scholarly journals Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant Candida tropicalis and Candida glabrata isolates with delineation of their resistance mechanisms

2018 ◽  
Vol Volume 11 ◽  
pp. 155-161 ◽  
Author(s):  
Meng Xiao ◽  
Xin Fan ◽  
Xin Hou ◽  
Sharon Chen ◽  
He Wang ◽  
...  
Keyword(s):  
Candida Tropicalis ◽  
Invasive Candidiasis ◽  
Candida Glabrata ◽  
Clinical Characteristics ◽  
Resistance Mechanisms

Clinical characteristics of Candida tropicalis fungaemia with reduced triazole susceptibility in Taiwan: a multicentre study

2019 ◽  
Vol 53 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Wei-Lun Liu ◽  
Yu-Tsung Huang ◽  
Min-Han Hsieh ◽  
Ing-Moi Hii ◽  
Yu-Lin Lee ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Candida Tropicalis ◽  
Clinical Characteristics

scholarly journals Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection

2008 ◽  
Vol 52 (10) ◽  
pp. 3783-3785 ◽  
Author(s):  
George R. Thompson ◽  
Nathan P. Wiederhold ◽  
Ana C. Vallor ◽  
Nyria C. Villareal ◽  
James S. Lewis ◽  
...  
Keyword(s):  
Invasive Candidiasis ◽  
Hot Spots ◽  
Candida Glabrata ◽  
Glucan Synthase ◽  
Prolonged Therapy ◽  
Echinocandin Resistance

ABSTRACT We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

scholarly journals Molecular mechanisms of azole resistance in Candida tropicalis isolates causing invasive candidiasis in China

2019 ◽  
Vol 25 (7) ◽  
pp. 885-891 ◽  
Author(s):  
X. Fan ◽  
M. Xiao ◽  
D. Zhang ◽  
J.-J. Huang ◽  
H. Wang ◽  
...  
Keyword(s):  
Candida Tropicalis ◽  
Invasive Candidiasis ◽  
Molecular Mechanisms ◽  
Azole Resistance

FORMACIÓN DE BIOPELÍCULAS Y SENSIBILIDAD A ANTIFÚNGICOS DE Candida albicans, Candida tropicalis Y Candida glabrata

2021 ◽  
pp. 93-105
Author(s):  
Alejandra Paula Espinosa Texis ◽  
Débora Vázquez Domínguez ◽  
David Iván Loaiza Toscuento ◽  
Teresita Spezzia Mazzocco
Keyword(s):  
Candida Albicans ◽  
Candida Tropicalis ◽  
Candida Glabrata

scholarly journals Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin

2019 ◽  
Vol 20 (9) ◽  
pp. 2345 ◽  
Author(s):  
Mónica Galocha ◽  
Pedro Pais ◽  
Mafalda Cavalheiro ◽  
Diana Pereira ◽  
Romeu Viana ◽  
...  
Keyword(s):  
Stress Resistance ◽  
Biofilm Formation ◽  
Candida Glabrata ◽  
Resistance Mechanisms ◽  
Dependent Manner ◽  
Fungal Virulence ◽  
Tissue Invasion ◽  
Etiologic Agents ◽  
Two Sides ◽  
Secreted Enzymes

Candida albicans and Candida glabrata are the two most prevalent etiologic agents of candidiasis worldwide. Although both are recognized as pathogenic, their choice of virulence traits is highly divergent. Indeed, it appears that these different approaches to fungal virulence may be equally successful in causing human candidiasis. In this review, the virulence mechanisms employed by C. albicans and C. glabrata are analyzed, with emphasis on the differences between the two systems. Pathogenesis features considered in this paper include dimorphic growth, secreted enzymes and signaling molecules, and stress resistance mechanisms. The consequences of these traits in tissue invasion, biofilm formation, immune system evasion, and macrophage escape, in a species dependent manner, are discussed. This review highlights the observation that C. albicans and C. glabrata follow different paths leading to a similar outcome. It also highlights the lack of knowledge on some of the specific mechanisms underlying C. glabrata pathogenesis, which deserve future scrutiny.

