scholarly journals Clinical evaluation of the role of ceftaroline in the management of community acquired bacterial pneumonia

2012 ◽  
pp. 43 ◽  
Author(s):  
Marcos Restrepo ◽  
Diego J. Maselli ◽  
Juan F. Fernandez ◽  
Kelly Echevarria ◽  
Anoop Nambiar ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Bacterial Pneumonia

The Role of Myocardial Perfusion Imaging in the Clinical Evaluation of Coronary Artery Disease in Women

2006 ◽  
Vol 3 (2) ◽  
pp. 68-72
Author(s):  
Jennifer Mieres ◽  
Leslee J Shaw ◽  
Robert C Hendel ◽  
D Douglas Miller ◽  
Robert Bonow ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Clinical Evaluation ◽  
Perfusion Imaging ◽  
Artery Disease

scholarly journals Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study

2021 ◽  
Author(s):  
Amal A Gharamti ◽  
Fei Mei ◽  
Katherine C Jankousky ◽  
Jin Huang ◽  
Peter Hyson ◽  
...  
Keyword(s):  
Bacterial Pneumonia ◽  
Operating Characteristic ◽  
Case Control Study ◽  
Receiver Operating Characteristic Analysis ◽  
Similar Proportion ◽  
Characteristic Analysis ◽  
Multivariable Analyses ◽  
Prevalence Of Diabetes Mellitus ◽  
Control Study

Abstract Background There is an urgent need for accurate, rapid, inexpensive biomarkers that can differentiate COVID-19 from bacterial pneumonia. We assess the role of the ferritin-to-procalcitonin (F/P) ratio to classify pneumonia cases into those due to COVID-19 or due to bacterial pathogens. Methods This multicenter case-control study compared patients with either COVID-19 and bacterial pneumonia, admitted between March 1 and May 31, 2020. Patients with COVID-19 and bacterial pneumonia co-infection were excluded. The F/P in patients with COVID-19 or with bacterial pneumonia were compared. Receiver operating characteristic analysis determined the sensitivity and specificity of various cut-off F/P values for COVID-19 versus bacterial pneumonia. Results A total of 242 COVID-19 pneumonia cases and 34 bacterial pneumonia controls were included. Patients with COVID-19 pneumonia had a lower mean age (57.11 vs 64.4 years, p=0.02) and a higher BMI (30.74 vs 27.15 kg/m 2, p=0.02) compared to patients with bacterial pneumonia. Cases and controls had a similar proportion of women (47% vs 53%, p=0.5) and COVID-19 patients had a higher prevalence of diabetes mellitus (32.6% vs 12%, p=0.01). The median F/P was significantly higher in patients with COVID-19 (4037.5) compared to the F/P in bacterial pneumonia (802, p<0.001). An F/P ≥ 877 used to diagnose COVID-19 resulted in a sensitivity of 85% and a specificity of 56%, with a positive predictive value of 93.2%, and a likelihood ratio of 1.92. In multivariable analyses, an F/P ≥ 877 was associated with greater odds of identifying a COVID-19 case (OR: 11.27, CI: 4-31.2, p<0.001). Conclusion An F/P ≥ 877 increases the likelihood of COVID-19 pneumonia compared to bacterial pneumonia.

scholarly journals TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia

2012 ◽  
Vol 302 (5) ◽  
pp. L447-L454 ◽  
Author(s):  
Louis R. Standiford ◽  
Theodore J. Standiford ◽  
Michael J. Newstead ◽  
Xianying Zeng ◽  
Megan N. Ballinger ◽  
...  
Keyword(s):  
Lung Injury ◽  
Bacterial Pneumonia ◽  
Lavage Fluid ◽  
Alveolar Epithelial Cells ◽  
Intratracheal Administration ◽  
Bacterial Colony ◽  
Gram Negative ◽  
Gm Csf

Toll-like receptors (TLRs) are required for protective host defense against bacterial pathogens. However, the role of TLRs in regulating lung injury during Gram-negative bacterial pneumonia has not been thoroughly investigated. In this study, experiments were performed to evaluate the role of TLR4 in pulmonary responses against Klebsiella pneumoniae (Kp). Compared with wild-type (WT) (Balb/c) mice, mice with defective TLR4 signaling (TLR4lps-d mice) had substantially higher lung bacterial colony-forming units after intratracheal challenge with Kp, which was associated with considerably greater lung permeability and lung cell death. Reduced expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA and protein was noted in lungs and bronchoalveolar lavage fluid of TLR4 mutant mice postintratracheal Kp compared with WT mice, and primary alveolar epithelial cells (AEC) harvested from TLR4lps-d mice produced significantly less GM-CSF in vitro in response to heat-killed Kp compared with WT AEC. TLR4lps-d AEC underwent significantly more apoptosis in response to heat-killed Kp in vitro, and treatment with GM-CSF protected these cells from apoptosis in response to Kp. Finally, intratracheal administration of GM-CSF in TLR4lps-d mice significantly decreased albumin leak, lung cell apoptosis, and bacteremia in Kp-infected mice. Based on these observations, we conclude that TLR4 plays a protective role on lung epithelium during Gram-negative bacterial pneumonia, an effect that is partially mediated by GM-CSF.

