scholarly journals Epstein–Barr virus-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement

2012 ◽  
pp. 715 ◽  
Author(s):  
Makoto Saito ◽  
Irie ◽  
Tanaka ◽  
Matsuno ◽  
Morioka ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Involvement ◽  
Positive Lymph Node ◽  
Plasmablastic Lymphoma ◽  
Barr Virus ◽  
Node Involvement

Factors affecting nodal involvement in mucinous breast cancer.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 124-124
Author(s):  
Tracy Nguyen ◽  
Bryce Stash ◽  
Portia Siwawa ◽  
Subhasis Misra
Keyword(s):  
Lymph Node ◽  
Tumor Size ◽  
Statistical Significance ◽  
Mucinous Carcinoma ◽  
Lymph Node Involvement ◽  
Positive Lymph Node ◽  
Axillary Lymph ◽  
Node Involvement ◽  
Axillary Lymph Node Involvement ◽  
Mucinous Breast Carcinoma

124 Background: Mucinous carcinoma of the breast is a rare type of invasive ductal breast cancer that accounts for 2-5% of all primary breast cancers. Axillary lymph node involvement for mucinous breast carcinoma is rare and correlated with a poor prognosis. However, the relation of lymph node involvement to certain factors is unknown, hence the purpose of our study. Methods: Retrospective chart review of patients diagnosed with mucinous breast carcinoma from 2004 to 2014 from the local tumor registry. Variables include age, tumor size, lymph node metastasis, diagnosis type (pure/mixed), and hormone status of patients. Chi square and T-test was performed. Results: 45 female patients were included in the study with the age range of 35 to 97 years old. 39 patients were diagnosed with mixed mucinous carcinoma and 6 had pure mucinous carcinoma. 9 patients had positive axillary lymph node involvement. 78% of patients with positive lymph node had mixed mucinous carcinoma and 22% had pure mucinous carcinoma. There is no statistical significance (p > 0.05) between lymph node involvement and diagnosis type. Tumor size ranged from 4 to 120 mm, with a mean of 28 mm. 78% of patients with positive lymph node had a tumor size smaller than 60 mm. The other two had a tumor size of 65 mm. and 120 mm. There is no statistical significance (p > 0.05) in the proportion of people who are lymph node positive to tumor size less than 60 mm. Out of the 45 patients, 42 patients expressed ER receptors, 36 expressed PR receptors, and 12 expressed HER2 receptors. 89% of positive lymph node patients express ER hormone receptors, 78% expressed PR receptors, and 56% expressed HER2 receptors. No correlation between ER/PR status and lymph node involvement (p > 0.05) was found but there was a positive correlation between HER2 receptor status and lymph node involvement (p < 0.05). Conclusions: No significant difference between diagnosis type/tumor size in relation to lymph node involvement. Although there is a trend between small tumor size to positive lymph node, it is not significant enough. There is a significant relationship between HER2 positive receptors and lymph node involvement. This is suggestive that the biological nature of the tumor has a larger influence on lymph node involvement than the physical nature.

Survival for stage IB cervical cancer with positive lymph node involvement: a comparison of completed vs. abandoned radical hysterectomy

2008 ◽  
Vol 109 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Scott D. Richard ◽  
Thomas C. Krivak ◽  
Anthony Castleberry ◽  
Sushil Beriwal ◽  
Joseph L. Kelley ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Radical Hysterectomy ◽  
Lymph Node Involvement ◽  
Positive Lymph Node ◽  
Stage Ib ◽  
Node Involvement

scholarly journals The Clinical Significance of Preoperative Plasma Fibrinogen Levels and Platelet Count in Resectable Colon Cancer

2020 ◽  
Author(s):  
Berrin Papila Kundaktepe ◽  
Cigdem Papila
Keyword(s):  
Colon Cancer ◽  
Platelet Count ◽  
Lymph Node ◽  
Clinical Significance ◽  
Venous Invasion ◽  
Lymph Node Involvement ◽  
Positive Lymph Node ◽  
Plasma Fibrinogen ◽  
Node Involvement ◽  
The Relationship

Abstract Background and aims: There is still much unknown about the relationship between colon cancer and markers of hemostasis. İn these study, whether or not preoperative platelet (PLT) counts, plasma fibrinogen levels were associated with postoperative lymph node involvement and venous invasion was evaluated in patients of colon cancer.Methods: Eighty patients (mean age: 58.09 years, 37% females, 63% male) were retrospectively included in this study.Results: PLT and fibrinogen values in patients with lymph node and venous invasion negative colon cancer; were significantly lower than patients with positive lymph node (p<0.001, all of them) and venous invasion (p<0.001, all of them). A positive correlation was found between the venous invasion and lymphatic involvement with PLT count and plasma fibrinogen levels (r=0.640, p<0.001; r=0.810, p<0.001, respectively).Conclusion: It was concluded that preoperative PLT count and plasma fibrinogen levels may be useful marker for monitoring postoperative lymph node involvement and venous invasion in patients with colon cancer.