scholarly journals Probiotic Yeasts Inhibit Virulence of Non-albicans Candida Species

mBio ◽  
2019 ◽  
Vol 10 (5) ◽  
Author(s):  
Lohith Kunyeit ◽  
Nawneet K. Kurrey ◽  
K. A. Anu-Appaiah ◽  
Reeta P. Rao
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Tropicalis ◽  
Biofilm Formation ◽  
Candida Glabrata ◽  
Candida Parapsilosis ◽  
Candida Krusei ◽  
Probiotic Properties ◽  
Candida Auris ◽  
Content Type ◽  
Alternative Approach

ABSTRACT Systemic infections of Candida species pose a significant threat to public health. Toxicity associated with current therapies and emergence of resistant strains present major therapeutic challenges. Here, we report exploitation of the probiotic properties of two novel, food-derived yeasts, Saccharomyces cerevisiae (strain KTP) and Issatchenkia occidentalis (strain ApC), as an alternative approach to combat widespread opportunistic fungal infections. Both yeasts inhibit virulence traits such as adhesion, filamentation, and biofilm formation of several non-albicans Candida species, including Candida tropicalis, Candida krusei, Candida glabrata, and Candida parapsilosis as well as the recently identified multidrug-resistant species Candida auris. They inhibit adhesion to abiotic surfaces as well as cultured colon epithelial cells. Furthermore, probiotic treatment blocks the formation of biofilms of individual non-albicans Candida strains as well as mixed-culture biofilms of each non-albicans Candida strain in combination with Candida albicans. The probiotic yeasts attenuated non-albicans Candida infections in a live animal. In vivo studies using Caenorhabditis elegans suggest that exposure to probiotic yeasts protects nematodes from infection with non-albicans Candida strains compared to worms that were not exposed to the probiotic yeasts. Furthermore, application of probiotic yeasts postinfection with non-albicans Candida alleviated pathogenic colonization of the nematode gut. The probiotic properties of these novel yeasts are better than or comparable to those of the commercially available probiotic yeast Saccharomyces boulardii, which was used as a reference strain throughout this study. These results indicate that yeasts derived from food sources could serve as an effective alternative to antifungal therapy against emerging pathogenic Candida species. IMPORTANCE Non-albicans Candida-associated infections have emerged as a major risk factor in the hospitalized and immunecompromised patients. Besides, antifungal-associated complications occur more frequently with these non-albicans Candida species than with C. albicans. Therefore, as an alternative approach to combat these widespread non-albicans Candida-associated infections, here we showed the probiotic effect of two yeasts, Saccharomyces cerevisiae (strain KTP) and Issatchenkia occidentalis (ApC), in preventing adhesion and biofilm formation of five non-albicans Candida strains, Candida tropicalis, Candida krusei, Candida glabrata, Candida parapsilosis, and Candida auris. The result would influence the current trend of the conversion of conventional antimicrobial therapy into beneficial probiotic microbe-associated antimicrobial treatment.

The yeast, the antifungal, and the wardrobe: a journey into antifungal resistance mechanisms of Candida tropicalis

2020 ◽  
Vol 66 (6) ◽  
pp. 377-388
Author(s):  
Jonathas Sales de Oliveira ◽  
Vandbergue Santos Pereira ◽  
Débora de Souza Collares Maia Castelo-Branco ◽  
Rossana de Aguiar Cordeiro ◽  
José Júlio Costa Sidrim ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Intensive Care ◽  
Candida Tropicalis ◽  
Clinical Management ◽  
Candida Species ◽  
Genetic Basis ◽  
Antifungal Susceptibility ◽  
Resistance Mechanisms ◽  
Antifungal Resistance ◽  
Resistant Strains

Candida tropicalis is a prominent non-Candida albicans Candida species involved in cases of candidemia, mainly causing infections in patients in intensive care units and (or) those presenting neutropenia. In recent years, several studies have reported an increase in the recovery rates of azole-resistant C. tropicalis isolates. Understanding C. tropicalis resistance is of great importance, since resistant strains are implicated in persistent or recurrent and breakthrough infections. In this review, we address the main mechanisms underlying C. tropicalis resistance to the major antifungal classes used to treat candidiasis. The main genetic basis involved in C. tropicalis antifungal resistance is discussed. A better understanding of the epidemiology of resistant strains and the mechanisms involved in C. tropicalis resistance can help improve diagnosis and assessment of the antifungal susceptibility of this Candida species to improve clinical management.

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