scholarly journals Usefulness of visual evaluation of the anterior thalamic radiation by diffusion tensor tractography for differentiating between Alzheimer’s disease and elderly major depressive disorder patients

2013 ◽  
pp. 189 ◽  
Author(s):  
Akira Niida ◽  
Kuniyoshi ◽  
Motomura ◽  
Uechi ◽  
Niida
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Diffusion Tensor ◽  
Diffusion Tensor Tractography ◽  
Major Depressive ◽  
Visual Evaluation ◽  
Anterior Thalamic Radiation

scholarly journals Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Ziwei Liu ◽  
Lijun Kang ◽  
Aixia Zhang ◽  
Chunxia Yang ◽  
Min Liu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Quality Indicators ◽  
Diffusion Tensor ◽  
Superior Longitudinal Fasciculus ◽  
Major Depressive ◽  
First Degree Relatives ◽  
Corticospinal Tracts ◽  
Anterior Thalamic Radiation

At present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2–3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD. The purpose of this study is to explore the etiology of MDD by DTI and further to explore the correlation between its clinical characteristics and the structural changes of white matter in the brain. The study included 27 first-episode, drug-naive patients with MDD, 16 first-degree relatives without MDD, and 28 healthy control subjects with no family history of MDD (HC). Results showed that the fractional anisotropy (FA) differences among the three groups were mainly in the left anterior thalamic radiation (LATR), right anterior thalamic radiation (RATR), left corticospinal tracts (LCST), forceps major (FMa), right inferior longitudinal fasciculus (RILF), and left superior longitudinal fasciculus (temporal) (LSLF(T)). Among the 6 sites, LCST, FMa, and LSLF(T) showed significant differences between MDD and First-degree relatives compared to HC. MDD patients had significant emotional symptoms, somatic symptoms, and cognitive impairment. FMa FA was significantly positively correlated with delayed memory score ( r = 0.43 , P = 0.031 ), and RILF FA was significantly negatively correlated with the FSS score ( r = − 0.42 , P = 0.028 ). These results revealed that the white matter characteristics of MDD-susceptible patients were LCST, FMa, and LSLF(T) lesions, all of which may be quality indicators of MDD.

scholarly journals Diffusion tensor imaging brain structural clustering patterns in major depressive disorder

2021 ◽  
Author(s):  
Dongrong Xu ◽  
Guojun Xu ◽  
Zhiyong Zhao ◽  
M. Elizabeth Sublette ◽  
Jeffrey M. Miller ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Diffusion Tensor Imaging ◽  
Depressive Disorder ◽  
Diffusion Tensor ◽  
Major Depressive ◽  
Structural Clustering ◽  
Clustering Patterns

scholarly journals Relationship between white matter integrity and serum cortisol levels in drug-naive patients with major depressive disorder: Diffusion tensor imaging study using tract-based spatial statistics

2016 ◽  
Vol 208 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Xiaodan Liu ◽  
Keita Watanabe ◽  
Shingo Kakeda ◽  
Reiji Yoshimura ◽  
Osamu Abe ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Diffusion Tensor ◽  
Serum Cortisol ◽  
White Matter Integrity ◽  
Uncinate Fasciculus ◽  
Major Depressive ◽  
Drug Naïve ◽  
Cortisol Levels ◽  
Anterior Thalamic Radiation

BackgroundHigher daytime cortisol levels because of a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). The elevated glucocorticoids inhibit the proliferation of the oligodendrocytes that are responsible for myelinating the axons of white matter fibre tracts.AimsTo evaluate the relationship between white matter integrity and serum cortisol levels during a first depressive episode in drug-naive patients with MDD (MDD group) using a tract-based spatial statistics (TBSS) method.MethodThe MDD group (n = 29) and a healthy control group (n = 47) underwent diffusion tensor imaging (DTI) scans and an analysis was conducted using TBSS. Morning blood samples were obtained from both groups for cortisol measurement.ResultsCompared with the controls, the MDD group had significantly reduced fractional anisotropy values (P<0.05, family-wise error (FWE)-corrected) in the inferior fronto-occipital fasciculus, uncinate fasciculus and anterior thalamic radiation. The fractional anisotropy values of the inferior fronto-occipital fasciculus, uncinate fasciculus and anterior thalamic radiation had significantly negative correlations with the serum cortisol levels in the MDD group (P<0.05, FWE-corrected).ConclusionsOur findings indicate that the elevated cortisol levels in the MDD group may injure the white matter integrity in the frontal–subcortical and frontal–limbic circuits.

