scholarly journals Association Between Early Markers of Renal Injury and Type 2 Diabetic Peripheral Neuropathy

2021 ◽  
Vol Volume 14 ◽  
pp. 4391-4397
Author(s):  
Zhi Yang ◽  
Xiaoyang Lou ◽  
Jie Zhang ◽  
Ronghui Nie ◽  
Jiang Liu ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Renal Injury ◽  
Diabetic Peripheral Neuropathy ◽  
Early Markers ◽  
Type 2 Diabetic

scholarly journals The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy

Medicine ◽  
2019 ◽  
Vol 98 (48) ◽  
pp. e18118 ◽  
Author(s):  
Binjie Zhang ◽  
Wenli Zhao ◽  
Jinli Tu ◽  
Xueying Wang ◽  
Yu Hao ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship ◽  
Type 2 Diabetic

Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients

2017 ◽  
Vol 54 (10) ◽  
pp. 925-931 ◽  
Author(s):  
Fan Wu ◽  
Yuanyuan Jing ◽  
Xiaojun Tang ◽  
Dai Li ◽  
Lilin Gong ◽  
...  
Keyword(s):  
Risk Factor ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Independent Risk Factor ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Decreased Microstructural Integrity of the Central Somatosensory Tracts in Diabetic Peripheral Neuropathy

2021 ◽  
Author(s):  
Fang Fang ◽  
Qian Luo ◽  
Ren-Bin Ge ◽  
Meng-Yu Lai ◽  
Yu-Jia Gong ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Diffusion Tensor ◽  
Central Nervous System Involvement ◽  
Diabetic Patients ◽  
Medial Lemniscus ◽  
Type 2 Diabetic Patients ◽  
Spinothalamic Tract ◽  
Type 2 Diabetic

Abstract Context Although diabetic peripheral neuropathy (DPN) is predominantly considered a disorder of the peripheral nerves, some evidence for central nervous system involvement has recently emerged. However, whether or to what extent the microstructure of central somatosensory tracts may be injured remains unknown. Objective This work aimed to detect the microstructure of central somatosensory tracts in type 2 diabetic patients and to correlate it with the severity of DPN. Methods A case-control study at a tertiary referral hospital took place with 57 individuals with type 2 diabetes (25 with DPN, 32 without DPN) and 33 nondiabetic controls. The fractional anisotropy (FA) values of 2 major somatosensory tracts (the spinothalamic tract and its thalamocortical [spino-thalamo-cortical, STC] pathway, the medial lemniscus and its thalamocortical [medial lemnisco-thalamo-cortical, MLTC] pathway) were assessed based on diffusion tensor tractography. Regression models were further applied to detect the association of FA values with the severity of DPN in diabetic patients. Results The mean FA values of left STC and left MLTC pathways were significantly lower in patients with DPN than those without DPN and controls. Moreover, FA values of left STC and left MLTC pathways were significantly associated with the severity of DPN (expressed as Toronto Clinical Scoring System values) in patients after adjusting for multiple confounders. Conclusion Our findings demonstrated the axonal degeneration of central somatosensory tracts in type 2 diabetic patients with DPN. The parallel disease progression of the intracranial and extracranial somatosensory system merits further attention to the central nerves in diabetic patients with DPN.

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