scholarly journals Risk factors and prognosis of complicated urinary tract infections caused by Pseudomonas aeruginosa in hospitalized patients: a retrospective multicenter cohort study

2018 ◽  
Vol Volume 11 ◽  
pp. 2571-2581 ◽  
Author(s):  
A Gomila ◽  
J Carratalà ◽  
N Eliakim-Raz ◽  
E Shaw ◽  
I Wiegand ◽  
...  
2013 ◽  
Vol 45 (10) ◽  
pp. 773-779 ◽  
Author(s):  
Yoshio Haga ◽  
Nobutomo Miyanari ◽  
Tadateru Takahashi ◽  
Shoichiro Koike ◽  
Ryozo Kobayashi ◽  
...  

Author(s):  
Ana Carolina da C. Campos ◽  
Nathália Andrade ◽  
Julio C. D. Correal ◽  
Carla C. Santos ◽  
Marines du Teil Espina ◽  
...  

Background: Extraintestinal pathogenic Escherichia coli (ExPEC) is the most common cause of urinary tract infections (UTIs). They are often multidrug-resistant (MDR), making them challenging to treat. Additionally, virulence mechanisms as biofilm formation are associated with persistent UTIs. Aims: To reveal a possible association between patients’ risk factors and UTIs caused by MDR or biofilm-forming ExPECs and characterize ExPECs causing asymptomatic bacteriuria, community- (CA), or hospital-acquired (HA) UTIs in hospitalized patients in Brazil. Methods: Bacterial DNA was extracted from the urine of 63 hospitalized patients and sequenced using short-read sequencing. Antibiotic susceptibility was evaluated using VITEK-2, and the biofilm-forming, adhesion, and invasion abilities were quantitatively assessed. Results: Antibiotic resistance rates were high, and the majority of UTIs were complicated CA-UTIs. Most MDR- and ESBL-producing E. coli isolates belonged to high-risk lineages and were associated with UTIs in patients with comorbidities and over 60 years of age. The mortality rate of patients infected with MDR-isolates was higher than of those infected with non-MDR isolates. Most isolates were biofilm-forming, but no association with patients’ risk factors was found. Conclusions: Complicated UTIs caused by MDR- and biofilm-forming bacteria are frequently found in hospitalized patients in Brazil suffering from a UTI and are associated with high-risk lineages.


PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0178178 ◽  
Author(s):  
Jose Luis Lamas Ferreiro ◽  
Judith Álvarez Otero ◽  
Lucía González González ◽  
Luis Novoa Lamazares ◽  
Alexandra Arca Blanco ◽  
...  

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