scholarly journals The Role of Self- and Informant-Reports on Symptoms and Impairments in the Clinical Evaluation of Adult ADHD

2021 ◽  
Vol 13 (8) ◽  
pp. 4564
Author(s):  
Nana Guo ◽  
Anselm B. M. Fuermaier ◽  
Janneke Koerts ◽  
Bernhard W. Mueller ◽  
Christian Mette ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Test Performance ◽  
Adult Adhd ◽  
Comparison Group ◽  
Neuropsychological Test ◽  
Neuropsychological Testing ◽  
Adhd Group ◽  
Adhd Symptoms ◽  
Clinical Comparison

Little is known about which clinical features may aid the differentiation between attention deficit hyperactivity disorder (ADHD) and other clinical conditions. This study seeks to determine the role of self- and informant reports on symptoms and impairments in the clinical evaluation of adult ADHD and explore their association with objective neuropsychological test performance by examining data of 169 outpatients referred for a diagnostic evaluation of adult ADHD. Participants were assigned either to an ADHD group (ADHD, n = 73) or one of two clinical comparison groups, depending on whether they show indications (Clinical Comparison Group, CCG, n = 53) or no indications (Clinical Comparison Group—Not Diagnosed, CCG-ND, n = 43) of psychiatric disorders other than ADHD. All participants and their informants completed a set of questionnaires. Compared to the CCG-ND, the ADHD group obtained significantly higher scores on ADHD symptoms, impulsivity, cognitive deficits, and anxiety. Compared to the CCG, the ADHD group scored significantly higher on ADHD symptoms but lower on depression. Further regression analyses revealed that self- and informant reports failed to predict neuropsychological test performance. Self- and informant reported information may be distinct features and do not correspond to results of objective neuropsychological testing.

EFFECTS OF ASPHYXIATION OF THE FETUS AND THE NEWBORN INFANT

PEDIATRICS ◽  
1960 ◽  
Vol 26 (4) ◽  
pp. 565-569
Author(s):  
William F. Windle
Keyword(s):  
Cerebral Palsy ◽  
Mental Retardation ◽  
Newborn Infant ◽  
Clinical Evaluation ◽  
Neurological Disorders ◽  
Basic Information ◽  
Clinical Experiences ◽  
Asphyxia Neonatorum

There is pressing need of well controlled clinical evaluation of the role of adverse factors in the prenatal, natal and early postnatal periods in the etiology of neurological disorders. This is particularly true of asphyxia neonatorum. Many articles have been written on relationships between apnea, anoxia or asphyxia and manifestations of mental retardation, cerebral palsy, epilepsy and othe neurological, psychological and behavioral defects. The majority of the writers express opinions, but give no evidence that data were collected. Controls are commonly lacking. Often no attempt to measure the variables appears to have been made. A review1 of more than 500 reports, commentaries and testimonials of clinical experiences reveals deficiency in basic information of physiology of the fetus and newborn that is nothing short of appalling.

The Role of Myocardial Perfusion Imaging in the Clinical Evaluation of Coronary Artery Disease in Women

2006 ◽  
Vol 3 (1) ◽  
pp. 66-70
Author(s):  
Jennifer Mieres ◽  
Leslee J Shaw ◽  
Robert C Hendel ◽  
D Douglas Miller ◽  
Robert Bonow ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Clinical Evaluation ◽  
Perfusion Imaging ◽  
Artery Disease

The Role Of FDG PET/CT In The Clinical Evaluation Of Chronic Sarcoidosis

2012 ◽  
Author(s):  
Jelica L. Videnovic-Ivanov ◽  
Dragana Sobic-Saranovic ◽  
Irena Grozdic ◽  
Snezana Filipovic-Stepic ◽  
Violeta Vucinic ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Fdg Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Zhen Qin ◽  
Yuan Yang ◽  
Hongren Wang ◽  
Jun Luo ◽  
Xiaojun Huang ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Influenza A Virus ◽  
Bacterial Pneumonia ◽  
Influenza A ◽  
Bacterial Infections ◽  
Research Progress ◽  
The Past ◽  
Recent Research Progress ◽  
Increased Susceptibility

The risk of influenza A virus (IAV) is more likely caused by secondary bacterial infections. During the past decades, a great amount of studies have been conducted on increased morbidity from secondary bacterial infections following influenza and provide an increasing number of explanations for the mechanisms underlying the infections. In this paper, we first review the recent research progress that IAV infection increased susceptibility to bacterial infection. We then propose an assumption that autophagy and apoptosis manipulation are beneficial to antagonize post-IAV bacterial infection and discuss the clinical significance.

scholarly journals Role of the Patient’s History of Vestibular Symptoms in the Clinical Evaluation of the Bedside Head-Impulse Test

2017 ◽  
Vol 8 ◽  
Author(s):  
Christoph Helmchen ◽  
Julia Knauss ◽  
Peter Trillenberg ◽  
Anita Frendl ◽  
Andreas Sprenger
Keyword(s):  
Clinical Evaluation ◽  
Head Impulse Test ◽  
Head Impulse ◽  
History Of ◽  
Vestibular Symptoms ◽  
Patient’S History
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