scholarly journals In vivo targeted gene delivery to peripheral neurons mediated by neurotropic poly(ethylene imine)-based nanoparticles

2016 ◽  
pp. 2675
Author(s):  
Ana Paula Pego ◽  
Catia Lopes ◽  
Hugo Oliveira ◽  
Ines Estevao ◽  
Liliana Pires
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
Targeted Gene Delivery ◽  
Peripheral Neurons ◽  
Poly Ethylene

scholarly journals In vivo targeted gene delivery to peripheral neurons mediated by neurotropic poly(ethylene imine)-based nanoparticles [Corrigendum]

2017 ◽  
Vol Volume 12 ◽  
pp. 5631-5632
Author(s):  
Cátia Lopes ◽  
Hugo Oliveira ◽  
Inês Estevão ◽  
Liliana Pires ◽  
Ana Paula Pêgo
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
Targeted Gene Delivery ◽  
Peripheral Neurons ◽  
Poly Ethylene

Biocompatibility and Efficacy of Oligomaltose-Grafted Poly(ethylene imine)s (OM-PEIs) for in Vivo Gene Delivery

2013 ◽  
Vol 10 (12) ◽  
pp. 4666-4675 ◽  
Author(s):  
Daniela Gutsch ◽  
Dietmar Appelhans ◽  
Sabrina Höbel ◽  
Brigitte Voit ◽  
Achim Aigner
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
In Vivo Gene Delivery ◽  
Poly Ethylene

Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c

2010 ◽  
Vol 143 (3) ◽  
pp. 350-358 ◽  
Author(s):  
Hugo Oliveira ◽  
Ramon Fernandez ◽  
Liliana R. Pires ◽  
M. Cristina L. Martins ◽  
Sérgio Simões ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tetanus Toxin ◽  
Ethylene Imine ◽  
Targeted Gene Delivery ◽  
Self Assembled ◽  
Poly Ethylene

scholarly journals Phase I/II and Phase II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Chemotherapy-resistant Sarcoma and Osteosarcoma

2009 ◽  
Vol 17 (9) ◽  
pp. 1651-1657 ◽  
Author(s):  
Sant P Chawla ◽  
Victoria S Chua ◽  
Lita Fernandez ◽  
Doris Quon ◽  
Andreh Saralou ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Phase I ◽  
Phase Ii ◽  
Targeted Gene Delivery ◽  
Phase Ii Studies

Integrin ανβ3Targeted Gene Delivery Using RGD Peptidomimetic Conjugates with Copolymers of PEGylated Poly(ethylene imine)

2009 ◽  
Vol 20 (6) ◽  
pp. 1270-1280 ◽  
Author(s):  
Olivia M. Merkel ◽  
Oliver Germershaus ◽  
Carol K. Wada ◽  
Peter J. Tarcha ◽  
Thomas Merdan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
Poly Ethylene

scholarly journals A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles

2020 ◽  
Vol 6 (31) ◽  
pp. eabc2148
Author(s):  
Yuting Wen ◽  
Hongzhen Bai ◽  
Jingling Zhu ◽  
Xia Song ◽  
Guping Tang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Targeted Delivery ◽  
Tumor Therapy ◽  
Sirna Delivery ◽  
Targeted Gene Delivery ◽  
Delivery Vehicles ◽  
Molecular Architectures ◽  
Host Polymer

It requires multistep synthesis and conjugation processes to incorporate multifunctionalities into a polyplex gene vehicle to overcome numerous hurdles during gene delivery. Here, we describe a supramolecular platform to precisely control, screen, and optimize molecular architectures of siRNA targeted delivery vehicles, which is based on rationally designed host-guest complexation between a β-cyclodextrin–based cationic host polymer and a library of guest polymers with various PEG shape and size, and various density of ligands. The host polymer is responsible to load/unload siRNA, while the guest polymer is responsible to shield the vehicles from nonspecific cellular uptake, to prolong their circulation time, and to target tumor cells. A series of precisely controlled molecular architectures through a simple assembly process allow for a rapid optimization of siRNA delivery vehicles in vitro and in vivo for therapeutic siRNA-Bcl2 delivery and tumor therapy, indicating the platform is a powerful screening tool for targeted gene delivery vehicles.

Alkylimidazolium End-Modified Poly(ethylene glycol) To Form the Mono-ion Complex with Plasmid DNA for in Vivo Gene Delivery

2014 ◽  
Vol 15 (3) ◽  
pp. 997-1001 ◽  
Author(s):  
Shoichiro Asayama ◽  
Atsushi Nohara ◽  
Yoichi Negishi ◽  
Hiroyoshi Kawakami
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Plasmid Dna ◽  
Poly Ethylene Glycol ◽  
In Vivo Gene Delivery ◽  
Poly Ethylene

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

2007 ◽  
Vol 342-343 ◽  
pp. 449-452 ◽  
Author(s):  
Tae Hee Kim ◽  
Hua Jin ◽  
Hyun Woo Kim ◽  
Myung Haing Cho ◽  
Jae Woon Nah ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery System ◽  
Targeted Gene Delivery ◽  
Cell Specificity ◽  
Selective Delivery

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

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