scholarly journals Association Between Serum Calcium and Phosphorus Levels and Insulin-Like Growth Factor-1 in Chinese Children and Adolescents with Short Stature

2020 ◽  
Vol Volume 13 ◽  
pp. 1167-1173
Author(s):  
Minghui Sun ◽  
Wenhua Yan ◽  
Qianqian Zhao ◽  
Baolan Ji ◽  
Bo Ban ◽  
...  
Keyword(s):  
Growth Factor ◽  
Children And Adolescents ◽  
Short Stature ◽  
Serum Calcium ◽  
Chinese Children ◽  
Insulin Like Growth Factor ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels ◽  
Chinese Children And Adolescents

scholarly journals Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Panpan Wang ◽  
Baolan Ji ◽  
Qian Shao ◽  
Mei Zhang ◽  
Bo Ban
Keyword(s):  
Uric Acid ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Short Stature ◽  
Cross Sectional Study ◽  
Chinese Children ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chinese Children And Adolescents

Objective. The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS).Methods. A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.Results. A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P=0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β0.010, 95% CI 0.004–0.017;P=0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β  −0.055, 95% CI −0.081–−0.028;P<0.001) or more than 301 μmol/L (β  −0.005, 95% CI −0.013–0.002;P=0.174).Conclusions. This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.

scholarly journals Association between Growth Hormone-Insulin-Like Growth Factor-1 Axis Gene Polymorphisms and Short Stature in Chinese Children

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Yanhong Zhang ◽  
Mei Zhang ◽  
Yuntian Chu ◽  
Baolan Ji ◽  
Qian Shao ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Short Stature ◽  
Gene Polymorphisms ◽  
Chinese Children ◽  
Hormone Deficiency ◽  
Insulin Like Growth Factor ◽  
Genotype Frequencies ◽  
Ghr Gene ◽  
Significant Difference

Objective. This study was designed to analyze the association between the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis gene polymorphisms and short stature in Chinese children. Methods. 181 growth hormone deficiency (GHD) patients and 206 normal stature controls were enrolled to attend this study. Five single-nucleotide polymorphisms in the GH receptor (GHR) and 5 SNPs within the GH-signaling pathway were genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometry. We conducted an association study between these SNPs and the risk of developing short stature. Linkage disequilibrium analysis was performed using Haploview software and the associations of the SNPs frequencies with short stature were analyzed using X2 tests. Results. No significant difference was found in gender, weight, height, and BMI between the GHD and control groups, except that the age of GHD group was older than the control one. Allele and genotype frequencies were consistent with those expected from Hardy-Weinberg equilibrium. Compared with the controls, heterozygous genotype frequencies (CT) of rs12515480 and rs6873545 of GHR gene were significantly lower. Genotype frequencies of the other 8 SNPs did not show significant difference between these two groups. Considering a dominant model, an OR < 1 was observed for genotypes rs12515480 (OR = 0.532, P=0.019) and rs6873545 (OR = 0.587, P=0.017). Conclusions. The heterozygous genotypes of rs12515480 and rs6873545 of GHR gene were associated with decreased risk of GHD in Chinese children.

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