in HeLa cancer cells.

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