scholarly journals The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease

2021 ◽  
Vol Volume 14 ◽  
pp. 8355-8363
Author(s):  
Li Gu ◽  
Song Xue
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width Is Associated with Deterioration of Renal Function and Cardiovascular Morbidity and Mortality in Patients with Diabetic Kidney Disease

Life ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 301
Author(s):  
Stefanos Roumeliotis ◽  
Aikaterini Stamou ◽  
Athanasios Roumeliotis ◽  
Marios Theodoridis ◽  
Konstantinos Leivaditis ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Diabetic Kidney Disease ◽  
Independent Predictor ◽  
Cell Distribution ◽  
Distribution Width ◽  
Diabetic Kidney ◽  
Red Blood Cell Distribution

We sought to investigate the possible association between Red Blood Cell Distribution Width (RDW), vascular calcification, oxidative stress and renal function and all-cause/cardiovascular (CV) mortality, CV events and progression of kidney disease in a cohort of patients with Diabetic Kidney Disease (DKD). Carotid intima media thickness (cIMT) and oxidized low-density cholesterol were measured in 104 Type 2 Diabetes Mellitus (T2DM) patients with established DKD, distributed in all five stages of kidney disease and 38 diabetics with normal renal function. All patients were followed for 7 years with end-points all-cause and CV mortality, CV events and progression to End-Stage Renal Disease (ESRD). RDW was positively correlated with diabetes duration (r = 0.19, p = 0.023) and albuminuria (r = 0.29, p = 0.002). Multivariate regression analysis revealed that RDW was a strong, independent predictor of cIMT value (β = 0.031, p = 0.012). Kaplan-Meier curves and Cox proportional hazard models revealed that after adjustment for several cofounders, RDW was a significant and independent predictor for all-cause mortality, CV mortality, CV event and progression to ESRD (HR 1.75, p = 0.001, HR 2.03, p = 0.001, HR = 1.66, p < 0.0001 and HR 2.14, p = 0.001 respectively). RDW predicts mortality, CV events and deterioration of renal function in DKD, probably reflecting atherosclerosis.

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