scholarly journals Rapid Diagnosis Of Multidrug-Resistant Tuberculosis Impacts Expenditures Prior To Appropriate Treatment: A Performance And Diagnostic Cost Analysis

2019 ◽  
Vol Volume 12 ◽  
pp. 3549-3555
Author(s):  
Xuezheng Li ◽  
Yunfeng Deng ◽  
Junling Wang ◽  
Hui Jing ◽  
Wei Shu ◽  
...  
Keyword(s):  
Cost Analysis ◽  
Multidrug Resistant ◽  
Rapid Diagnosis ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Appropriate Treatment ◽  
Diagnostic Cost ◽  
A Performance

scholarly journals Genetic characterization of N-acetyltransferase 2 variants in acquired multidrug-resistant tuberculosis in Indonesia

2021 ◽  
Author(s):  
Rika Yuliwulandari ◽  
Kinasih Prayuni ◽  
Intan Razari ◽  
Retno W Susilowati ◽  
Yenni Zulhamidah ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Resistance Rate ◽  
Published Data ◽  
Drug Induced ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Appropriate Treatment ◽  
Acetylator Status ◽  
Mdr Tb

Background: Owing to the high resistance rate of tuberculosis (TB) to isoniazid, which is metabolized by N-acetyltransferase 2 (NAT2), we investigated the associations between NAT2 variants and multidrug-resistant (MDR)-TB. Materials & methods: The acetylator status based on NAT2 haplotypes of 128 patients with MDR-TB in Indonesia were compared with our published data from patients with anti-TB drug-induced liver injury (AT-DILI), TB and the general population. Results: NAT2*4 was more frequent in the MDR-TB group than in the AT-DILI group, TB controls and general controls. NAT2*4/*4 was significantly more frequent in patients with MDR-TB than in those with AT-DILI. NAT2*5B/7B, *6A/6A and *7B/*7B were detected at lower frequencies in patients with AT-DILI. Rapid acetylators were significantly more frequent in patients with MDR-TB than in those with AT-DILI. Conclusion: These results provide an initial data for optimizing TB treatment in the Indonesian population, and suggest that NAT2 genotyping may help to select appropriate treatment by predicting TB-treatment effect.

scholarly journals Rapid diagnosis of pyrazinamide-resistant multidrug-resistant tuberculosis using a molecular-based diagnostic algorithm

2014 ◽  
Vol 20 (10) ◽  
pp. 1015-1020 ◽  
Author(s):  
S.O. Simons ◽  
T. van der Laan ◽  
A. Mulder ◽  
J. van Ingen ◽  
L. Rigouts ◽  
...  
Keyword(s):  
Diagnostic Algorithm ◽  
Multidrug Resistant ◽  
Rapid Diagnosis ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Primary multidrug-resistant tuberculosis and its control implications in the State of Amazonas, Brazil: report of 3 cases

2012 ◽  
Vol 45 (4) ◽  
pp. 530-532
Author(s):  
Marlucia Silva Garrido ◽  
Anette Chrusciak Talhari ◽  
Irineide Assumpção Antunes ◽  
Joycenea da Silva Matsuda ◽  
Etelvina das Graças Zaranza ◽  
...  
Keyword(s):  
Control Program ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Appropriate Treatment ◽  
National Tuberculosis Control Program ◽  
Clinical Complexity ◽  
National Tuberculosis ◽  
Proportion Method ◽  
Alternative Medications

The occurrence of tuberculosis with first-line multidrug resistance leads to the use of alternative medications, often at higher costs, longer treatment periods, and greater clinical complexity. Here, we report 3 patients with multidrug-resistant tuberculosis. One patient with human immunodeficiency virus died before the sensitivity test was performed. The early diagnosis of multidrug-resistant tuberculosis and appropriate treatment should be priorities of the National Tuberculosis Control Program in order to break the chain of transmission. In addition, the possibility of substituting the proportion method with more modern and faster techniques should be urgently evaluated.

scholarly journals Time to appropriate treatment in patients with multidrug-resistant tuberculosis in South Korea: Are we still in 2010?

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0216084 ◽  
Author(s):  
Eun-Jung Jo ◽  
Seyeon Park ◽  
Kyu Min Lee ◽  
Insu Kim ◽  
Jung Seop Eom ◽  
...  
Keyword(s):  
South Korea ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Appropriate Treatment

scholarly journals Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Richard P. Sullivan ◽  
Hazel F. Goldberg ◽  
Ross S. Mellick ◽  
Jeffrey J. Post
Keyword(s):  
Successful Treatment ◽  
Multidrug Resistant ◽  
Rapid Diagnosis ◽  
Duration Of Therapy ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Night Sweats ◽  
History Of ◽  
The Central Nervous System

A 21-year-old Bangladesh-born man presented with a month history of evolving neurological symptoms in the context of a six-month history of fever, night sweats, and axillary lymphadenopathy. He was subsequently diagnosed with multiple multidrug resistant intracranial tuberculomata and was successfully treated over two years. Intracranial multidrug resistant tuberculosis has a high mortality and successful treatment is rarely reported. Management is complex and requires consideration of the penetration and likely effect of antituberculous agents within the central nervous system. We discuss the role of various antituberculous agents, the duration of therapy, the utility of corticosteroids, the value of intrathecal and systemic therapy, and the need for rapid diagnosis.

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