scholarly journals Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold

2011 ◽  
pp. 45 ◽  
Author(s):  
Mostafa Yakoot ◽  
A Salem
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Efficacy And Safety ◽  
The Common

scholarly journals Vitamin C and the common cold

1992 ◽  
Vol 67 (1) ◽  
pp. 3-16 ◽  
Author(s):  
Harri Hemilä
Keyword(s):  
Vitamin C ◽  
Clinical Significance ◽  
Common Cold ◽  
Antioxidant Property ◽  
Considerable Decrease ◽  
Infected People ◽  
Supplemental Vitamin ◽  
The Subject ◽  
The Common

The effect of vitamin C on the common cold has been the subject of several studies. These studies do not support a considerable decrease in the incidence of the common cold with supplemental vitamin C. However, vitamin C has consistently decreased the duration of cold episodes and the severity of symptoms. The benefits that have been observed in different studies show a large variation and, therefore, the clinical significance may not be clearly inferred from them. The biochemical explanation for the benefits may be based on the antioxidant property of vitamin C. In an infection, phagocytic leucocytes become activated and they produce oxidizing compounds which are released from the cell. By reacting with these oxidants, vitamin C may decrease the inflammatory effects caused by them. Scurvy, which is caused by a deficiency in vitamin C, is mostly attributed to the decreased synthesis of collagen. However, vitamin C also participates in several other reactions, such as the destruction of oxidizing substances. The common cold studies indicate that the amounts of vitamin C which safely protect from scurvy may still be too low to provide an efficient rate for other reactions, possibly antioxidant in nature, in infected people.

scholarly journals Bias against Vitamin C in Mainstream Medicine: Examples from Trials of Vitamin C for Infections

Life ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 62
Author(s):  
Harri Hemilä ◽  
Elizabeth Chalker
Keyword(s):  
Clinical Trials ◽  
Vitamin C ◽  
Common Cold ◽  
Evidence Based Medicine ◽  
Evidence Based ◽  
The Third ◽  
Nutritional Recommendations ◽  
Mainstream Medicine ◽  
The Common ◽  
Based Medicine

Evidence has shown unambiguously that, in certain contexts, vitamin C is effective against the common cold. However, in mainstream medicine, the views on vitamin C and infections have been determined by eminence-based medicine rather than evidence-based medicine. The rejection of the demonstrated benefits of vitamin C is largely explained by three papers published in 1975—two published in JAMA and one in the American Journal of Medicine—all of which have been standard citations in textbooks of medicine and nutrition and in nutritional recommendations. Two of the papers were authored by Thomas Chalmers, an influential expert in clinical trials, and the third was authored by Paul Meier, a famous medical statistician. In this paper, we summarize several flaws in the three papers. In addition, we describe problems with two recent randomized trial reports published in JAMA which were presented in a way that misled readers. We also discuss shortcomings in three recent JAMA editorials on vitamin C. While most of our examples are from JAMA, it is not the only journal with apparent bias against vitamin C, but it illustrates the general views in mainstream medicine. We also consider potential explanations for the widespread bias against vitamin C.

scholarly journals Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold

2009 ◽  
Vol 21 (5) ◽  
pp. 295-300 ◽  
Author(s):  
Kathryn A. Heimer ◽  
Ann Marie Hart ◽  
Linda Gore Martin ◽  
Sherrie Rubio-Wallace
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
The Common

Authors’ response to letter to the editor: “Meta-analysis on vitamin C and the common cold in children may be misleading”

2019 ◽  
Vol 75 (12) ◽  
pp. 1749-1750
Author(s):  
Philippe Vorilhon ◽  
Bastien Arpajou ◽  
Hélène Vaillant Roussel ◽  
Étienne Merlin ◽  
Bruno Pereira ◽  
...  
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Meta Analysis ◽  
Letter To The Editor ◽  
The Common

Vitamin C and the Common Cold

BMJ ◽  
1951 ◽  
Vol 1 (4711) ◽  
pp. 887-887 ◽  
Author(s):  
J. M. Fletcher ◽  
I. C. Fletcher
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
The Common

Vitamin C and the common cold Using identical twins as controls

1981 ◽  
Vol 2 (8) ◽  
pp. 411-412 ◽  
Author(s):  
Alan B. Carr ◽  
Rosmarie Einstein ◽  
Lawrence Y. C. Lai ◽  
Nicholas G. Martin ◽  
Graham A. Starmer
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Identical Twins ◽  
The Common

scholarly journals Vitamin C intake and susceptibility to the common cold

1997 ◽  
Vol 77 (1) ◽  
pp. 59-72 ◽  
Author(s):  
Harri Hemilä
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Potential Effect ◽  
Dietary Vitamin ◽  
High Dose ◽  
Plasma Vitamin ◽  
Vitamin C Supplementation ◽  
The Common ◽  
The Uk

Although the role of vitamin C in common cold incidence had been studied extensively, the level of vitamin C intake has not been unequivocally shown to affect the incidence of colds. In the present study the six largest vitamin C supplementation (≥ 1 g/d) studies, including over 5000 episodes in all, have been analysed, and it is shown that common cold incidence is not reduced in the vitamin C-supplemented groups compared with the placebo groups (pooled rate ratio (RR) 0·99; 95% CI 0·93, 1·04). Consequently these six major studies give no evidence that high-dose vitamin C supplementation decreases common cold incidence in ordinary people. Nevertheless, the analysis was continued with the hypothesis that vitamin C intake may affect common cold susceptibility in specific groups of people. It was assumed that the potential effect of supplementation might be most conspicuous in subjects with low dietary vitamin C intake. The average vitamin C intake has been rather low in the UK and plasma vitamin C concentrations are in general lower in males than in females. In four studies with British females vitamin C supplementation had no marked effect on common cold incidence (pooled RR 0·95; 95% CI 0·86, 1·04). However, in four studies with British male schoolchildren and students a statistically highly significant reduction in common cold incidence was found in groups supplemented with vitamin C (pooled RR 0·70; 95% CI 0·60, 0·81). Thus, these studies with British males indicate that vitamin C intake has physiological effects on susceptibility to common cold infections, although the effect seems quantitatively meaningful only in limited groups of people and is not very large.

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