scholarly journals Successful control of resistance in Pseudomonas aeruginosa using antibiotic stewardship and infection control programs at a Chinese university hospital: a 6-year prospective study

2018 ◽  
Vol Volume 11 ◽  
pp. 637-646 ◽  
Author(s):  
Lei Liu ◽  
Bin Liu ◽  
Yu Li ◽  
Wei Zhang
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Infection Control ◽  
Prospective Study ◽  
Antibiotic Stewardship ◽  
University Hospital ◽  
Control Programs ◽  
Chinese University ◽  
Successful Control

scholarly journals A prospective study of the use of antibiotics in the Emergency Department of a Chinese University Hospital

2017 ◽  
Vol 25 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Linan Zeng ◽  
Die Hu ◽  
Imti Choonara ◽  
Dezhi Mu ◽  
Lingli Zhang ◽  
...  
Keyword(s):  
Emergency Department ◽  
Prospective Study ◽  
University Hospital ◽  
Chinese University ◽  
A Prospective Study

scholarly journals Implementation of Antibiotic Stewardship in a University Hospital Setting

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 93
Author(s):  
Milan Kolar ◽  
Miroslava Htoutou Sedlakova ◽  
Karel Urbanek ◽  
Patrik Mlynarcik ◽  
Magdalena Roderova ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Antibiotic Stewardship ◽  
Bacterial Infections ◽  
Hospital Setting ◽  
University Hospital ◽  
Beta Lactam ◽  
Stewardship Program ◽  
Clonal Spread

The article describes activities of an antibiotic center at a university hospital in the Czech Republic and presents the results of antibiotic stewardship program implementation over a period of 10 years. It provides data on the development of resistance of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus to selected antibiotic agents as well as consumption data for various antibiotic classes. The genetic basis of resistance to beta-lactam antibiotics and its clonal spread were also assessed. The study showed significant correlations between aminoglycoside consumption and resistance of Escherichia coli and Klebsiella pneumoniae to gentamicin (r = 0.712, r = 0.869), fluoroquinolone consumption and resistance of Klebsiella pneumoniae to ciprofloxacin (r = 0.896), aminoglycoside consumption and resistance of Pseudomonas aeruginosa to amikacin (r = 0.716), as well as carbapenem consumption and resistance of Pseudomonas aeruginosa to meropenem (r = 0.855). Genotyping of ESBL- positive isolates of Klebsiella pneumoniae and Escherichia coli showed a predominance of CTX-M-type; in AmpC-positive strains, DHA, EBC and CIT enzymes prevailed. Of 19 meropenem-resistant strains of Klebsiella pneumoniae, two were identified as NDM-positive. Clonal spread of these strains was not detected. The results suggest that comprehensive antibiotic stewardship implementation in a healthcare facility may help to maintain the effectiveness of antibiotics against bacterial pathogens. Particularly beneficial is the work of clinical microbiologists who, among other things, approve administration of antibiotics to patients with bacterial infections and directly participate in their antibiotic therapy.

Effect of Educational Programs, Rigid Sharps Containers, and Universal Precautions on Reported Needlestick Injuries in Healthcare Workers

1991 ◽  
Vol 12 (4) ◽  
pp. 214-219 ◽  
Author(s):  
Calvin C. Linnemann ◽  
Constance Cannon ◽  
Martha DeRonde ◽  
Bruce Lanphear
Keyword(s):  
Infection Control ◽  
General Hospital ◽  
Educational Program ◽  
Healthcare Workers ◽  
University Hospital ◽  
Needlestick Injuries ◽  
Universal Precautions ◽  
Control Programs ◽  
University Of Cincinnati ◽  
The University

AbstractObjective:To evaluate the effect of infection control programs on reported needlestick injuries in a general hospital.Design:Surveillance of all reported needlestick injuries at the University of Cincinnati Hospital was maintained by the infection control department for five years, from 1985 through 1989. Data on individual workers were collected, tabulated on a monthly basis, and reviewed continually to monitor trends in injuries. During this time, the effects of each of three new infection control programs on reported injuries were evaluated sequentially.Setting:A 700-bed general hospital that serves as the main teaching hospital of the University of cincinnati.Participants:All employees of University Hospital who reported to personnel health for management of needlestick injuries.Interventions:In 1986, an educational program to prevent injuries was initiated and continued throughout the surveillance period. In 1987, rigid sharps disposal containers were placed in all hospital rooms. In 1988, universal precautions were introduced with an intensive inservice.Results:Surveillance identified 1,602 needlestick injuries (320/year) or 104/1 ,000/ year. After the educational program began, reported injuries increased rather than decreased, and this was attributed to increased reporting. Subsequently, after installation of the new disposal containers, reported injuries returned to the levels seen prior to the educational program, but recapping injuries showed a significant decrease from 63/year to 30, or 20/1,000/year to 10. This decrease was observed in nurses but not in other healthcare workers. After universal precautions were instituted, total injuries increased slightly, but recapping injuries remained at 50% of the levels reported prior to the use of rigid sharps disposal containers.Conclusions: The three infection control programs failed to produce a major reduction in reported needlestick injuries, except for a decrease in recapping injuries associated with the placement of rigid sharps disposal containers in all patient rooms. These observations indicate that new approaches are needed to reduce needlestick injuries.

The role of blood inflammatory markers in the diagnosis of appendicitis in children: a prospective study from a University Hospital in Greece

2020 ◽  
Vol 178 (11) ◽  
Author(s):  
George Sakellaris ◽  
Dimitra Dimopoulou ◽  
Maria Niniraki ◽  
Anastasia Dimopoulou ◽  
Athanasios Alegakis ◽  
...  
Keyword(s):  
Prospective Study ◽  
Inflammatory Markers ◽  
University Hospital ◽  
A Prospective Study

Strategies for Infection Control and Prevalence of Anti-SARS-CoV-2 IgG Antibodies in 4,554 Employees of a University Hospital in Munich, Germany

2020 ◽  
Author(s):  
Johanna Erber ◽  
Verena Kappler ◽  
Bernhard Haller ◽  
Hrvoje Mijočević ◽  
Ana Galhoz ◽  
...  
Keyword(s):  
Infection Control ◽  
University Hospital ◽  
Igg Antibodies

Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas aeruginosa in Keratitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Debarati Paul ◽  
Suman Saha ◽  
Neelam Singh ◽  
Jayansgu Sengupta ◽  
Santi M. Mandal
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Candida Albicans ◽  
Histopathological Examination ◽  
Specific Interaction ◽  
Major Threat ◽  
Effective Combination ◽  
Male Farmer ◽  
Successful Control ◽  
The Right ◽  
Corneal Button

Introduction: Nowadays, co-infection by interspecific organisms is major threat in infection control. To identify the effective combination of drugs to control the keratitis caused by Candida albicans with Pseudomonas aeruginosa are attributed in this study. Materilas and Methods: The patient of a 47 years old male farmer with infection in the right eye which showed redness and watering was treated with fortified cefazolin and fortified tobramycin before referral. No pigmentation or vascularisation was noted. The excised corneal button was also subjected to microbiological and histopathological examination. Results: A rare case of keratitis caused by co-infection of Candida albicans with Pseudomonas aeruginosa was identified. Results confirmed the inter-specific interaction of the two microorganisms. Conclusion: Cases of co-infection by Candida and Pseudomonas are not abundantly reported and difficult to treat. In this case, treatment involved Amphotercin-B and ciprofloxacin, effectively eradicated the infection. This therapy may be successfully implied for such cases of co-infection in future.

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