scholarly journals Genetic basis for metronidazole and clarithromycin resistance in Helicobacter pylori strains isolated from patients with gastroduodenal disorders

2019 ◽  
Vol Volume 12 ◽  
pp. 535-543 ◽  
Author(s):  
Seyed Jalal Hashemi ◽  
Ahmad Farajzadeh Sheikh ◽  
Hamed Goodarzi ◽  
Mohammad Jaafar Yadyad ◽  
Seyed Saeid Seyedian ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Genetic Basis ◽  
Clarithromycin Resistance ◽  
Gastroduodenal Disorders

Helicobacter pylori: clarithromycin resistance and eradication rates in Szeged, Hungary – a pilot study

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
I Kovács ◽  
A Tiszai ◽  
Z Kiss ◽  
F Sükösd ◽  
I Nagy ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Pilot Study ◽  
Clarithromycin Resistance

scholarly journals Different dose of new generation proton pump inhibitors for the treatment of Helicobacter pylori infection: A meta-analysis

2021 ◽  
Vol 35 ◽  
pp. 205873842110303
Author(s):  
Wenwen Gao ◽  
Xiang Zhang ◽  
Yanhui Yin ◽  
Shuwen Yu ◽  
Lu Wang
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Eradication Rate ◽  
Standard Dose ◽  
Statistical Significance ◽  
High Dose ◽  
Clarithromycin Resistance ◽  
H Pylori ◽  
New Generation

The evidence on whether high-dose new generation proton pump inhibitors (PPIs) including rabeprazole and esomeprazole achieve a higher eradication rate of Helicobacter pylori has not been assessed. The primary comparison was eradication and adverse events (AEs) rate of standard (esomeprazole 20 mg bid, rabeprazole 10 mg bid) versus high-dose (esomeprazole 40 mg bid, rabeprazole 20 mg bid) PPIs. Sub-analyses were performed to evaluate the eradication rate between Asians and Caucasians, clarithromycin-resistance (CAM-R) strains, and clarithromycin-sensitivity (CAM-S) strains of different dose PPIs. We conducted a literature search for randomized controlled trials comparing high-with standard-dose esomeprazole and rabeprazole for H. pylori eradication and AEs. A total of 12 trials with 2237 patients were included. The eradication rate of high-dose PPIs was not significantly superior to standard-dose PPIs regimens: 85.3% versus 84.2%, OR 1.09 (0.86–1.37), P = 0.47. The high dose induced more AEs than those of the standard dose, but didn’t reach statistical significance (OR 1.25, 95% CI: 0.99–1.56, P = 0.06). Subgroup analysis showed that the difference in eradication rate of PPIs between high- and standard-dose groups were not statistically significant both in Asians (OR 0.99, 95% CI 0.75–1.32, P = 0.97) and Caucasians (OR 1.27, 95% CI 0.84–1.92, P = 0.26). Furthermore, there were similar eradication rates in CAM-S (OR 1.2; 95% CI 0.58–2.5; P = 0.63) and CAM-R strains (OR 1.08; 95% CI 0.45–2.56; P = 0.87) between the standard-and high-dose groups. High and standard dosages of new generation of the PPIs showed similar H. pylori eradication rates and AEs as well as between Asian versus Caucasian populations, with or without clarithromycin-resistance. However, further studies are needed to confirm.

Helicobacter pylori clarithromycin resistance detected by Etest and TaqMan real-time polymerase chain reaction: a comparative study

Apmis ◽  
2012 ◽  
Vol 120 (9) ◽  
pp. 712-717 ◽  
Author(s):  
Rosa Monno ◽  
Floriana Giorgio ◽  
Panella Carmine ◽  
Leonardo Soleo ◽  
Vittoria Cinquepalmi ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Helicobacter Pylori ◽  
Comparative Study ◽  
Real Time ◽  
Chain Reaction ◽  
Clarithromycin Resistance ◽  
Polymerase Chain

Clinical impact of Helicobacter pylori clarithromycin resistance on eradicating therapies in children: A cohort retrospective study

2008 ◽  
Vol 40 (10) ◽  
pp. A91-A92 ◽  
Author(s):  
R. Francavilla ◽  
E. Lionetti ◽  
A. Magistà ◽  
S. Castellaneta ◽  
A. De Canio ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Retrospective Study ◽  
Clinical Impact ◽  
Clarithromycin Resistance

scholarly journals Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing

2014 ◽  
Vol 69 (7) ◽  
pp. 1796-1803 ◽  
Author(s):  
Tran Thanh Binh ◽  
Seiji Shiota ◽  
Rumiko Suzuki ◽  
Miyuki Matsuda ◽  
Tran Thi Huyen Trang ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Novel Mutations ◽  
Clarithromycin Resistance ◽  
Generation Sequencing
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