scholarly journals An infant with poor weight gain and hypochloremic metabolic alkalosis: a case report

2014 ◽  
pp. 389 ◽  
Author(s):  
Ahmed Alhammadi ◽  
Mohamed Khalifa ◽  
Lulwa Alnaimi
Keyword(s):  
Case Report ◽  
Weight Gain ◽  
Metabolic Alkalosis ◽  
Poor Weight Gain

Palatal Burn Due to Bottle Warming in a Microwave Oven

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 382-384
Author(s):  
ROBERTA A. HIBBARD ◽  
RONALD BLEVINS
Keyword(s):  
Case Report ◽  
Weight Gain ◽  
Birth Weight ◽  
Cesarean Section ◽  
Foreign Bodies ◽  
Microwave Oven ◽  
Cephalopelvic Disproportion ◽  
Infant Girl ◽  
Poor Weight Gain

Infections, tumors, nutshells, and foreign bodies may all be seen clinically as unusual lesions of the palate in children.1,2 We describe the case of an infant girl who had a palatal lesion, eventually determined to be secondary to a scald burn. We emphasize this case because the eventual diagnosis was not considered until almost 2 months after the patient was first seen, at which time additional history was elicited. CASE REPORT C.P. was a 4-month-old girl referred to our hospital for evaluation and treatment of poor weight gain with a palatal lesion. She was delivered by cesarean section for cephalopelvic disproportion after an uncomplicated fullterm pregnancy; her birth weight was 3,820 g (90th percentile).

Triploidy: Case Report of a Live-born Male and an Ethical Dilemma

PEDIATRICS ◽  
1984 ◽  
Vol 74 (2) ◽  
pp. 296-299
Author(s):  
ROGER G. FAIX ◽  
MASON BARR ◽  
JOHN R. WATERSON
Keyword(s):  
Mechanical Ventilation ◽  
Case Report ◽  
Weight Gain ◽  
Ethical Issues ◽  
Present Report ◽  
Male Infant ◽  
First Trimester ◽  
Handicapped Children ◽  
Severely Handicapped ◽  
Poor Weight Gain

Triploidy (69 chromosomes) is found in as many as 12% of karyotyped spontaneous first trimester abortuses, but it is rare in live-born infants.1 The longest reported survival of an infant with complete triploidy is seven months.2 Multiple anomalies, poor weight gain, and neurodevelopmental arrest are characteristic of the few reported liveborn infants.2-5 The uniformly dismal outcome of these infants has been considered a contraindication for the use of extraordinary support, eg, mechanical ventilation, once the diagnosis is established. However, ethical issues concerning the treatment of such severely handicapped children are subjects of continuing controversy. The present report describes the course of a male infant with complete triploidy; his survival was artificially prolonged for four months in accordance with parental religious beliefs.

Metabolic Alkalosis Secondary to Baking Soda Treatment of a Diaper Rash

PEDIATRICS ◽  
1981 ◽  
Vol 67 (6) ◽  
pp. 820-822
Author(s):  
Jose Gonzalez ◽  
Ronald J. Hogg
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Sodium Bicarbonate ◽  
Complete Resolution ◽  
Metabolic Alkalosis ◽  
Acid Base ◽  
Prior Application ◽  
Acid Base Disturbance ◽  
Base Disturbance

A 4-month-old infant was seen with hypokalemic metabolic alkalosis that was associated with prior application of liberal amounts of sodium bicarbonate (baking soda) to a diaper rash. After exclusion of other etiologies of the infant's acid-base disturbance, a complete resolution occurred following discontinuation of the baking soda applications. This case report provides a reminder of the significant side effects that may result from the excessive use of a seemingly harmless household substance.

MO234LIFE THREATENING MALIGNANT HYPERCALCEMIA IN BREAST CANCER: CAN THE NEPHROLOGIST CHANGE THE PATIENT DESTINY?

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Matilde Pensabene ◽  
Claudia Von Arx ◽  
Sofia Giuliana ◽  
Filomena Calabrese ◽  
Paola Capodanno ◽  
...  
Keyword(s):  
Case Report ◽  
Cancer Patients ◽  
Metabolic Alkalosis ◽  
Neoadjuvant Treatment ◽  
Disease Stage ◽  
Humoral Factors ◽  
Dialysis Unit ◽  
Advanced Malignancy ◽  
Severe Hypercalcemia ◽  
Advanced Malignancies

