scholarly journals Investigation of One Familial Cluster of COVID-19 in Taiwan: Differentiation of Genetic Variation Among Isolates and Implications for Epidemiological Investigation and Surveillance by Genomic Assay

2021 ◽  
Vol Volume 14 ◽  
pp. 971-977
Author(s):  
Ming-Jr Jian ◽  
Hsing-Yi Chung ◽  
Chih-Kai Chang ◽  
Shan-Shan Hsieh ◽  
Jung-Chung Lin ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Epidemiological Investigation ◽  
Familial Cluster

scholarly journals Pediatric COVID-19 in Southern California: clinical features and viral genetic diversity

2020 ◽  
Author(s):  
U Pandey ◽  
R Yee ◽  
M Precit ◽  
M Bootwalla ◽  
A Ryutov ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Genetic Variation ◽  
Disease Severity ◽  
Clinical Features ◽  
Southern California ◽  
Evolutionary Rate ◽  
Rna Viruses ◽  
Epidemiological Investigation ◽  
Multiple Introductions ◽  
Clinical Presentations

AbstractAs the pandemic enters its fifth month, information regarding COVID-19 in children is rapidly evolving. Here, we explore clinical features and SARS-CoV-2 genetic variation in children presenting with COVID-19. We observed diverse clinical presentations and identified association between disease severity, viral load and age. SARS-CoV-2 genomes from the patients showed limited number of variations and an evolutionary rate comparable to other RNA viruses. We did not identify correlation between disease severity and viral genetic variations. Epidemiological investigation revealed multiple introductions of virus into Southern California.

scholarly journals Epidemiological and clinical characteristics of a familial cluster of COVID-19

2020 ◽  
Vol 148 ◽  
Author(s):  
Yong Sun ◽  
Lin Tian ◽  
Xiaomei Du ◽  
Hua Wang ◽  
Yueshan Li ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Family Member ◽  
Incubation Period ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Epidemiological Investigation ◽  
Radiological Findings ◽  
Wuhan City ◽  
Familial Cluster ◽  
Family Cluster

Abstract We report a family cluster of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involving five patients in a family cluster in Dazhou, China, including the epidemiological, clinical, laboratory and radiological findings. Three-generation transmission was observed. Through epidemiological investigation, we observed asymptomatic transmission to a cohabiting family member, as well as person-to-person transmission of SARS-CoV-2 outside Wuhan city. The asymptomatic transmission demonstrated here provides evidence that there could be a greater risk of Coronavirus Disease 2019 (COVID-19) spread. This cluster also demonstrated that COVID-19 is transmissible during the incubation period of an asymptomatic person. Early isolation and treatment, stressing prevention of cluster outbreaks, could help prevent further spread of the epidemic.

Genetic variation in the human interleukin 4 (IL4) gene is associated with gallstone susceptibility

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
A Tönjes ◽  
A Tönjes ◽  
T Strauch ◽  
C Ruffert ◽  
J Mössner ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Interleukin 4
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