scholarly journals Effect of hepatic iron concentration and viral factors in chronic hepatitis C-infected patients with thalassemia major, treated with interferon and ribavirin

2011 ◽  
pp. 529 ◽  
Author(s):  
Besharati ◽  
Jafroodi ◽  
Assadi ◽  
Heidarzadeh ◽  
Besharati
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Iron Concentration ◽  
Thalassemia Major ◽  
Hepatic Iron ◽  
Hepatic Iron Concentration

Pilot Study of the Relationship Between Histologic Progression and Hepatic Iron Concentration in Chronic Hepatitis C

2003 ◽  
Vol 37 (5) ◽  
pp. 406-411 ◽  
Author(s):  
Anne M. Larson ◽  
Shari L. Taylor ◽  
Donald Bauermeister ◽  
Leonard Rosoff, ◽  
Kris V. Kowdley
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Pilot Study ◽  
Chronic Hepatitis C ◽  
Iron Concentration ◽  
Hepatic Iron ◽  
The Relationship ◽  
Hepatic Iron Concentration

scholarly journals Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy

2009 ◽  
Vol 51 (6) ◽  
pp. 331-336 ◽  
Author(s):  
Patricia da Silva Fucuta Pereira ◽  
Ivonete Sandra de Souza e Silva ◽  
Silvia Naomi de Oliveira Uehara ◽  
Christini Takemi Emori ◽  
Valéria Pereira Lanzoni ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Graphite Furnace ◽  
Antiviral Treatment ◽  
Iron Concentration ◽  
Hepatic Iron ◽  
Median Serum ◽  
Hepatic Iron Concentration

The complex interaction between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains controversial. The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C. A total of 50 patients who underwent pretreatment liver biopsy with assessment of HIC by graphite furnace atomic absorption spectroscopy and were subsequently submitted to antiviral treatment with interferon/peginterferon and ribavirin were included in the study. Patients with alcoholism, history of multiple blood transfusion, chronic kidney disease, hemolytic anemia and parenteral iron therapy were excluded. The iron related markers and HIC were compared between those who achieved an SVR and non-responders (NR) patients. The mean age was 45.7 years and the proportion of patients' gender was not different between SVR and NR patients. The median serum iron was 138 and 134 µg/dL (p = 0.9), the median serum ferritin was 152.5 and 179.5 ng/mL (p = 0.87) and the median HIC was 9.9 and 8.2 µmol/g dry tissue (p = 0.51), for SVR and NR patients, respectively. Thus, hepatic iron concentration, determined by a reliable quantitative method, was not a negative predictive factor of SVR in patients with chronic hepatitis C presenting mild to moderate hepatic iron accumulation.

Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

1995 ◽  
Vol 108 (4) ◽  
pp. 1104-1109 ◽  
Author(s):  
John K. Olynyk ◽  
K.Rajender Reddy ◽  
Adrian M. di Bisceglie ◽  
Lennox J. Jeffers ◽  
Talley I. Parker ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Iron Concentration ◽  
Interferon Alfa ◽  
Hepatic Iron ◽  
Hepatic Iron Concentration

Increase in hepatic iron stores following prolonged therapy with ribavirin in patients with chronic hepatitis C

1994 ◽  
Vol 21 (6) ◽  
pp. 1109-1112 ◽  
Author(s):  
Adrian M. Di Bisceglie ◽  
Bruce R. Bacon ◽  
David E. Kleiner ◽  
Jay H. Hoofnagle
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatic Iron ◽  
Iron Stores ◽  
Prolonged Therapy
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