Clinicopathological Characteristics and Clinical Outcome in Egyptian Female Breast Cancer Patients With and Without BRCA1/2 Mutations

2020 ◽  
Vol 106 (1_suppl) ◽  
pp. 11-11
Author(s):  
SG AbdelHamid ◽  
HO El-Mesallamy ◽  
HM AbdelAziz ◽  
ARN Zekri
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Clinicopathological Characteristics ◽  
Positive Lymph Node ◽  
Breast Cancers ◽  
Deleterious Mutations ◽  
Brca Mutations ◽  
Node Involvement ◽  
History Of

Introduction: Germline mutations in BRCA1 and BRCA2 genes confer high risk of developing breast cancer. We sought to examine whether the clinicopathological characteristics and the clinical outcome differ in patients with and without BRCA mutations. Patients and Methods: A series of 103 Egyptian female patients were recruited from Breast Cancer Unit, Clinical Oncology Department, Ain Shams University, Egypt. The enrolled patients, unselected for age of onset or family history, were tested for BRCA1/2 mutations using HRM analysis and direct sequencing. The clinical and pathological features of the patients were retrospectively assessed and comparisons were made using Chi-square. Disease free survival (DFS) was estimated by Kaplan–Meier method and compared in the two groups with log-rank. Results: The overall rate of BRCA1/2 mutations was 44%. Novel deleterious mutations were detected and submitted to NCBI Clinvar database. Deleterious mutations were identified in 29 cases and unclassified variants in 32 cases, 15 of which had a co-occuring deleterious mutation. Patients with BRCA mutations tended to have early onset breast cancer compared to non-carriers ( P=0.002), more often premenopausal ( P=0.006), with a familial history of breast cancer as well as other cancers ( P=0.005). BRCA-related breast cancers were more likely to have T3-T4 stage than wild type (41% versus 28%, P=0.02), positive lymph node involvement (78 versus 53%, P=0.007) and develop bilateral breast cancers (24% versus 9%, P =0.007). The incidence of ER negative and PR negative tumors was higher in BRCA carriers, but not statistically significant ( P=0.17 and 0.15, respectively). No difference in HER-2/ neu status was observed ( P=0.25). Early age at onset, positive lymph node involvement, family history of any cancer were independent predictive factors for occurrence of BRCA1/2 mutations. The median follow-up time for the cohort was 5.53 years. Patients with BRCA mutations had poorer 5-year DFS compared to non-carriers (47.7% versus 67.4%, P=0.041); but Cox regression analysis failed to demonstrate a significant independent influence of BRCA mutation status on DFS. Conclusion: This study shows that BRCA-related breast cancers in the Egyptian population have distinctive clinical and tumor features as well as outcome. This data has important health implications for guiding cancer control policies.

Evaluation of pre-operative clinical finding and per-operative assessment of carcinoma stomach in tertiary settings of Bangladesh

2020 ◽  
Vol 22 (1) ◽  
pp. 43-46
Author(s):  
Mst Jesmen Nahar ◽  
Md Mahiuddin Matubber ◽  
Md Mahbubur Rahman ◽  
Md Mahbubur Rahman ◽  
Syed Muhammad Baqul Billah ◽  
...  
Keyword(s):  
Lymph Node ◽  
Clinical Picture ◽  
Preoperative Evaluation ◽  
Lymph Node Involvement ◽  
Lesion Detection ◽  
Clinical Feature ◽  
P Value ◽  
Operative Finding ◽  
Node Involvement ◽  
Carcinoma Stomach

Background: Carcinoma stomach, a major killer cancer all over the world, is still presenting late in developing countries due to delay in early diagnosis, lack of awareness, infrastructure etc. Objectives: To establish the importance of preoperative evaluation on operability of carcinoma stomach. Methods: Sixty clinically and histopathologically diagnosed ca stomach cases who underwent surgery in department of Bangabandhu Sheikh Mujib Medical University, Dhaka, and Dhaka Medical College Hospital, Dhaka in 2011 were assessed with clinical picture, investigations, preoperative evaluation and peroperative findings were recorded. Z test for proportion was used to assess clinical decision predictability with a p value of :s;0.05 as significant. Results: Male (73.33%) predominant with 2.75:1 male:female ratio was observed. Mobility, fixity and abdominal lymphadenopathy were not well detected through clinical assessment (p=0.001) while ascites, metastasis and Shelf of Slummer were similar in both clinical and operative finding. The endoscopy of upper GIT finding gave a unique picture as the findings were almost same as were found during operation. USG detected a lesser proportion of the clinical condition compared to peroperative condition whereas CT performed better than the USG except for the lesion detection. Though Computed Tomography (CT) detected higher percentage of lesion, metastasis, ascites and lymph node involvement compared to ultrasonogram (USG), it was significantly higher only for lesion detection (p=0.002) and lymph node involvement (p=<0.001). In the similar manner USG assessment of lesion detection (p=<0.001) and lymph node involvement (p=0.003) was significantly low compared to operative finding. When we looked between CT and operative finding only lesion detection was significantly low (p=0.01) indicating CT to be most effective predictor of clinical picture for operative decision. Preoperative plan were mostly not in accordance with peroperative decision except for total gastrectomy. Conclusion: The study indicates weakness in clinical detection and pre-operative plan compared to per-operative finding. Hence combination of clinical feature and investigation tools especially endoscopy of upper GIT combined with CT is recommended to predict a better operative decision. Journal of Surgical Sciences (2018) Vol. 22 (1): 43-46

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