scholarly journals Prevalence, Associated Risk Factors and Rifampicin Resistance Pattern of Pulmonary Tuberculosis Among Children at Debre Markos Referral Hospital, Northwest, Ethiopia

2020 ◽  
Vol Volume 13 ◽  
pp. 3863-3872
Author(s):  
Mulusew Liyew Ayalew ◽  
Wubet Birhan Yigzaw ◽  
Abiye Tigabu ◽  
Baye Gelaw Tarekegn
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Northwest Ethiopia ◽  
Referral Hospital ◽  
Rifampicin Resistance ◽  
Resistance Pattern ◽  
Debre Markos ◽  
Associated Risk Factors

scholarly journals Clinical Outcome of Meningitis and Its Risk Factors Among Children Admitted in Debre Markos Referral Hospital Pediatric Ward, Northwest Ethiopia,2019

2020 ◽  
Author(s):  
Hailemariam Abiy ◽  
Zelalem Shiferaw ◽  
Yilkal Tafere
Keyword(s):  
Risk Factors ◽  
Health Care Team ◽  
Cross Sectional Study ◽  
Northwest Ethiopia ◽  
Referral Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Debre Markos ◽  
Hospital Pediatric

Abstract Background:Meningitis remains a major cause of mortality and morbidity in patients in many countries of the world including Ethiopia. This study aimed to assess clinical outcomes and associated risk factors of meningitis among children who were admitted to Debre Markos Referral Hospital from January 2017 to December 2018.A backward stepwise multivariable logistic regression was applied with 95% confidence interval of odds ratio (OR) andstatistical significance less than 0.05 p-value were taken as cut off value.Methods:A retrospective cross-sectional study was conducted. The study includesAll pediatric meningitis 211 cases from the age of one month to fourteen who were admitted due to meningitis in Debre Markos Referral Hospitalfrom January 2017 to December 2018.Data were entered, cleaned, and analyzed using SPSS for Windows, version 20.Results:The study showed that 18.9% of children with meningitis developed bad outcomes. In this study, children who were a worse clinical condition at admission 6 times more likely to develop bad outcomes [AOR= 6.321(2.121, 18.837)] and having a seizure at admission almost 19 times more likely to develop bad outcomes [AOR=18.953(6.677, 53.799)]. Conclusions:About one in five children with meningitis developed bad outcomes. The health care team should due attention to improving care for patients with severe conditions at admission and seizures were the alarming signs for poor outcomes in children.

scholarly journals Prevalence, risk factors and antifungal susceptibility pattern of Candida species among pregnant women at Debre Markos Referral Hospital, Northwest Ethiopia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Alem Tsega ◽  
Feleke Mekonnen
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Amphotericin B ◽  
Antifungal Susceptibility ◽  
Northwest Ethiopia ◽  
Candida Krusei ◽  
Referral Hospital ◽  
Vaginal Candidiasis ◽  
Debre Markos ◽  
Multiple Drugs

Abstract Background Candida is the commonest opportunistic fungi in human. Candida species cause diverse types of diseases. Vaginal candidiasis has been reported as one of the most common type of fungal diseases among pregnant women. However; In Ethiopia, due to scarcity of data, much has not been documented regarding the prevalence of Candida among pregnant women. Objective This study aimed to determine the prevalence, possible risk factors and antifungal susceptibility profile of Candida species among pregnant women attending Debre Markos Referral Hospital, Northwest Ethiopia. Method A cross-sectional study was conducted from February to May 2017. A total of 384 pregnant women were included using a systematic random sampling technique. Vaginal specimens were collected, inoculated on Candida HiV eg culture Medium and incubated at 37 °C for 24 h.Colonies were identified using standard microbiological methods and selected for further Candida Species identification using Hi Chrome agar and germ tube test. Fungal suspensions were made and adjusted at 0.5% MacFarland standard. Modified Kirby-Bauer disk diffusion technique was used for antifungal susceptibility. Data was entered, cleaned using Ep info version 7.1and transported to Statistical Packages for Social Sciences (SPSS) version 21 for analysis. Descriptive statistics and logistic regression were performed. P. value < 0.05 at 95% confidence interval was considered as statistically significant. Result From a total of 384 study participants, 96 (25%) were positive for Candida species. The predominant Candida species was Candida albicans 54(56.25%) followed by Candida krusei 21(21.9%), Candida glabrata 17(17.7%), Candida tropicalis 1(1%) and 3(3.1%) were other Candida species. Contraceptive use (AOR: 0.394; 95% CI = 0.20–0.74) and prolonged antibiotic uses (AOR: 0.393; 95% CI = 0.21–0.72) were risk factors. All isolates except Candida krusei were 100% susceptible to amphotericin-B. Resistance rate was high against itraconazole and Ketoconazole 55(57.3%). Conclusion The prevalence of Candida species among symptomatic pregnant women was significantly higher than asymptomatic pregnant women. Age group between 26 and 40 years was significantly associated with Candida infection. Amphotericin B was the most sensitive antifungal drug. High rate of multiple drugs resistant Candida species was detected. Therefore Symptomatic women should be routinely screened and treated.

scholarly journals Carriage Rate of Neisseria meningitidis, Antibiotic Susceptibility Pattern and Associated Risk Factors among Primary School Children in Gondar town, Northwest Ethiopia

