scholarly journals Nomogram to Predict the Occurrence and Prognosis of Distant Metastasis in T1N0 Colon Cancer: A SEER Data-Based Study

2021 ◽  
Vol Volume 14 ◽  
pp. 9131-9143
Author(s):  
Yunxiao Liu ◽  
Hao Zhang ◽  
Mingyu Zheng ◽  
Chunlin Wang ◽  
Zhiqiao Hu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Distant Metastasis ◽  
Seer Data

scholarly journals Nomogram to Predict the Occurrence and Prognosis of Distant Metastasis in T1n0 Colon Cancer: A Seer Data-Based Study

2021 ◽  
Author(s):  
Yunxiao Liu ◽  
Hao Zhang ◽  
Mingyu Zheng ◽  
Chunlin Wang ◽  
Zhiqiao Hu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Distant Metastasis ◽  
Roc Curves ◽  
Population Based ◽  
Good Discrimination ◽  
Factors Associated ◽  
Seer Data ◽  
Size Grade ◽  
Independent Risk Factors ◽  
Development And Validation

Abstract Distant metastasis (DM) is relatively rare in T1 colon cancer (CC) patients, especially in those with negative lymph node metastasis. The aim of this study was to explore the main clinical factors and build nomogram for predicting the occurrence and prognosis of DM in T1N0 colon cancer patients. Patients with T1N0 stage colon cancer were collected from the Surveillance, Epidemiology, and End Result (SEER) database. All patients were divided into development and validation cohorts with the 3:1 ratio. A total of 6770 patients were enrolled in this study, including 428 patients (6.3%) with DM. Age, size, grade, CEA were independent risk factors associated with DM. Age, grade, CEA, surgery and chemotherapy were independent prognostic factors for CSS. Nomogram were applied and C-index, calibration curves, ROC curves and DCA curves proved good discrimination, calibration and clinical practicability of the nomogram in predicting the occurrence and prognosis of DM in T1N0 colon cancer patients. The population-based nomogram could help clinicians predict the occurrence and prognosis of DM in T1N0 CC patients and provide a reference to perform appropriate metastatic screening plans and rational therapeutic options for the special population.

scholarly journals Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Shiue-Wei Lai ◽  
Ming-Yao Chen ◽  
Oluwaseun Adebayo Bamodu ◽  
Ming-Shou Hsieh ◽  
Ting-Yi Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cell Lines ◽  
Distant Metastasis ◽  
Cancer Metastasis ◽  
Lovo Cell ◽  
Promoting Effect ◽  
Colon Cancer Metastasis

Background. Treating advanced colon cancer remains challenging in clinical settings because of the development of drug resistance and distant metastasis. Mechanisms underlying the metastasis of colon cancer are complex and unclear. Methods. Computational analysis was performed to determine genes associated with the exosomal long noncoding (lncRNA) plasmacytoma variant translocation 1 (PVT1)/vascular endothelial growth factor A (VEGFA) axis in patients with colon cancer. The biological importance of the exosomal lncRNA PVT1/VEGFA axis was examined in vitro by using HCT116 and LoVo cell lines and in vivo by using a patient-derived xenograft (PDX) mouse model through knockdown (by silencing of PVT1) and overexpression (by adding serum exosomes isolated from patients with distant metastasis (M-exo)). Results. The in silico analysis demonstrated that PVT1 overexpression was associated with poor prognosis and increased expression of metastatic markers such as VEGFA and epidermal growth factor receptor (EGFR). This finding was further validated in a small cohort of patients with colon cancer in whom increased PVT1 expression was correlated with colon cancer incidence, disease recurrence, and distant metastasis. M-exo were enriched with PVT1 and VEGFA, and both migratory and invasive abilities of colon cancer cell lines increased when they were cocultured with M-exo. The metastasis-promoting effect was accompanied by increased expression of Twist1, vimentin, and MMP2. M-exo promoted metastasis in PDX mice. In vitro silencing of PVT1 reduced colon tumorigenic properties including migratory, invasive, colony forming, and tumorsphere generation abilities. Further analysis revealed that PVT1, VEGFA, and EGFR interact with and are regulated by miR-152-3p. Increased miR-152-3p expression reduced tumorigenesis, where increased tumorigenesis was observed when miR-152-3p expression was downregulated. Conclusion. Exosomal PVT1 promotes colon cancer metastasis through its association with EGFR and VEGFA expression. miR-152-3p targets both PVT1 and VEGFA, and this regulatory pathway can be explored for drug development and as a prognostic biomarker.

scholarly journals Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nobuko Koshikawa ◽  
Miho Akimoto ◽  
Jun-Ichi Hayashi ◽  
Hiroki Nagase ◽  
Keizo Takenaga
Keyword(s):  
Colon Cancer ◽  
Distant Metastasis ◽  
Pathogenic Mutations

Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and β-Catenin Predicts Distant Metastasis of Colon Cancer

2012 ◽  
Vol 19 (3) ◽  
pp. 710-720 ◽  
Author(s):  
Helge Siemens ◽  
Jens Neumann ◽  
Rene Jackstadt ◽  
Ulrich Mansmann ◽  
David Horst ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Distant Metastasis ◽  
Promoter Methylation ◽  
Elevated Expression

scholarly journals WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling

Oncotarget ◽  
2014 ◽  
Vol 5 (10) ◽  
pp. 2999-3011 ◽  
Author(s):  
Steffen Ormanns ◽  
Jens Neumann ◽  
David Horst ◽  
Thomas Kirchner ◽  
Andreas Jung
Keyword(s):  
Colon Cancer ◽  
Wnt Signaling ◽  
Distant Metastasis ◽  
Transcriptional Activity ◽  
Pi3k Signaling

scholarly journals ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients

2019 ◽  
Vol 8 (7) ◽  
pp. 1070 ◽  
Author(s):  
Yan-Jiun Huang ◽  
Yi-Hua Jan ◽  
Yu-Chan Chang ◽  
Hsing-Fang Tsai ◽  
Alexander TH Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Atp Synthase ◽  
Distant Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Hypoxia Inducible Factor ◽  
Xenograft Model ◽  
Metastatic Colon Cancer ◽  
Mesenchymal Transition ◽  
Ampk Signaling ◽  
Mouse Xenograft Model

Metastasis remains the major cause of death from colon cancer. We intend to identify differentially expressed genes that are associated with the metastatic process and prognosis in colon cancer. ATP synthase epsilon subunit (ATP5E) gene was found to encode the mitochondrial F0F1 ATP synthase subunit epsilon that was overexpressed in tumor cells compared to their normal counterparts, while other genes encoding the ATP synthase subunit were repressed in public microarray datasets. CRC cells in which ATP5E was silenced showed markedly reduced invasive and migratory abilities. ATP5E inhibition significantly reduced the incidence of distant metastasis in a mouse xenograft model. Mechanistically, increased ATP5E expression resulted in a prominent reduction in E-cadherin and an increase in Snail expression. Our data also showed that an elevated ATP5E level in metastatic colon cancer samples was significantly associated with the AMPK-AKT-hypoxia-inducible factor-1α (HIF1α) signaling axis; silencing ATP5E led to the degradation of HIF1α under hypoxia through AMPK-AKT signaling. Our findings suggest that elevated ATP5E expression could serve as a marker of distant metastasis and a poor prognosis in colon cancer, and ATP5E functions via modulating AMPK-AKT-HIF1α signaling.

scholarly journals Exploration of exact significance of lymph node ratio and construction of a novel stage in colon cancer with no distant metastasis

2019 ◽  
Vol Volume 11 ◽  
pp. 6841-6854 ◽  
Author(s):  
Yang Lv ◽  
Qing-Yang Feng ◽  
Song-Bin Lin ◽  
Yi-Hao Mao ◽  
Yu-Qiu Xu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Distant Metastasis ◽  
Lymph Node Ratio ◽  
Node Ratio

Preoperative Natural Killer Cell Activity as a Prognostic Factor for Distant Metastasis following Surgery for Colon Cancer

2003 ◽  
Vol 20 (5) ◽  
pp. 445-451 ◽  
Author(s):  
Eisuke Kondo ◽  
Keiji Koda ◽  
Nobuhiro Takiguchi ◽  
Kenji Oda ◽  
Kazuhiro Seike ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Distant Metastasis ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Killer Cell Activity

scholarly journals Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Yugang Wu ◽  
Min Jin ◽  
Huanbai Xu ◽  
Zhang Shimin ◽  
Songbing He ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Disease Free Survival ◽  
High Expression ◽  
Cancer Tissue ◽  
Vegf Expression ◽  
Tissue Samples ◽  
Node Metastasis

We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that combined high expression of any two of the three molecules (P=.028for HIF-1/CXCR4,P=.007for HIF-1/VEGF, andP=.004for CXCR4/VEGF) had stronger correlation with lymph node metastasis than did each alone. However, a relationship with distant metastasis is seen only with the combinations CXCR4/VEGF (P=.069for HIF-1/CXCR4,P=.062for HIF-1/VEGF, andP=.035for CXCR4/VEGF) as compared with those of single molecule high expression alone. Combined expression of all three molecules strongly correlates with lymph node metastasis and distant metastasis. The mRNA expression of HIF-1, CXCR4, and VEGF were quantified by real-time PCR in different colon cancer tissue samples, the experiment results shown that fresh colon tissue samples significantly overexpressed CXCR4 and VEGF mRNA compared with negative control. Therefore, the disease-free survival of all patients after curative resection can be considered in association with all three markers expression.

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