scholarly journals Co-Incidence of Type II Topoisomerase Mutations and Efflux Expression in High Fluoroquinolone Resistant Enterococcus faecalis Isolated from Urinary Tract Infections

2020 ◽  
Vol Volume 13 ◽  
pp. 553-559
Author(s):  
Sarvenaz Esfahani ◽  
Roya Ahmadrajabi ◽  
Hamidreza Mollaei ◽  
Fereshteh Saffari
Keyword(s):  
Urinary Tract ◽  
Enterococcus Faecalis ◽  
Urinary Tract Infections ◽  
Type Ii ◽  
Tract Infections

scholarly journals Urinary Excretion and Bactericidal Activities of Gemifloxacin and Ofloxacin after a Single Oral Dose in Healthy Volunteers

2001 ◽  
Vol 45 (12) ◽  
pp. 3524-3530 ◽  
Author(s):  
Christoph K. Naber ◽  
Michaela Hammer ◽  
Martina Kinzig-Schippers ◽  
Christian Sauber ◽  
Fritz Sörgel ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Urinary Tract ◽  
Urinary Excretion ◽  
Enterococcus Faecalis ◽  
Urinary Tract Infections ◽  
Parent Drug ◽  
Oral Dosage ◽  
Tract Infections ◽  
Cumulative Excretion

ABSTRACT In a randomized crossover study, 16 volunteers (8 men, 8 women) received single oral doses of 320 mg of gemifloxacin and 400 mg of ofloxacin on two separate occasions in the fasting state to assess the urinary excretion and urinary bactericidal titers (UBTs) at intervals for up to 144 h. Ofloxacin showed higher concentrations in urine compared with those of gemifloxacin. The median (range) cumulative excretion of gemifloxacin was 29.7% (8.4 to 48.7%) of the parent drug administered, and median (range) cumulative excretion of ofloxacin was 84.3% (46.5 to 95.2%) of the parent drug administered. The UBTs, i.e., the highest twofold dilutions (with antibiotic-free urine as the diluent) of urine that were still bactericidal, were determined for a reference strain and nine uropathogens for which the MICs of gemifloxacin and ofloxacin were as follows:Escherichia coli ATCC 25922, 0.016 and 0.06 μg/ml, respectively; Klebsiella pneumoniae, 0.03 and 0.06 μg/ml, respectively; Proteus mirabilis, 0.125 and 0.125 μg/ml, respectively; Escherichia coli, 0.06 and 0.5 μg/ml, respectively; Pseudomonas aeruginosa, 1 and 4 μg/ml, respectively; Staphylococcus aureus, 0.008 and 0.25 μg/ml, respectively; Enterococcus faecalis, 0.06 and 2 μg/ml, respectively;Staphylococcus aureus, 0.25 and 4 μg/ml, respectively;Enterococcus faecalis, 0.5 and 32 μg/ml, respectively; and Staphylococcus aureus, 2 and 32 μg/ml, respectively. Generally, the UBTs for gram-positive uropathogens were higher for gemifloxacin than for ofloxacin and the UBTs for gram-negative uropathogens were higher for ofloxacin than for gemifloxacin. According to the UBTs, ofloxacin-resistant uropathogens (MICs, ≥4 mg/liter) should also be considered gemifloxacin resistant. Although clinical trials have shown that gemifloxacin is effective for the treatment of uncomplicated urinary tract infections, whether an oral dosage of 320 mg of gemifloxacin once daily is also adequate for the treatment of complicated urinary tract infections has yet to be confirmed.

scholarly journals A Retrospective Study on Antibiotic Microbial Sensitivity in Type II Diabetes Mellitus Patients with Urinary Tract Infections

2021 ◽  
Vol 13 (1) ◽  
pp. 63-67
Author(s):  
Anitha Kuttiappan ◽  
Sasi Prasad Dondapati ◽  
Tejasri Kothinti ◽  
Manoja Bayyapureddy ◽  
Jyosthna Kothapalli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Retrospective Study ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Tract Infections

scholarly journals Nitrofurantoin Is Active against Vancomycin-Resistant Enterococci

2001 ◽  
Vol 45 (1) ◽  
pp. 324-326 ◽  
Author(s):  
George G. Zhanel ◽  
Daryl J. Hoban ◽  
James A. Karlowsky
Keyword(s):  
Urinary Tract ◽  
Effective Treatment ◽  
Enterococcus Faecalis ◽  
Urinary Tract Infections ◽  
Enterococcus Faecium ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Enterococcus Gallinarum ◽  
Tract Infections

ABSTRACT The activity of nitrofurantoin was tested against 300 isolates ofEnterococcus faecium, Enterococcus faecalis, and Enterococcus gallinarum. No isolates tested were resistant to nitrofurantoin (MIC, ≥128 μg/ml), including vancomycin-resistant E. faecium isolates withvanA- and vanB-positive genotypes and vancomycin-resistant E. gallinarum isolates. We conclude that nitrofurantoin may provide effective treatment of urinary tract infections caused by vancomycin-resistant enterococci.

Predictive factors for Enterococcus faecalis in complicated community‐acquired urinary tract infections in older patients

2019 ◽  
Vol 20 (3) ◽  
pp. 183-186 ◽  
Author(s):  
Manuel Madrazo ◽  
Ana Esparcia ◽  
Juan Alberola ◽  
Anna Ferrer ◽  
José M Eiros ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Enterococcus Faecalis ◽  
Urinary Tract Infections ◽  
Predictive Factors ◽  
Older Patients ◽  
Tract Infections
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