scholarly journals Metagenomic Next-Generation Sequencing Assists in the Diagnosis of Gardnerella vaginalis in Males with Pleural Effusion and Lung Infection: A Case Report and Literature Review

2021 ◽  
Vol Volume 14 ◽  
pp. 5253-5259
Author(s):  
Simin Wu ◽  
Weihua Hu ◽  
Wei Xiao ◽  
Yongxia Li ◽  
Yan Huang ◽  
...  
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Pleural Effusion ◽  
Literature Review ◽  
Lung Infection ◽  
Gardnerella Vaginalis ◽  
Next Generation ◽  
Generation Sequencing

Diagnosis of NUT Carcinoma Despite False-Negative Next-Generation Sequencing Results: A Case Report and Literature Review

2021 ◽  
Vol Volume 14 ◽  
pp. 4621-4633
Author(s):  
Xi Wang ◽  
Jinping Wang ◽  
Xue Luo ◽  
Jinxi Lu ◽  
Liang Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Literature Review ◽  
False Negative ◽  
Next Generation ◽  
Nut Carcinoma ◽  
Generation Sequencing

scholarly journals Next Generation Sequencing for the Prediction of the Antibiotic Resistance in Helicobacter pylori: A Literature Review

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 437
Author(s):  
Ilaria Maria Saracino ◽  
Matteo Pavoni ◽  
Angelo Zullo ◽  
Giulia Fiorini ◽  
Tiziana Lazzarotto ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Next Generation Sequencing ◽  
Literature Review ◽  
Molecular Mechanisms ◽  
World Health ◽  
Next Generation ◽  
Culture Methods ◽  
Phenotypic Resistance ◽  
H Pylori ◽  
Generation Sequencing

Background and aims: Only a few antimicrobials are effective against H. pylori, and antibiotic resistance is an increasing problem for eradication therapies. In 2017, the World Health Organization categorized clarithromycin resistant H. pylori as a “high-priority” bacterium. Standard antimicrobial susceptibility testing can be used to prescribe appropriate therapies but is currently recommended only after the second therapeutic failure. H. pylori is, in fact, a “fastidious” microorganism; culture methods are time-consuming and technically challenging. The advent of molecular biology techniques has enabled the identification of molecular mechanisms underlying the observed phenotypic resistance to antibiotics in H. pylori. The aim of this literature review is to summarize the results of original articles published in the last ten years, regarding the use of Next Generation Sequencing, in particular of the whole genome, to predict the antibiotic resistance in H. pylori.Methods: a literature research was made on PubMed. The research was focused on II and III generation sequencing of the whole H. pylori genome. Results: Next Generation Sequencing enabled the detection of novel, rare and complex resistance mechanisms. The prediction of resistance to clarithromycin, levofloxacin and amoxicillin is accurate; for other antimicrobials, such as metronidazole, rifabutin and tetracycline, potential genetic determinants of the resistant status need further investigation.

scholarly journals Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Phedias Diamandis ◽  
Ruben Ferrer-Luna ◽  
Raymond Y. Huang ◽  
Rebecca D. Folkerth ◽  
Azra H. Ligon ◽  
...  
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Generation Sequencing
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