White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder

2020 ◽  
pp. 1-9
Author(s):  
Susanne Meinert ◽  
Elisabeth J. Leehr ◽  
Dominik Grotegerd ◽  
Jonathan Repple ◽  
Katharina Förster ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Cross Sectional Study ◽  
Disease State ◽  
Major Depressive ◽  
Cross Sectional ◽  
Course Of Illness ◽  
The Right

Abstract Background Eighty percent of all patients suffering from major depressive disorder (MDD) relapse at least once in their lifetime. Thus, understanding the neurobiological underpinnings of the course of MDD is of utmost importance. A detrimental course of illness in MDD was most consistently associated with superior longitudinal fasciculus (SLF) fiber integrity. As similar associations were, however, found between SLF fiber integrity and acute symptomatology, this study attempts to disentangle associations attributed to current depression from long-term course of illness. Methods A total of 531 patients suffering from acute (N = 250) or remitted (N = 281) MDD from the FOR2107-cohort were analyzed in this cross-sectional study using tract-based spatial statistics for diffusion tensor imaging. First, the effects of disease state (acute v. remitted), current symptom severity (BDI-score) and course of illness (number of hospitalizations) on fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity were analyzed separately. Second, disease state and BDI-scores were analyzed in conjunction with the number of hospitalizations to disentangle their effects. Results Disease state (pFWE < 0.042) and number of hospitalizations (pFWE< 0.032) were associated with decreased FA and increased MD and RD in the bilateral SLF. A trend was found for the BDI-score (pFWE > 0.067). When analyzed simultaneously only the effect of course of illness remained significant (pFWE < 0.040) mapping to the right SLF. Conclusions Decreased FA and increased MD and RD values in the SLF are associated with more hospitalizations when controlling for current psychopathology. SLF fiber integrity could reflect cumulative illness burden at a neurobiological level and should be targeted in future longitudinal analyses.

scholarly journals Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder

2021 ◽  
Author(s):  
Haixia Zheng ◽  
◽  
Maurizio Bergamino ◽  
Bart N. Ford ◽  
Rayus Kuplicki ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Fractional Anisotropy ◽  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
Diffusion Tensor ◽  
Major Depressive ◽  
Replication Sample ◽  
Discovery Sample

AbstractMajor depressive disorder (MDD) is associated with reductions in white matter microstructural integrity as measured by fractional anisotropy (FA), an index derived from diffusion tensor imaging (DTI). The neurotropic herpesvirus, human cytomegalovirus (HCMV), is a major cause of white matter pathology in immunosuppressed populations but its relationship with FA has never been tested in MDD despite the presence of inflammation and weakened antiviral immunity in a subset of depressed patients. We tested the relationship between FA and HCMV infection in two independent samples consisting of 176 individuals with MDD and 44 healthy controls (HC) (Discovery sample) and 88 participants with MDD and 48 HCs (Replication sample). Equal numbers of HCMV positive (HCMV+) and HCMV negative (HCMV−) groups within each sample were balanced on ten different clinical/demographic variables using propensity score matching. Anti-HCMV IgG antibodies were measured using a solid-phase ELISA. In the Discovery sample, significantly lower FA was observed in the right inferior fronto-occipital fasciculus (IFOF) in HCMV+ participants with MDD compared to HCMV− participants with MDD (cluster size 1316 mm3; pFWE < 0.05, d = −0.58). This association was confirmed in the replication sample by extracting the mean FA from this exact cluster and applying the identical statistical model (p < 0.05, d = −0.45). There was no significant effect of diagnosis or interaction between diagnosis and HCMV in either sample. The effect of chronic HCMV infection on white matter integrity may—in at-risk individuals—contribute to the psychopathology of depression. These findings may provide a novel target of intervention for a subgroup of patients with MDD.

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