scholarly journals Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence

2019 ◽  
Vol Volume 12 ◽  
pp. 185-210 ◽  
Author(s):  
Raju K Mandal ◽  
Munawwar Ali Khan ◽  
Arif Hussain ◽  
Sajad A. Dar ◽  
Sultan Aloufi ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Trial Sequence ◽  
Mbl2 Gene ◽  
Tuberculosis Susceptibility

scholarly journals Meta-Analysis on the Associations of TLR2 Gene Polymorphisms with Pulmonary Tuberculosis Susceptibility among Asian Populations

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e75090 ◽  
Author(s):  
Jia-Jia Wang ◽  
Xian Xia ◽  
Shai-Di Tang ◽  
Jie Wang ◽  
Xiao-Zhao Deng ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Tlr2 Gene ◽  
Asian Populations ◽  
Tuberculosis Susceptibility

scholarly journals Pharmacogenetic association between NAT2 gene polymorphisms and isoniazid induced hepatotoxicity: trial sequence meta-analysis as evidence

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Saif Khan ◽  
Raju K. Mandal ◽  
Abdulbaset Mohamed Elasbali ◽  
Sajad A. Dar ◽  
Arshad Jawed ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Term Treatment ◽  
Wild Type ◽  
Severe Problem ◽  
Trial Sequence ◽  
Increased Risk ◽  
Long Term Treatment ◽  
Nat2 Gene

Abstract Hepatotoxicity is a severe problem generally faced by tuberculosis (TB) patients. It is a well-known adverse reaction due to anti-TB drugs in TB patients undergoing long-term treatment. The studies published previously have explored the connection of N-acetyltransferase 2 (NAT2) gene polymorphisms with isoniazid-induced hepatotoxicity, but the results obtained were inconsistent and inconclusive. A comprehensive trial sequence meta-analysis was conducted employing 12 studies comprising 3613 controls and 933 confirmed TB cases using the databases namely, EMBASE, PubMed (Medline) and Google Scholar till December 2017. A significant association was observed with individuals carrying variant allele at position 481C>T (T vs. C: P = 0.001; OR = 1.278, 95% CI = 1.1100–1.484), at position 590G>A (A vs. G: P = 0.002; OR = 1.421, 95% CI = 1.137–1.776) and at position 857G>A (A vs. G: P = 0.0022; OR = 1.411, 95% CI = 1.052–1.894) to higher risk of hepatotoxicity vis-à-vis wild-type allele. Likewise, the other genetic models of NAT2 gene polymorphisms have also shown increased risk of hepatotoxicity. No evidence of publication bias was observed. These results suggest that genetic variants of NAT2 gene have significant role in isoniazid induced hepatotoxicity. Thus, NAT2 genotyping has the potential to improve the understanding of the drug–enzyme metabolic capacity and help in early predisposition of isoniazid-induced hepatotoxicity.

scholarly journals A Meta-Analysis of P2X7 Gene-762T/C Polymorphism and Pulmonary Tuberculosis Susceptibility

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96359 ◽  
Author(s):  
Lingling Yi ◽  
Dan Cheng ◽  
Huimin Shi ◽  
Xiaorong Huo ◽  
Kan Zhang ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Tuberculosis Susceptibility

scholarly journals NOD2 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 10 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Chong Wang ◽  
Zhong-Liang Chen ◽  
Zhi-Fen Pan ◽  
Li-Liang Wei ◽  
Dan-Dan Xu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Tuberculosis Susceptibility
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