scholarly journals Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant Staphylococcus aureus Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis

2020 ◽  
Vol Volume 13 ◽  
pp. 2921-2927 ◽  
Author(s):  
Katsura Hayakawa ◽  
Tetsuo Yamaguchi ◽  
Daisuke Ono ◽  
Hajime Suzuki ◽  
Jiro Kamiyama ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Necrotizing Pneumonia ◽  
Methicillin Resistant ◽  
Intrafamilial Transmission

Severe Sepsis Attributable to Community-Associated Methicillin-Resistant Staphylococcus aureus: An Emerging Fatal Problem

2007 ◽  
Vol 73 (7) ◽  
pp. 684-687 ◽  
Author(s):  
Eric T. Castaldo ◽  
Edmund Y. Yang
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Soft Tissues ◽  
Hospital Admissions ◽  
Primary Source ◽  
Necrotizing Pneumonia ◽  
Inclusion Criteria ◽  
Methicillin Resistant ◽  
Cardiorespiratory Failure ◽  
Source Of Infection

We observed a number of cases of sepsis from bacteremia in children from community-associated methicillin-resistant Staphylococcus aureus (MRSA), which led us to study its patterns of infection and outcome. A retrospective review identifying children admitted to our institution with blood culture-proven community-associated MRSA sepsis over a 2-year period was performed. The inclusion criteria were younger than 19 years old, two or more blood cultures for MRSA within 48 hours of admission, evidence of systemic inflammatory response syndrome, and no prior hospital admissions within 6 months. Eight patients were included; seven required mechanical ventilation. Vasopressors were required in seven patients. Four patients required extra-corporeal membrane oxygenation. Four patients had culture-proven septic arthritis or thrombophlebitis and three of these patients developed bilateral necrotizing pneumonia. Bilateral necrotizing pneumonia was identified in the other four patients, but the primary source of infection was never identified. The overall intact neurologic survival was 50 per cent. Children with severe community-associated MRSA sepsis can rapidly progress to cardiorespiratory failure. Mortality appears to be high, and children may benefit from a search of their soft tissues and joints to identify the source of infection to prevent embolic dissemination.

scholarly journals Necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus

2021 ◽  
Author(s):  
Toshiki Hiramatsu ◽  
Kazunori Tobino
Keyword(s):  
Staphylococcus Aureus ◽  
Progressive Disease ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Fatal Case ◽  
Case Fatality ◽  
Necrotizing Pneumonia ◽  
Methicillin Resistant ◽  
Appropriate Treatment ◽  
Mrsa Infection ◽  
Vancomycin Treatment

We report a fatal case of methicillin-resistant Staphylococcus aureus (MRSA)-induced necrotizing pneumonia that was refractory to adequate vancomycin treatment (trough value, 13.1 µg/mL), drainage of a hydropneumothorax, and veno-arterial extracorporeal membrane oxygenation. MRSA infection can cause rapidly progressive disease with a high case fatality rate, even with appropriate treatment.

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