Abstract Background Malignant hypercalcemia is a common complication in cancer patients and can be predictive of poor prognosis and advanced malignancy. Cancer-related mechanisms of hypercalcemia depends either on ectopic hypersecretion of humoral factors (PTH, PTH-like molecules, Vit D) by the tumoral mass, or on osteolysis due to bone invasion. In consideration of the high renal and cardiac impact of severe hypercalcemia, its prompt recognition and treatment can be lifesaving. AKI is frequently associated with malignant hypercalcemia and recognizes a multifactorial pathogenesis (direct renal vasoconstriction, volume depletion, tubule-interstitial damage, etc.). Substitutive renal treatment can be necessary, but not always viable in patients with poor physical performance and is a difficult choice in cancer patients with advanced malignancies. Case report We present the case of a 46 years old woman with an infiltrating non special type (NST) carcinoma of the right breast (luminal B, ER 70%, PgR 60%, Ki67 35%, HER2 1+). Unfortunately, she quickly progressed after a neoadjuvant treatment with Epirubicin/Cyclophosfamide (4 cycles) followed by Paclitaxel (10 cycles). A first line hormonal treatment (Palbociclib, Letrozole and LHRH analogous) was then started, but a further rapid disease progression was observed. A new biopsy showed a muted and more aggressive cancer phenotype (high grade triple negative carcinoma with no PDL1 expression). Due to a rapid worsening of general conditions with cognitive impairment, the patient was admitted to the Oncology department. Blood test showed severe hypercalcemia (corrected calcium: 23.26 mg/dl) and severe hypokalemic metabolic alkalosis (blood pH 7.57; HCO-3 32 mmol/l; K+ 2.6 mmol/l) associated to AKI (creatinine doubled to 1.42 mg/dl; eGFR 45 ml/min/1,73 mq). Alkaline phosphatase and Vitamin D were normal and iPTH was < 2 pg/ml. ECG showed a significant QTc prolongation to 550 msec. Imaging exams revealed lung metastasis, lung carcinomatous lymphangitis and bilateral pleural effusion, while Bone Scan showed a low caption limited to right ribs. Oncologists and Intensive Care Physicians referred to our Nephrology and Dialysis Unit proposing Hemodialysis support. In consideration of the preserved diuresis, the advanced disease stage and the unstable hemodynamics, our advice was instead for a conservative medical approach. An i.v. infusion of 4000 ml NaCl 0.9% + KCl 60 mEq/24h; a continuous i.v. infusion of Furosemide 5mg/h were started and maintained for several days, leading to a progressive and full renal function recovery (creatinine decreased to 0.7 mg/dl) and metabolic alkalosis correction. However, corrected calcium remained largely over target, being 16.3 mg/dl. Sodium bicarbonate 80 mEq, Zoledronic acid 4 mg and Desametasone 4mg/day were administered and at day 16 even calcium was in normal range. We realized that this was a favourable window for acting on the underlaying cause of malignant hypercalcemia, that likely was the aberrant secretion of non-dosable PTH-like molecule(s). Thus, we suggested the Oncologist to start chemotherapy, and they were allowed to treat the patient with Carboplatin/Gemcitabine. The patient was successfully treated with stabilization of normocalcemia and is still alive. Conclusion Malignant hypercalcemia is a life-threatening complication in advanced malignancies. Our case report highlights the key role of the nephrologist in treating a complex and fragile oncologic patient, achieving the full correction of several severe renal disorders, hemodialysis avoidance and survival improvement.

scholarly journals The Gut Microbiome Derived From Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice

Endocrinology ◽  
2019 ◽  
Vol 160 (10) ◽  
pp. 2441-2452 ◽  
Author(s):  
Tomokazu Hata ◽  
Noriyuki Miyata ◽  
Shu Takakura ◽  
Kazufumi Yoshihara ◽  
Yasunari Asano ◽  
...  
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Weight Gain ◽  
Food Intake ◽  
Brain Stem ◽  
Body Weight Gain ◽  
Field Tests ◽  
Compulsive Behavior ◽  
The Brain ◽  
Poor Weight Gain

Abstract Anorexia nervosa (AN) results in gut dysbiosis, but whether the dysbiosis contributes to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. To address this, germ-free mice were reconstituted with the microbiota of four patients with restricting-type AN (gAN mice) and four healthy control individuals (gHC mice). The effects of gut microbes on weight gain and behavioral characteristics were examined. Fecal microbial profiles in recipient gnotobiotic mice were clustered with those of the human donors. Compared with gHC mice, gAN mice showed a decrease in body weight gain, concomitant with reduced food intake. Food efficiency ratio (body weight gain/food intake) was also significantly lower in gAN mice than in gHC mice, suggesting that decreased appetite as well as the capacity to convert ingested food to unit of body substance may contribute to poor weight gain. Both anxiety-related behavior measured by open-field tests and compulsive behavior measured by a marble-burying test were increased only in gAN mice but not in gHC mice. Serotonin levels in the brain stem of gAN mice were lower than those in the brain stem of gHC mice. Moreover, the genus Bacteroides showed the highest correlation with the number of buried marbles among all genera identified. Administration of Bacteroides vulgatus reversed compulsive behavior but failed to exert any substantial effect on body weight. Collectively, these results indicate that AN-specific dysbiosis may contribute to both poor weight gain and mental disorders in patients with AN.

Low Birth Weight and Subsequent Poor Weight Gain

2014 ◽  
Vol 28 (4) ◽  
pp. 350-356 ◽  
Author(s):  
Jeannie Rodriguez ◽  
Marti Rice
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Poor Weight Gain
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