scholarly journals A Potential Participant in Type 2 Diabetes Bone Fragility: TIMP-1 at Sites of Osteocyte Lacunar-Canalicular System

2021 ◽  
Vol Volume 14 ◽  
pp. 4903-4909
Author(s):  
Qilin Pei ◽  
Jun Li ◽  
Pengfei Zhou ◽  
Jun Zhang ◽  
Peng Huang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bone Fragility ◽  
Potential Participant ◽  
Osteocyte Lacunar

1983-P: WNT Pathway and Bone Fragility in Postmenopausal Women with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1983-P
Author(s):  
ALESSANDRA PICCOLI ◽  
FRANCESCA CANNATA ◽  
FABRIZIO RUSSO ◽  
VALENTINA L. GRETO ◽  
CAMILLA ISGRÒ ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Postmenopausal Women ◽  
Wnt Pathway ◽  
Bone Fragility

Type 2 diabetes and bone fragility- An under-recognized association

2021 ◽  
Vol 15 (3) ◽  
pp. 927-935
Author(s):  
Khalid J. Farooqui ◽  
Ambrish Mithal ◽  
Ann Kwee Kerwen ◽  
Manju Chandran
Keyword(s):  
Type 2 Diabetes ◽  
Bone Fragility

CD4+ T-cell activation of bone marrow causes bone fragility and insulin resistance in type 2 diabetes

Bone ◽  
2021 ◽  
pp. 116292
Author(s):  
S.E. Cifuentes-Mendiola ◽  
D.L. Solis-Suarez ◽  
A. Martínez-Dávalos ◽  
M. Godínez-Victoria ◽  
A.L. García-Hernández
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Bone Marrow ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Bone Fragility ◽  
Cd4 T Cell

scholarly journals Serum markers of bone fragility in type-2 diabetes mellitus

2019 ◽  
pp. 78-85
Author(s):  
Rucsandra Miulescu ◽  
Loreta Guja ◽  
Lavinia Ochiana ◽  
Anca Ungurianu ◽  
Oana Șeremet ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Fragility ◽  
Serum Markers

scholarly journals Fragility fractures and bone remodeling in type 2 diabetes mellitus

2017 ◽  
Vol 14 (3) ◽  
pp. 11-18 ◽  
Author(s):  
Tatiana O. Yalochkina ◽  
Zhanna E. Belaya
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Bone Fragility ◽  
Mineral Density ◽  
Severe Diabetes ◽  
Increased Risk

Fracture risk is significantly increased in both type 1 and type 2 diabetes and individuals with diabetes experience worse fracture outcomes compared to normoglycemic individuals. Patients with T1DM have decreased bone mineral density (BMD), whereas patients with T2DM demonstrate increased BMD compared to healthy control. The latest studies show increased incidence of low-traumatic fractures in patients with T2DM instead of high bone mineral density (BMD). The risk of osteoporotic fractures in patients with T2DM can be explained by disease complications and increased risk of falls and consequent trauma. However, the most important cause of bone fragility in T2DM is the deterioration in bone microarchitecture, the mechanism of which is not completely understood. High BMD in patients with T2DM does not allow us to use dual-energy X-ray-absorptiometry as a gold standard test for diagnosticsof osteoporosis. Consequently,new risk factors and diagnostic algorithm as well as treatment strategy should be developed for patients with T2DM. In addition to this, some researchers considered that the group of T2DM is geterogenous and physicians might face patients with osteoporosis and mild diabetes that add very little to bone fragility; patients with osteoporosis and moderate or severe diabetes which also affects bone tissue diabetoosteoporosis; and patients without osteoporosis but severe diabetes which cause bone tissue deterioration with the development of diabetic bone disease. New diagnostic tools and algorithm and new experimental research are needed for better understanding bone deterioration in patients with T2DM. This review summarizes our current knowledge on fracture rate, risk factors for fractures and causes of bone deterioration in subjects with T2DM.

Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes

2021 ◽  
Author(s):  
Praveer Sihota ◽  
Ram Naresh Yadav ◽  
Ruban Dhaliwal ◽  
Jagadeesh Chandra Bose ◽  
Vandana Dhiman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Trabecular Bone ◽  
Bone Tissue ◽  
Energy Absorption ◽  
Bone Quality ◽  
Fragility Fracture ◽  
Bone Fragility ◽  
Diabetic Group ◽  
Trabecular Bone Quality

Abstract Context Increased bone fragility and reduced energy absorption to fracture associated with type 2 diabetes (T2D) cannot be explained by bone mineral density alone. This study, for the first time, reports on alterations in bone tissue’s material properties obtained from individuals with diabetes and known fragility fracture status. Objective To investigate the role of T2D in altering biomechanical, microstructural, and compositional properties of bone in individuals with fragility fracture. Methods Femoral head bone tissue specimens were collected from patients who underwent replacement surgery for fragility hip fracture. Trabecular bone quality parameters were compared in samples of 2 groups, nondiabetic (n = 40) and diabetic (n = 30), with a mean duration of disease 7.5 ± 2.8 years. Results No significant difference was observed in aBMD between the groups. Bone volume fraction (BV/TV) was lower in the diabetic group due to fewer and thinner trabeculae. The apparent-level toughness and postyield energy were lower in those with diabetes. Tissue-level (nanoindentation) modulus and hardness were lower in this group. Compositional differences in the diabetic group included lower mineral:matrix, wider mineral crystals, and bone collagen modifications—higher total fluorescent advanced glycation end-products (fAGEs), higher nonenzymatic cross-link ratio (NE-xLR), and altered secondary structure (amide bands). There was a strong inverse correlation between NE-xLR and postyield strain, fAGEs and postyield energy, and fAGEs and toughness. Conclusion The current study is novel in examining bone tissue in T2D following first hip fragility fracture. Our findings provide evidence of hyperglycemia’s detrimental effects on trabecular bone quality at multiple scales leading to lower energy absorption and toughness indicative of increased propensity to bone fragility.

scholarly journals Osteoporosis, Fractures, and Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Peter Jackuliak ◽  
Juraj Payer
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mass ◽  
Bone Mineral ◽  
Bone Fractures ◽  
Trabecular Bone Score ◽  
Bone Fragility ◽  
Mineral Density ◽  
Increased Risk

It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice.

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