2019 ◽  
Author(s):  
Zelalem Tefera ◽  
Feleke Mekonnen ◽  
Moges Tiruneh ◽  
Teshome Belachew
Keyword(s):  
Risk Factors ◽  
Primary School ◽  
School Children ◽  
Northwest Ethiopia ◽  
Primary School Children ◽  
Resistance Pattern ◽  
Susceptibility Pattern ◽  
Carriage Rate ◽  
Gondar Town ◽  
Associated Risk Factors

Abstract Background Invasive meningococcal disease has 70–80% mortality. Globally, 1.2 million estimated cases were reported with ~135,000 deaths annually. In African meningitis belt bacterial meningitis remains a serious threat to health accounting an estimated 500,000 cases of invasive meningococcal disease annually.In Ethiopia, specifically in our study area, limited information is found on the oropharyngeal carriage, antimicrobial resistance pattern and associated risk factors for N. meningitidis especially in school children. So, the aim of this study was to assess oropharyngeal carriage rate of N. meningitidis, antibiotic susceptibility pattern and associated risk factors among primary school children in Gondar town, Northwest Ethiopia. Methods A cross sectional prospective study was conducted from January-April, 2019 among primary school children. Multi stage simple random sampling technique was used. A total of 524 oropharyngeal swabs were collected using sterile plastic cotton swabs. Modified Thayer Martin media was used for primary inoculation. Antimicrobial susceptibility pattern was done on Muller-Hinton agar supplemented with 5% sheep blood. Logistic regression model was used to see the association between dependent and independent variables. P ≤0.05 at 95% CI was considered as statistically significant. Results A total of 53(10.1%) (CI: 7.6-12.8) N. meningitidis isolates were identified. Serogroup A 13 (24.5%) was the most prevalent followed by Y/W135 11(20.7%) whereas serogroup B 4(7.6%) was the least identified. Meningococcal isolates were resistant to ciprofloxacin (45.3%) and trimethoprim-sulfamethoxazole (73.6%). Overall, most of meningococcal isolates showed high level of multidrug resistance with the rate of 32(60.4%). Meningococcal carriage rate was associated with family size, tonsillectomy, passive smoking, number of students per class, sharing utensils, history of visiting healthcare institutions and indoor kitchen. Conclusion Neisseria meningitidis prevalence in the present study was high. Serogroup A and W135/Y was the most prevalent isolate. High multidrug resistance pattern was observed.

scholarly journals Prevalence, Antimicrobial Susceptibility Patterns, and Risk Factors Associated with Enterococci among Pediatric Patients at Dessie Referral Hospital, Northeastern Ethiopia

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Admasu Abera ◽  
Mihret Tilahun ◽  
Saba Gebremichael Tekele ◽  
Melaku Ashagrie Belete
Keyword(s):  
Risk Factors ◽  
Pediatric Patients ◽  
Multidrug Resistant ◽  
Body Fluids ◽  
Referral Hospital ◽  
Health Concern ◽  
Resistance Pattern ◽  
History Of ◽  
Associated Risk Factors ◽  
Dessie Referral Hospital

Background. Enterococcus species, which is previously considered as medically not important, now becomes one of the leading causes of nosocomial infections. Even though it becomes the most public health concern and emerging multidrug-resistant pathogen, there is no enough data in the study area. Objective. To determine the prevalence, antimicrobial resistance pattern, and associated risk factors of enterococci infection in pediatric patients. Methods. A hospital-based cross-sectional study was conducted from February to May 2019 at Dessie Referral Hospital, Northeastern Ethiopia. A total of 403 pediatric patients were included in the study, and a pretested structured questionnaire was used to collect sociodemographic and risk factor-related data. Clinical samples such as urine, blood, wound swabs, discharges, and other body fluids were collected aseptically and inoculated on to Bile Esculin Azide Agar, and colony characteristics, Gram stain, catalase, salt, and temperature tolerance tests were employed for bacterial identification. Antimicrobial sensitivity tests were performed using the modified Kirby-Bauer disk diffusion method. Data was entered into SPSS software version 25 and descriptive statistics; bivariate and multivariate logistic regression analyses were performed. In all cases, a P value ≤ 0.05 with corresponding 95% confidence interval were considered as statistically significant. Result. The overall prevalence of enterococci was 2.7% (11/403). Of which, the highest number of enterococci infection was recovered from urine sample (54.5%) followed by blood (27.3%), wound swab (9.1%), and other body fluids (9%). The overall multidrug resistance rate was 54.5%. Higher drug resistance pattern was observed against tetracycline, chloramphenicol, and amoxicillin/clavulanate. Having history of invasive procedure ( P < 0.001 ), chronic illness ( P < 0.001 ) and previous admission history of the children ( P < 0.001 ) were statistically significant associated risk factors for pediatrics enterococci infection. Conclusion. The prevalence of enterococci from pediatric patients in this study was relatively low compared to other studies. Significant rates of MDR and VRE were identified, and the risk of infection became high when children had a history of different chronic illnesses and history of admission and underwent invasive treatment procedures. Therefore, efforts should be made to prevent enterococci infections and spread of multidrug-resistant enterococci.

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